Causative and susceptibility genes for Alzheimer's disease: a review. (Q35146030)

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4 November 2019

review article

1 reference

title

Causative and susceptibility genes for Alzheimer's disease: a review (English)

1 reference

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4 November 2019

0 references

3

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4 November 2019

author name string

A Rocchi

series ordinal

1

1 reference

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4 November 2019

S Pellegrini

series ordinal

2

1 reference

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4 November 2019

L Murri

series ordinal

4

1 reference

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4 November 2019

publication date

1 June 2003

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4 November 2019

published in

Brain Research Bulletin

1 reference

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4 November 2019

volume

61

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4 November 2019

issue

1

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4 November 2019

page(s)

1-24

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Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

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The --491 TT apolipoprotein E promoter polymorphism is associated with reduced risk for sporadic Alzheimer's disease.

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A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch.

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Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

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Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease

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Imaging amyloid-beta deposits in vivo

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Cathepsin D polymorphism in Italian sporadic and familial Alzheimer's disease

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Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity

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Evidence for genetic linkage of Alzheimer's disease to chromosome 10q

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No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease.

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7 January 2021

Alzheimer's disease and the cystatin C gene polymorphism: an association study.

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7 January 2021

Genetic polymorphisms in the cathespin D and interleukin-6 genes and the risk of Alzheimer's disease.

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7 January 2021

Alpha-2 macroglobulin is genetically associated with Alzheimer disease

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7 January 2021

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease.

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7 January 2021

Biochemical Assessment of Serotonergic and Cholinergic Dysfunction and Cerebral Atrophy in Alzheimer's Disease

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7 January 2021

Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease

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7 January 2021

Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization

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7 January 2021

A mutation in codon 717 of the amyloid precursor protein gene in an Australian family with Alzheimer's disease.

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7 January 2021

A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.

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7 January 2021

No founder effect in three novel Alzheimer's disease families with APP 717 Val-->Ile mutation. Clerget-darpoux. French Alzheimer's Disease Study Group.

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

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No association detected between very-low-density lipoprotein receptor (VLDL-R) and late-onset Alzheimer's disease in Hong Kong Chinese.

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Study of the association between Alzheimer's disease and angiotensin-converting enzyme gene polymorphism using DNA from lymphocytes.

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Expression of the very low-density lipoprotein receptor (VLDL-r), an apolipoprotein-E receptor, in the central nervous system and in Alzheimer's disease.

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7 January 2021

Lack of association of trinucleotide repeat polymorphisms in very-low-density lipoprotein receptor gene with Alzheimer's disease.

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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7 January 2021

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

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7 January 2021

Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele?

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7 January 2021

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

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7 January 2021

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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7 January 2021

The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations

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7 January 2021

The genetic association between Cathepsin D and Alzheimer's disease.

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7 January 2021

A polymorphism in the cystatin C gene is a novel risk factor for late-onset Alzheimer's disease.

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7 January 2021

A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1.

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Serotonin receptor changes in dementia of the Alzheimer type.

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Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease

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7 January 2021

Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1.

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7 January 2021

Selective loss of central cholinergic neurons in Alzheimer's disease

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Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased Abeta42 secretion.

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Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

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Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's Disease

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Alpha-2 macroglobulin polymorphism and Alzheimer disease risk in the UK.

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Localization of neuronal and endothelial nitric oxide synthase isoforms in human hippocampus

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7 January 2021

A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

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Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

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SNP association studies in Alzheimer's disease highlight problems for complex disease analysis.

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7 January 2021

Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

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7 January 2021

Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23→q25

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7 January 2021

No association between the very low density lipoprotein receptor gene and late-onset Alzheimer's disease nor interaction with the apolipoprotein E gene in population-based and clinic samples

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7 January 2021

Association between bleomycin hydrolase and Alzheimer's disease in caucasians

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Association Between Angiotensin-Converting Enzyme and Alzheimer Disease

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7 January 2021

Screening for mutations in the open reading frame and promoter of the beta-amyloid precursor protein gene in familial Alzheimer's disease: identification of a further family with APP717 Val-->Ile

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7 January 2021

High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes

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7 January 2021

Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease.

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7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

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7 January 2021

Lack of association of the alpha2-macroglobulin locus on chromosome 12 in AD.

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7 January 2021

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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7 January 2021

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

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7 January 2021

Ultrastructural localization of butyrylcholinesterase on neurofibrillary degeneration sites in the brains of aged and Alzheimer's disease patients

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7 January 2021

Ultrastructural localization of butyrylcholinesterase in senile plaques in the brains of aged and Alzheimer disease patients

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7 January 2021

Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy

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7 January 2021

Butyrylcholinesterase in the life cycle of amyloid plaques

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7 January 2021

The presenilins in Alzheimer's disease--proteolysis holds the key.

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7 January 2021

Association of APOE promoter but not A2M polymorphisms with risk of developing Alzheimer's disease.

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7 January 2021

Amyloid, the presenilins and Alzheimer's disease

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7 January 2021

Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population.

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7 January 2021

Very low density lipoprotein receptor in Alzheimer disease

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7 January 2021

The very low density lipoprotein (VLDL) receptor is a genetic susceptibility factor for Alzheimer disease in a European Caucasian population.

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7 January 2021

Promoter polymorphism (-491A/T) in the APOE gene of Finnish Alzheimer's disease patients and control individuals.

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7 January 2021

Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

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7 January 2021

Butyrylcholinesterase K variant and apolipoprotein E4 genes do not act in synergy in Finnish late-onset Alzheimer's disease patients

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7 January 2021

Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease

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7 January 2021

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

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7 January 2021

Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); retards A beta aggregation, deposition, fibril formation; and inhibits cytotoxicity

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7 January 2021

Angiotensin-converting enzyme genotype is associated with Alzheimer disease in the Japanese population

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7 January 2021

Promoter polymorphism of the 5-HT transporter and Alzheimer's disease.

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7 January 2021

Inflammatory mechanisms in Alzheimer's disease

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7 January 2021

Transferrin gene polymorphism in Alzheimer's disease and dementia with Lewy bodies in humans.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Increased beta-amyloid release and levels of amyloid precursor protein (APP) in fibroblast cell lines from family members with the Swedish Alzheimer's disease APP670/671 mutation.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Variation in DCP1, encoding ACE, is associated with susceptibility to Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Degradation of tau by lysosomal enzyme cathepsin D: implication for Alzheimer neurofibrillary degeneration.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Aph-2/Nicastrin: an essential component of gamma-secretase and regulator of Notch signaling and Presenilin localization

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: no evidence for an association.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Contribution of APOE promoter polymorphisms to Alzheimer's disease risk

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Is the LDL receptor-related protein involved in Alzheimer's disease?

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The transcriptional factor LBP-1c/CP2/LSF gene on chromosome 12 is a genetic determinant of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The -48 C/T polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimer's disease and an increased Abeta load in brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

A novel mutation in the predicted TM2 domain of the presenilin 2 gene in a Spanish patient with late-onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

No association between butyrylcholinesterase K-variant and Alzheimer disease in Chinese

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Codeposition of cystatin C with amyloid-beta protein in the brain of Alzheimer disease patients

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Candidate gene for the chromosome 1 familial Alzheimer's disease locus

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimerʼs disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Increased levels of alpha-1-antichymotrypsin in brains of patients with Alzheimer's disease correlate with activated astrocytes and are affected by APOE 4 genotype

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Apolipoprotein E and alpha-1-antichymotrypsin allele polymorphism in sporadic and familial Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Gene polymorphism affecting α1-antichymotrypsin and interleukin-1 plasma levels increases Alzheimer's disease risk

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Serum alpha 1-antichymotrypsin level as a marker for Alzheimer-type dementia.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

A novel presenilin 2 gene mutation (D439A) in a patient with early-onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Analysis of genetic polymorphisms in the transforming growth factor-beta1 gene and the risk of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Regional mapping of human chromosome 19: organization of genes for plasma lipid transport (APOC1, -C2, and -E and LDLR) and the genes C3, PEPD, and GPI.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Apolipoprotein E: far more than a lipid transport protein

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Alzheimer's disease and Down's syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The pathological association between Down syndrome and Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

An intronic polymorphism in the presenilin-1 gene does not influence the amount or molecular form of the amyloid beta protein deposited in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Lack of an association between cystatin C gene polymorphisms in Japanese patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Lack of association between cathepsin D genetic polymorphism and Alzheimer disease in a Spanish sample

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Alpha 1-antichymotrypsin as a possible biochemical marker for Alzheimer-type dementia

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Japanese siblings with missense mutation (717Val --> Ile) in amyloid precursor protein of early-onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Dipeptidyl carboxypeptidase 1 (DCP1) and butyrylcholinesterase (BCHE) gene interactions with the apolipoprotein E epsilon4 allele as risk factors in Alzheimer's disease and in Parkinson's disease with coexisting Alzheimer pathology

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Cathepsin D gene exon 2 polymorphism and sporadic Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Common polymorphisms in LRP and A2M do not affect genetic risk for Alzheimer disease in Northern Ireland.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Risk of Alzheimer's disease is associated with a very low-density lipoprotein receptor genotype in Northern Ireland.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

An association study of polymorphisms in the alpha-antichymotrypsin gene for Alzheimer disease in Han-Chinese

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Non-replication of association between cathepsin D genotype and late onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Polymorphism in the alpha(1)-antichymotrypsin (ACT) gene promoter: effect on expression in transfected glial and liver cell lines and plasma ACT concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Microsatellite polymorphism of the alpha 1-antichymotrypsin gene locus associated with sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Untangling Alzheimer's disease from fibrous lesions of neurofibrillary tangles and senile plaques

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Direct association of presenilin-1 with beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Early-onset Alzheimer disease caused by a new mutation (V717L) in the amyloid precursor protein gene

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Susceptibility locus for Alzheimer's disease on chromosome 10.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

α2-Macroglobulin polymorphisms in Italian sporadic and familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Bleomycin hydrolase immunoreactivity in senile plaque in the brains of patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Association of transferrin C2 allele with late-onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The ACE gene and Alzheimer's disease susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Single nucleotide polymorphisms of the very low density lipoprotein receptor (VLDLR) gene

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein G(o)

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Lack of association of very low density lipoprotein receptor gene polymorphism with Caucasian Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The locus for apolipoprotein E (apoE) is linked to the complement component C3 (C3) locus on chromosome 19 in man

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Butyrycholinesterase K variant and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Confirmation of the association between bleomycin hydrolase genotype and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

An Iranian family with Alzheimer's disease caused by a novel APP mutation (Thr714Ala).

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Changes in brain cholinesterases in senile dementia of Alzheimer type

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Distribution of the Protease Inhibitor α1-Antichymotrypsin in Cerebral and Systemic Amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The neurometabolic landscape of cognitive decline: in vivo studies with positron emission tomography in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

The inflammation-induced pathological chaperones ACT and apo-E are necessary catalysts of Alzheimer amyloid formation

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Structure and alternative splicing of the presenilin-2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

No association between very low density lipoprotein receptor (VLDL-R) and Alzheimer disease in American Caucasians.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Regional location of alpha 1-antichymotrypsin and alpha 1-antitrypsin genes on human chromosome 14

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Effect of the APOE-491A/T promoter polymorphism on apolipoprotein E levels and risk of Alzheimer disease: The Rotterdam Study

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Acute phase proteins are present in amorphous plaques in the cerebral but not in the cerebellar cortex of patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Alpha-2 macroglobulin gene and Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

In vitro processing of amyloid precursor protein by cathepsin D.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0361-9230%2803%2900067-4

7 January 2021

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

1 reference

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7 January 2021

Beta-catenin expression in human neural cell lines following exposure to cytokines and growth factors.

1 reference

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7 January 2021

The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.

1 reference

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7 January 2021

Genetic associations with human longevity at the APOE and ACE loci

1 reference

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7 January 2021

Polymorphism of the angiotensin-converting enzyme gene and cardiovascular disease

1 reference

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7 January 2021

Normal and abnormal biology of the beta-amyloid precursor protein

1 reference

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7 January 2021

Genes and susceptible loci of Alzheimer's disease

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

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7 January 2021

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

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7 January 2021

No association between the K variant of the butyrylcholinesterase gene and pathologically confirmed Alzheimer's disease.

1 reference

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7 January 2021

Alpha2-macroglobulin polymorphism is not associated with AD or AD-type neuropathology in the Japanese.

1 reference

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7 January 2021

APP717 and Alzheimer's disease in Italy.

1 reference

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7 January 2021

Epistatic effect of APP717 mutation and apolipoprotein E genotype in familial Alzheimer's disease

1 reference

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7 January 2021

The genetic defect causing familial Alzheimer's disease maps on chromosome 21.

1 reference

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7 January 2021

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

1 reference

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7 January 2021

Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

1 reference

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7 January 2021

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

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7 January 2021

Polymorphism in AACT gene may lower age of onset of Alzheimer's disease.

1 reference

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7 January 2021

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

1 reference

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7 January 2021

Genetic association of an LBP-1c/CP2/LSF gene polymorphism with late onset Alzheimer's disease

1 reference

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7 January 2021

Altered serotonin transporter sites in Alzheimerʼs disease raphe and hippocampus

1 reference

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7 January 2021

Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation

1 reference

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7 January 2021

Genetic variability in the regulatory region of presenilin 1 associated with risk for Alzheimer's disease and variable expression

1 reference

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7 January 2021

Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility

1 reference

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7 January 2021

Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors

1 reference

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7 January 2021

Polymorphisms of the human apolipoprotein E promoter and bleomycin hydrolase gene: risk factors for Alzheimer's dementia?

1 reference

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7 January 2021

Evaluation of polymorphisms in the presenilin-1 gene and the butyrylcholinesterase gene as risk factors in sporadic Alzheimer's disease

1 reference

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7 January 2021

Missense polymorphism (C/T224) in the human cathepsin D pro-fragment determined by polymerase chain reaction--single strand conformational polymorphism analysis and possible consequences in cancer cells

1 reference

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7 January 2021

Association study for a functional serotonin transporter gene polymorphism and late-onset Alzheimer's disease for Chinese patients

1 reference

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7 January 2021

A presenilin-1 truncating mutation is present in two cases with autopsy-confirmed early-onset Alzheimer disease

1 reference

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7 January 2021

Polymorphism of apolipoprotein E

1 reference

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7 January 2021

Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3

1 reference

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7 January 2021

APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease.

1 reference

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7 January 2021

Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis (Dutch)

1 reference

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7 January 2021

Genetic association of the presenilin-1 regulatory region with early-onset Alzheimer's disease in a population-based sample

1 reference

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7 January 2021

Increased frequency of the transferrin C2 subtype in Alzheimer's disease

1 reference

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7 January 2021

Earlier age of onset of Alzheimer's disease in patients with both the transferrin C2 and apolipoprotein E-epsilon 4 alleles.

1 reference

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7 January 2021

The synthesis and transport of lipids for axonal growth and nerve regeneration

1 reference

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7 January 2021

Use of haplotype information to test involvement of the LRP gene in Alzheimer's disease in the French population

1 reference

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7 January 2021

Nerve growth factor modulates the expression and secretion of beta-amyloid precursor protein through different mechanisms in PC12 cells

1 reference

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7 January 2021

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

1 reference

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7 January 2021

Genetic variation in alpha(1)-antichymotrypsin and its association with Alzheimer's disease

1 reference

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7 January 2021

Lack of association between alpha2-macroglobulin polymorphisms and Alzheimer's disease.

1 reference

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7 January 2021

Microvascular degeneration in hereditary cystatin C amyloid angiopathy of the brain.

1 reference

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7 January 2021

Constitutive secretion of cystatin C (gamma-trace) by monocytes and macrophages and its downregulation after stimulation

1 reference

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7 January 2021

Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease.

1 reference

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7 January 2021

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

1 reference

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7 January 2021

The role of beta-catenin stability in mutant PS1-associated apoptosis

1 reference

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7 January 2021

Further evidence for a synergistic association between APOE epsilon4 and BCHE-K in confirmed Alzheimer's disease

1 reference

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7 January 2021

Apolipoprotein E: structure-function relationships

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7 January 2021

Alzheimer's disease in Down's syndrome: clinicopathologic studies

1 reference

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

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7 January 2021

Effects of transferrin genetic phenotypes on total iron-binding capacity

1 reference

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7 January 2021

Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group

1 reference

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7 January 2021

Regulatory role of brain angiotensins in the control of physiological and behavioral responses

1 reference

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7 January 2021

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

1 reference

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7 January 2021

Genetic risk factors in Japanese Alzheimer's disease patients: alpha1-ACT, VLDLR, and ApoE.

1 reference

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7 January 2021

Association between angiotensin-converting enzyme gene and late onset Alzheimer's disease in Han chinese.

1 reference

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7 January 2021

alpha 1-Antichymotrypsin as a risk modifier for late-onset Alzheimer's disease in Japanese apolipoprotein E epsilon 4 allele carriers.

1 reference

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7 January 2021

Genomic organization of the human amyloid beta-protein precursor gene

1 reference

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7 January 2021

The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups

1 reference

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7 January 2021

Screening of the mis-sense mutation producing the 717Val-->Ile substitution in the amyloid precursor protein in Japanese familial and sporadic Alzheimer's disease

1 reference

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7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

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7 January 2021

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

1 reference

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7 January 2021

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1 reference

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7 January 2021

Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patients.

1 reference

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7 January 2021

10.1016/S0361-9230(03)00067-4

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12788204%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference