Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase (Q35199381)

7 August 2017

title

Dpb11 protein helps control assembly of the Cdc45·Mcm2-7·GINS replication fork helicase (English)

1 reference

7 August 2017

Daniel L Kaplan

5

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Irina Bruck

series ordinal

2

object named as

Irina Bruck

1 reference

7 August 2017

Nalini Dhingra

1

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7 August 2017

Skye Smith

series ordinal

3

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7 August 2017

Boting Ning

series ordinal

4

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7 August 2017

language of work or name

English

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publication date

6 February 2015

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Journal of Biological Chemistry

7 August 2017

published in

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7 August 2017

volume

290

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7 August 2017

issue

12

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7 August 2017

page(s)

7586-7601

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The Dbf4-Cdc7 kinase promotes Mcm2-7 ring opening to allow for single-stranded DNA extrusion and helicase assembly

7 August 2017

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Structural and mechanistic insights into Mcm2-7 double-hexamer assembly and function

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DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.

13 July 2018

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A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2-7 onto DNA

13 July 2018

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Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication

13 July 2018

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Origin plasticity during budding yeast DNA replication in vitro.

13 July 2018

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The replication initiation protein Sld2 regulates helicase assembly

13 July 2018

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Efficient initiation of DNA replication in eukaryotes requires Dpb11/TopBP1-GINS interaction

13 July 2018

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Cdc45 protein-single-stranded DNA interaction is important for stalling the helicase during replication stress

13 July 2018

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Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

13 July 2018

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Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase.

13 July 2018

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Enabling association of the GINS protein tetramer with the mini chromosome maintenance (Mcm)2-7 protein complex by phosphorylated Sld2 protein and single-stranded origin DNA.

13 July 2018

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Eukaryotic origin-dependent DNA replication in vitro reveals sequential action of DDK and S-CDK kinases.

13 July 2018

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Origin single-stranded DNA releases Sld3 protein from the Mcm2-7 complex, allowing the GINS tetramer to bind the Mcm2-7 complex

13 July 2018

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The structural basis for MCM2-7 helicase activation by GINS and Cdc45.

13 July 2018

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GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding

13 July 2018

1 reference

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Sld2 binds to origin single-stranded DNA and stimulates DNA annealing

13 July 2018

1 reference

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Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7

13 July 2018

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How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

13 July 2018

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The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 'gate'.

13 July 2018

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CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeast

13 July 2018

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The Dbf4-Cdc7 kinase promotes S phase by alleviating an inhibitory activity in Mcm4

13 July 2018

1 reference

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A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

13 July 2018

1 reference

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Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

13 July 2018

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Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability.

13 July 2018

1 reference

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The Mcm2-7 complex has in vitro helicase activity.

13 July 2018

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Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.

13 July 2018

1 reference

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CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367264

Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin

13 July 2018

1 reference

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Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367264

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367264

A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367264

Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367264

GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367264

Mcm4,6,7 uses a "pump in ring" mechanism to unwind DNA by steric exclusion and actively translocate along a duplex.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367264

Reconstitution of the Mcm2-7p heterohexamer, subunit arrangement, and ATP site architecture.

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367264

The Xenopus Xmus101 protein is required for the recruitment of Cdc45 to origins of DNA replication

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367264

Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367264

Premature structural changes at replication origins in a yeast minichromosome maintenance (MCM) mutant

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367264

Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint

13 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4367264

Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

13 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M115.640383

Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M115.640383

Origin association of Sld3, Sld7, and Cdc45 proteins is a key step for determination of origin-firing timing

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M115.640383

21 January 2018

Identifiers

DOI

10.1074/JBC.M115.640383

1 reference

7 August 2017

1 reference

7 August 2017

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