Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function. (Q35161675)

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English	Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function.	scientific article

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30 January 2020

Forebrain striatal-specific expression of mutant huntingtin protein in vivo induces cell-autonomous age-dependent alterations in sensitivity to excitotoxicity and mitochondrial function (English)

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30 January 2020

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Damian M Cummings

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30 January 2020

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Soong Ho Kim

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30 January 2020

Carlos A Thomas

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30 January 2020

Véronique M André

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30 January 2020

Carlos Cepeda

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30 January 2020

Michael S Levine

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30 January 2020

Michelle E Ehrlich

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7 June 2011

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30 January 2020

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30 January 2020

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30 January 2020

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30 January 2020

e00060

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30 January 2020

In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons

1 reference

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13 July 2018

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

1 reference

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13 July 2018

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis

1 reference

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13 July 2018

Alterations in striatal synaptic transmission are consistent across genetic mouse models of Huntington's disease

1 reference

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13 July 2018

In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease subjects

1 reference

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13 July 2018

Genetic mouse models of Huntington's disease: focus on electrophysiological mechanisms

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13 July 2018

Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

1 reference

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13 July 2018

Location, location, location: contrasting roles of synaptic and extrasynaptic NMDA receptors in Huntington's disease

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13 July 2018

Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice

1 reference

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13 July 2018

Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms

1 reference

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13 July 2018

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

1 reference

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13 July 2018

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

1 reference

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13 July 2018

Mitochondrial calcium function and dysfunction in the central nervous system

1 reference

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13 July 2018

Age-dependent alterations of corticostriatal activity in the YAC128 mouse model of Huntington disease

1 reference

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13 July 2018

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease

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13 July 2018

Neocortical expression of mutant huntingtin is not required for alterations in striatal gene expression or motor dysfunction in a transgenic mouse

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13 July 2018

The dichotomy of NMDA receptor signaling.

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13 July 2018

A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse

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13 July 2018

Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease

1 reference

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13 July 2018

Extended polyglutamine repeats trigger a feedback loop involving the mitochondrial complex III, the proteasome and huntingtin aggregates

1 reference

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13 July 2018

N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

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13 July 2018

The corticostriatal pathway in Huntington's disease

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13 July 2018

Selective neuronal degeneration in Huntington's disease

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13 July 2018

Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors.

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13 July 2018

Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin

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13 July 2018

Alterations in N-methyl-D-aspartate receptor sensitivity and magnesium blockade occur early in development in the R6/2 mouse model of Huntington's disease

1 reference

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13 July 2018

The toxic effect of sodium L-glutamate on the inner layers of the retina.

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13 July 2018

Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32

1 reference

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13 July 2018

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.

1 reference

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13 July 2018

Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene

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13 July 2018

Striatal volume loss in HD as measured by MRI and the influence of CAG repeat

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13 July 2018

Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse.

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13 July 2018

Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity

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13 July 2018

Anterograde transport of brain-derived neurotrophic factor and its role in the brain

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13 July 2018

Targeted inactivation of the mouse Huntington's disease gene homolog Hdh.

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13 July 2018

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

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13 July 2018

Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration

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13 July 2018

Bioenergetics and glutamate excitotoxicity

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13 July 2018

Oxidative stress, glutamate, and neurodegenerative disorders

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13 July 2018

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

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13 July 2018

Inactivation of the mouse Huntington's disease gene homolog Hdh

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13 July 2018

Biochemical abnormalities in Huntington's chorea brains

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13 July 2018

The efficiency of systematic sampling in stereology and its prediction.

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13 July 2018

Regional mitochondrial respiratory activity in Huntington's disease brain

1 reference

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13 July 2018

Neuropathological classification of Huntington's disease

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13 July 2018

Excitatory amino acid receptors in the vertebrate central nervous system

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13 July 2018

Evidence for a defect in NADH: ubiquinone oxidoreductase (complex I) in Huntington's disease

1 reference

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13 July 2018

Mitochondrial function and parental sex effect in Huntington's disease

1 reference

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13 July 2018

Effects of aging on quinolinic acid lesions in rat striatum

1 reference

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13 July 2018

Excitotoxic injury of the neostriatum: a model for Huntington's disease

1 reference

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13 July 2018

Kainate-induced degeneration of neostriatal neurons: dependency upon corticostriatal tract

1 reference

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13 July 2018

Neuropeptide Y modifies the disease course in the R6/2 transgenic model of Huntington's disease

1 reference

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27 September 2018

Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats

1 reference

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27 September 2018

Dopamine modulation of excitatory currents in the striatum is dictated by the expression of D1 or D2 receptors and modified by endocannabinoids.

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27 September 2018

In vivo evidence for NMDA receptor-mediated excitotoxicity in a murine genetic model of Huntington disease.

1 reference

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27 September 2018

Neuronal viability is controlled by a functional relation between synaptic and extrasynaptic NMDA receptors.

1 reference

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27 September 2018

Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II.

1 reference

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27 September 2018

Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95.

1 reference

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27 September 2018

Differential susceptibility to striatal neurodegeneration induced by quinolinic acid and kainate in inbred, outbred and hybrid mouse strains

1 reference

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27 September 2018

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

1 reference

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27 September 2018

Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

1 reference

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27 September 2018

Cytotoxicity of a mutant huntingtin fragment in yeast involves early alterations in mitochondrial OXPHOS complexes II and III.

1 reference

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27 September 2018

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

1 reference

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27 September 2018

Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease

1 reference

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27 September 2018

p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease

1 reference

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27 September 2018

Striatal potassium channel dysfunction in Huntington's disease transgenic mice

1 reference

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27 September 2018

Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease

1 reference

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27 September 2018

Increased GABAergic function in mouse models of Huntington's disease: reversal by BDNF.

1 reference

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27 September 2018

Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington's mouse model

1 reference

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27 September 2018

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155197

27 September 2018

Transient and progressive electrophysiological alterations in the corticostriatal pathway in a mouse model of Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155197

27 September 2018

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155197

27 September 2018

Immediate-early gene response to methamphetamine, haloperidol, and quinolinic acid is not impaired in Huntington's disease transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155197

27 September 2018

NMDA receptor function in mouse models of Huntington disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155197

27 September 2018

A dopamine/D1 receptor/protein kinase A/dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa)/protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155197

27 September 2018

Trinucleotide (CAG) repeat length is positively correlated with the degree of DNA fragmentation in Huntington's disease striatum

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155197

27 September 2018

Complex I defect in muscle from patients with Huntington's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155197

27 September 2018

Dopaminergic modulation of NMDA-induced whole cell currents in neostriatal neurons in slices: contribution of calcium conductances

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155197

27 September 2018

Aging reduces neostriatal responsiveness to N-methyl-D-aspartate and dopamine: an in vitro electrophysiological study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155197

27 September 2018

Mitochondrial defect in Huntington's disease caudate nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3155197

27 September 2018

Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors

1 reference

https://api.crossref.org/works/10.1042%2FAN20110009

21 January 2018

A microcolorimetric method for the determination of inorganic phosphorus

1 reference

https://pubmed.ncbi.nlm.nih.gov/21542802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization

1 reference

https://pubmed.ncbi.nlm.nih.gov/21542802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/21542802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay of ATPase and Na,K-ATPase activity using high-performance liquid chromatographic determination of ADP derived from ATP

1 reference

https://pubmed.ncbi.nlm.nih.gov/21542802

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1042/AN20110009

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21542802%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

release_iyjitkocqbf3rgyg74geg4oucm

1 reference

https://api.fatcat.wiki/v0/release/iyjitkocqbf3rgyg74geg4oucm

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21542802%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21542802%20AND%20SRC:MED&resulttype=core&format=json

30 January 2020

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