Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates (Q35133872)

6 August 2017

title

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates (English)

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6 August 2017

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5

Michael Karin

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6 August 2017

Giovanni Solinas

1

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ORCID Public Data File 2021

author name string

Willscott Naugler

series ordinal

2

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6 August 2017

Francesco Galimi

series ordinal

3

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6 August 2017

Myung-Shik Lee

series ordinal

4

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6 August 2017

language of work or name

English

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publication date

18 October 2006

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Proceedings of the National Academy of Sciences of the United States of America

6 August 2017

published in

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6 August 2017

volume

103

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6 August 2017

issue

44

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6 August 2017

page(s)

16454-16459

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Islet beta cell failure in type 2 diabetes

6 August 2017

cites work

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Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

28 July 2018

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice

28 July 2018

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28 July 2018

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28 July 2018

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27 September 2018

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Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide

27 September 2018

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Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

27 September 2018

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Repeated fasting stress causes activation of mitogen-activated protein kinases (ERK/JNK) in rat liver.

27 September 2018

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27 September 2018

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

27 September 2018

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Short-term regulation of insulin gene transcription by glucose

27 September 2018

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27 September 2018

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

27 September 2018

1 reference

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Nuclear Factor κB Protects Pancreatic β-Cells From Tumor Necrosis Factor-α-Mediated Apoptosis

27 September 2018

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https://pubmed.ncbi.nlm.nih.gov/17050683

12 December 2020

Insulin signaling in health and disease

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https://pubmed.ncbi.nlm.nih.gov/17050683

12 December 2020

Preparation of rat liver cells. I. Effect of Ca 2+ on enzymatic dispersion of isolated, perfused liver

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https://pubmed.ncbi.nlm.nih.gov/17050683

12 December 2020

Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels

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https://pubmed.ncbi.nlm.nih.gov/17050683

12 December 2020

The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity

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https://pubmed.ncbi.nlm.nih.gov/17050683

12 December 2020

Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis

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https://pubmed.ncbi.nlm.nih.gov/17050683

12 December 2020

Identifiers

DOI

10.1073/PNAS.0607626103

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6 August 2017

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6 August 2017

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