The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation (Q35650662)

9 August 2017

title

The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation (English)

1 reference

9 August 2017

Ly Vu

8

0 references

Xinyang Zhao

Xinyang Zhao

4

0 references

Fabiana Perna

Fabiana Perna

5

0 references

Jinsong Zhang

Jinsong Zhang

18

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Xiao-Jian Sun

Xiao-Jian Sun

3

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author name string

Lan Wang

1

1 reference

9 August 2017

Alexander Gural

2

1 reference

9 August 2017

Gang Huang

6

1 reference

9 August 2017

Megan A Hatlen

7

1 reference

9 August 2017

Fan Liu

9

1 reference

9 August 2017

Haiming Xu

10

1 reference

9 August 2017

Takashi Asai

11

1 reference

9 August 2017

Hao Xu

12

1 reference

9 August 2017

Tony Deblasio

13

1 reference

9 August 2017

Silvia Menendez

14

1 reference

9 August 2017

Francesca Voza

15

1 reference

9 August 2017

Yanwen Jiang

16

1 reference

9 August 2017

Philip A Cole

17

1 reference

9 August 2017

Ari Melnick

19

1 reference

9 August 2017

Robert G Roeder

20

1 reference

9 August 2017

Stephen D Nimer

21

1 reference

9 August 2017

language of work or name

English

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publication date

14 July 2011

1 reference

9 August 2017

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9 August 2017

volume

333

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9 August 2017

issue

6043

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9 August 2017

page(s)

765-769

1 reference

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor

9 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Balancing dormant and self-renewing hematopoietic stem cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Lysine acetylation targets protein complexes and co-regulates major cellular functions

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Post-translational modifications of Runx1 regulate its activity in the cell

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Structure of the AML1-ETO eTAFH domain-HEB peptide complex and its contribution to AML1-ETO activity.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Transforming activity of AML1-ETO is independent of CBFbeta and ETO interaction but requires formation of homo-oligomeric complexes

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

t(8;21)(q22;q22) Fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA-binding sequences to differentially regulate gene expression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Id1 restrains myeloid commitment, maintaining the self-renewal capacity of hematopoietic stem cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

E protein silencing by the leukemogenic AML1-ETO fusion protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Effects of the leukemia-associated AML1-ETO protein on hematopoietic stem and progenitor cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

The AML1/ETO fusion protein activates transcription of BCL-2

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Frequency analysis of human primitive haematopoietic stem cell subsets using a cobblestone area forming cell assay.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

A novel exon in AML1-ETO negatively influences the clonogenic potential of the t(8;21) in acute myeloid leukemia.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

The t(8;21) translocation converts AML1 into a constitutive transcriptional repressor

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3251012

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCIENCE.1201662

Synthesis and evaluation of a potent and selective cell-permeable p300 histone acetyltransferase inhibitor

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21764752

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCIENCE.1201662

1 reference

9 August 2017

0 references

1 reference

9 August 2017

1 reference