A brief history of gene therapy (Q35222291)

7 August 2017

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title

A brief history of gene therapy (English)

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7 August 2017

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T. Friedmann

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1303270

11 September 2022

language of work or name

English

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publication date

1 October 1992

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7 August 2017

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7 August 2017

volume

2

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7 August 2017

issue

2

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7 August 2017

page(s)

93-98

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Human gene therapy comes of age.

7 August 2017

cites work

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STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES: INDUCTION OF TRANSFORMATION BY A DESOXYRIBONUCLEIC ACID FRACTION ISOLATED FROM PNEUMOCOCCUS TYPE III

21 January 2018

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The use of DNA for gene therapy--the need, experimental approach, and implications

21 January 2018

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Induction of arginase activity with the Shope papilloma virus in tissue culture cells from an argininemic patient

21 January 2018

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Molecular biology, nucleic acids, and the future of medicine

21 January 2018

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Amplification and characterization of a β-globin gene synthesized in vitro

21 January 2018

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A new technique for the assay of infectivity of human adenovirus 5 DNA

21 January 2018

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Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

21 January 2018

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Factors Governing the Expression of a Bacterial Gene in Mammalian Cells

21 January 2018

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Sounding boards. Gene therapy in human beings: when is it ethical to begin?

21 January 2018

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Mechanism of cell transformation by RNA tumor viruses

21 January 2018

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Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus

21 January 2018

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Adaptation of a Retrovirus as a Eucaryotic Vector Transmitting the Herpes Simplex Virus Thymidine Kinase Gene

21 January 2018

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Generation of helper-free amphotropic retroviruses that transduce a dominant-acting, methotrexate-resistant dihydrofolate reductase gene

21 January 2018

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Redesign of retrovirus packaging cell lines to avoid recombination leading to helper virus production

21 January 2018

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Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

21 January 2018

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In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

21 January 2018

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Human gene therapy: why draw a line?

21 January 2018

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Expression of human adenosine deaminase in mice transplanted with hemopoietic stem cells infected with amphotropic retroviruses

21 January 2018

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Defective and nondefective adenovirus vectors for expressing foreign genes in vitro and in vivo

21 January 2018

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The herpes simplex virus amplicon: A new eucaryotic defective-virus cloning-amplifying vector

21 January 2018

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A latent, nonpathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons

21 January 2018

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Interleukin 2 gene transfer into tumor cells abrogates tumorigenicity and induces protective immunity

21 January 2018

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Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 5 or 18

21 January 2018

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Grafting genetically modified cells to the brain: possibilities for the future

21 January 2018

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Transcriptional activation of cloned human β-globin genes by viral immediate-early gene products

21 January 2018

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Human dystrophin expression in mdx mice after intramuscular injection of DNA constructs

21 January 2018

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Prospects for Human Gene Therapy

21 January 2018

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7 January 2021

Progress toward human gene therapy

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7 January 2021

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7 January 2021

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7 January 2021

Genetics of human cess line. IV. DNA-mediated heritable transformation of a biochemical trait

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7 January 2021

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

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7 January 2021

Genetics of somatic mammalian cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells

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7 January 2021

Incorporation of Deoxyribonucleic Acid by Mammalian Cells in vitro

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7 January 2021

INCORPORATION OF DNA INTO A MOUSE TUMOR IN VIVO AND IN VITRO

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7 January 2021

DNA transformation studies with mammalian cells in culture

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7 January 2021

DNA mediated genetic transformation of a human cancerous cell line cultured in vitro

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7 January 2021

Fate of exogenous mouse DNA in chicken fibroblasts in vitro. Non-conservative preservation

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7 January 2021

The integrated state of viral DNA in SV40-transformed cells

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7 January 2021

Use of Viruses as Carriers of Added Genetic Information

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7 January 2021

In vitro reassembly of shell-like particles from disrupted polyoma virus

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7 January 2021

Gene Therapy for Human Genetic Disease?

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7 January 2021

On the arginase of the Shope papillomas

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7 January 2021

Prospects for genetic intervention in man

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7 January 2021

Gene therapy for human genetic disease?

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7 January 2021

Biochemical method for inserting new genetic information into DNA of Simian Virus 40: circular SV40 DNA molecules containing lambda phage genes and the galactose operon of Escherichia coli

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7 January 2021

The future for gene therapy--a reevaluation

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7 January 2021

The prospects for gene therapy in humans

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7 January 2021

Gene therapy and the ethics of genetic therapeutics

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7 January 2021

Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with a SV40 β-globin recombinant genome

1 reference

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7 January 2021

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase

1 reference

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7 January 2021

Gene transfer in intact animals

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7 January 2021

Insertion of a New Gene of Viral Origin into Bone Marrow Cells of Mice

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7 January 2021

Gene therapy pioneer draws Mikadoesque rap.

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7 January 2021

Gene Therapy Caught in More Entanglements

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7 January 2021

UCLA gene therapy racked by friendly fire

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7 January 2021

The DNA Provirus Hypothesis

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7 January 2021

Viral RNA-dependent DNA Polymerase: RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus

1 reference

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7 January 2021

RNA-dependent DNA polymerase in virions of RNA tumour viruses

1 reference

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7 January 2021

Construction and isolation of a transmissible retrovirus containing the src gene of Harvey murine sarcoma virus and the thymidine kinase gene of herpes simplex virus type 1

1 reference

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7 January 2021

Introduction of rat growth hormone gene into mouse fibroblasts via a retroviral DNA vector: expression and regulation

1 reference

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7 January 2021

A safe packaging line for gene transfer: separating viral genes on two different plasmids

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7 January 2021

Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyl transferase

1 reference

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7 January 2021

A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT

1 reference

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7 January 2021

Correction of adenosine deaminase deficiency in cultured human T and B cells by retrovirus-mediated gene transfer

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7 January 2021

Implantation of genetically engineered fibroblasts into mice: implications for gene therapy

1 reference

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7 January 2021

Clonal gene therapy: transplanted mouse fibroblast clones express human alpha 1-antitrypsin gene in vivo

1 reference

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7 January 2021

Efficient retrovirus-mediated transfer and expression of a human adenosine deaminase gene in diploid skin fibroblasts from an adenosine deaminase-deficient human

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7 January 2021

An alternative approach to somatic cell gene therapy

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7 January 2021

Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression

1 reference

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7 January 2021

Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease

1 reference

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7 January 2021

Expression of a retrovirus encoding human HPRT in mice

1 reference

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7 January 2021

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

1 reference

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7 January 2021

Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells

1 reference

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7 January 2021

Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cells in vivo

1 reference

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7 January 2021

Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes

1 reference

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7 January 2021

Retroviral gene transfer into primary hepatocytes: implications for genetic therapy of liver-specific functions

1 reference

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7 January 2021

Expression of an exogenous growth hormone gene by transplantable human epidermal cells

1 reference

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7 January 2021

Implantation of Recombinant Rat Myocytes into Adult Skeletal Muscle: A Potential Gene Therapy

1 reference

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7 January 2021

Systemic delivery of recombinant proteins by genetically modified myoblasts

1 reference

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7 January 2021

Systemic delivery of human growth hormone by injection of genetically engineered myoblasts.

1 reference

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7 January 2021

Recombinant gene expression in vivo within endothelial cells of the arterial wall

1 reference

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7 January 2021

Implantation of vascular grafts lined with genetically modified endothelial cells

1 reference

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7 January 2021

Site-specific gene expression in vivo by direct gene transfer into the arterial wall

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7 January 2021

Moral problems and ethical issues in prospective human gene therapy.

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7 January 2021

Adenosine-deaminase deficiency in two patients with severely impaired cellular immunity

1 reference

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7 January 2021

An in vivo model of somatic cell gene therapy for human severe combined immunodeficiency

1 reference

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7 January 2021

Efficient expression of retroviral vector-transduced human low density lipoprotein (LDL) receptor in LDL receptor-deficient rabbit fibroblasts in vitro

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

Long-Term Improvement of Hypercholesterolemia After Ex Vivo Gene Therapy in LDLR-Deficient Rabbits

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7 January 2021

Molecular basis of alpha 1-antitrypsin deficiency and its potential therapy by gene transfer

1 reference

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7 January 2021

Adenovirus-mediated transfer of a recombinant alpha 1-antitrypsin gene to the lung epithelium in vivo

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

Expression of human alpha 1-antitrypsin in dogs after autologous transplantation of retroviral transduced hepatocytes

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

Phenotypic correction of factor IX deficiency in skin fibroblasts of hemophilic dogs

1 reference

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7 January 2021

Circulating human or canine factor IX from retrovirally transduced primary myoblasts and established myoblast cell lines grafted into murine skeletal muscle

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

Expression of human factor IX in rat capillary endothelial cells: toward somatic gene therapy for hemophilia B

1 reference

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7 January 2021

Gaucher disease: new molecular approaches to diagnosis and treatment

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7 January 2021

Gene therapy techniques

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7 January 2021

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure

1 reference

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7 January 2021

Direct gene transfer into mouse muscle in vivo

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https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

Specific inhibition of human immunodeficiency virus type 1 replication by RNA transcribed in sense and antisense orientation from the 5'-leader/gag region

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7 January 2021

Adeno-associated virus general transduction vectors: analysis of proviral structures

1 reference

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7 January 2021

A defective HSV-1 vector expresses Escherichia coli beta-galactosidase in cultured peripheral neurons

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

Treatment of established renal cancer by tumor cells engineered to secrete interleukin-4.

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy

1 reference

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7 January 2021

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

Efficient incorporation of human CD4 protein into avian leukosis virus particles

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

Resistance to human immunodeficiency virus type 1 (HIV-1) infection in human CD4+ lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme.

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

Activation of a Diphtheria Toxin A Gene by Expression of Human Immunodeficiency Virus-1 Tat and Rev Proteins in Transfected Cells

1 reference

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7 January 2021

Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

HIV-1 Neutralizing Antibody and Approaches to the Envelope Diversity Problem

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

AIDS vaccines: progress and unmet challenges

1 reference

https://api.crossref.org/works/10.1038%2FNG1092-93

7 January 2021

Identifiers

DOI

10.1038/NG1092-93

1 reference

Dimensions Publication ID

7 August 2017

1022345654

0 references

1 reference