Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. (Q35501550)

8 August 2017

title

Antiangiogenic and antimetastatic activity of JAK inhibitor AZD1480. (English)

1 reference

8 August 2017

main subject

angiogenesis inhibitor

1 reference

Karen Reckamp

3

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author name string

Hong Xin

1

1 reference

8 August 2017

Andreas Herrmann

2

1 reference

8 August 2017

Wang Zhang

4

1 reference

8 August 2017

Sumanta Pal

5

1 reference

8 August 2017

Michael Hedvat

6

1 reference

8 August 2017

Chunyan Zhang

7

1 reference

8 August 2017

Wei Liang

8

1 reference

8 August 2017

Anna Scuto

9

1 reference

8 August 2017

Shaobu Weng

10

1 reference

8 August 2017

Deborah Morosini

11

1 reference

8 August 2017

Zhu A Cao

12

1 reference

8 August 2017

Michael Zinda

13

1 reference

8 August 2017

Robert Figlin

14

1 reference

8 August 2017

Dennis Huszar

15

1 reference

8 August 2017

Richard Jove

16

1 reference

8 August 2017

Hua Yu

17

1 reference

8 August 2017

language of work or name

English

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publication date

15 September 2011

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8 August 2017

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8 August 2017

volume

71

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8 August 2017

issue

21

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8 August 2017

page(s)

6601-6610

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The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival

8 August 2017

cites work

1 reference

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Discovery of 5-chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a novel inhibitor of the Jak/Stat pathway

12 July 2018

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STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors.

12 July 2018

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Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation.

12 July 2018

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Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten

12 July 2018

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The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors

12 July 2018

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STATs in cancer inflammation and immunity: a leading role for STAT3

12 July 2018

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The metastatic niche: adapting the foreign soil

12 July 2018

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Microenvironmental regulation of metastasis

12 July 2018

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Sunitinib inhibition of Stat3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells

12 July 2018

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Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment

12 July 2018

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IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer

12 July 2018

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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

12 July 2018

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Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice

12 July 2018

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The role of myeloid cells in the promotion of tumour angiogenesis

12 July 2018

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Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function

12 July 2018

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Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas

12 July 2018

1 reference

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Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment.

12 July 2018

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Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

12 July 2018

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

12 July 2018

1 reference

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Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity

12 July 2018

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Immunosuppressive networks in the tumour environment and their therapeutic relevance

12 July 2018

1 reference

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The STATs of cancer--new molecular targets come of age

12 July 2018

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Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells

12 July 2018

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Putting tumours in context

12 July 2018

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12 July 2018

1 reference

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Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

12 July 2018

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Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts.

12 July 2018

1 reference

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The tumour microenvironment as a target for chemoprevention.

26 September 2018

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Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis

26 September 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21920898

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Medicine. Tracing the steps of metastasis, cancer's menacing ballet

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21920898

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-11-1217

1 reference

8 August 2017

1 reference

8 August 2017

1 reference