Multistep Tumorigenesis of Multiple Myeloma: Its Molecular Delineation (Q35121609)

6 August 2017

1 reference

title

Multistep tumorigenesis of multiple myeloma: its molecular delineation (English)

1 reference

https://api.crossref.org/works/10.1007/BF02983776

6 August 2017

Multistep Tumorigenesis of Multiple Myeloma: Its Molecular Delineation (English)

1 reference

30 December 2023

1 reference

Shinsuke Iida

1

1 reference

6 August 2017

Ryuzo Ueda

series ordinal

2

1 reference

6 August 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12731662

30 December 2023

publication date

1 April 2003

1 reference

full work available at URL

6 August 2017

http://link.springer.com/article/10.1007/BF02983776/fulltext.html

1 reference

https://api.crossref.org/works/10.1007/BF02983776

http://link.springer.com/content/pdf/10.1007/BF02983776.pdf

30 December 2023

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1007/BF02983776

http://link.springer.com/content/pdf/10.1007/BF02983776

30 December 2023

1 reference

https://api.crossref.org/works/10.1007/BF02983776

International Journal of Hematology

30 December 2023

published in

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6 August 2017

volume

77

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6 August 2017

issue

3

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6 August 2017

page(s)

207-212

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Lack of Ku80 alteration in multiple myeloma

6 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02983776

Ectopic expression of MAFB gene in human myeloma cells carrying (14;20)(q32;q11) chromosomal translocations

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FBF02983776

Expression of the bcl-2 gene in human multiple myeloma cell lines and normal plasma cells

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Concurrent activation of a novel putative transforming gene, myeov, and cyclin D1 in a subset of multiple myeloma cell lines with t(11;14)(q13;q32).

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

p16(INK4a) and p15(INK4b) gene methylations in plasma cells from monoclonal gammopathy of undetermined significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISH

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Results of high-dose therapy for 1000 patients with multiple myeloma: durable complete remissions and superior survival in the absence of chromosome 13 abnormalities

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Ku86 variant expression and function in multiple myeloma cells is associated with increased sensitivity to DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Mutational activation of N- and K-ras oncogenes in plasma cell dyscrasias

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

De novo methylation of tumor suppressor gene p16/INK4a is a frequent finding in multiple myeloma patients at diagnosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xL

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Multiple myeloma: high incidence of chromosomal aneuploidy as detected by interphase fluorescence in situ hybridization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Frequent hypermethylation of p16 and p15 genes in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

The t(4;14) translocation in myeloma dysregulates both FGFR3 and a novel gene, MMSET, resulting in IgH/MMSET hybrid transcripts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Centrosome aberrations: cause or consequence of cancer progression?

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

A novel human multiple myeloma-derived cell line, NCU-MM-1, carrying t(2;11)(q11;q23) and t(8;22)(q24;q11) chromosomal translocations with overexpression of c-Myc protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Transformation and plasmacytoid differentiation of EBV-infected human B lymphoblasts by ras oncogenes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Chromosome translocations in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Myeloid cell factor-1 is a critical survival factor for multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

The Ig heavy chain gene is frequently involved in chromosomal translocations in multiple myeloma and plasma cell leukemia as detected by in situ hybridization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Genomic abnormalities in monoclonal gammopathy of undetermined significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Overexpression of the myeloma-associated oncogene fibroblast growth factor receptor 3 confers dexamethasone resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Interphase fluorescence in situ hybridization identifies chromosomal abnormalities in plasma cells from patients with monoclonal gammopathy of undetermined significance

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Monosomy 13 is associated with the transition of monoclonal gammopathy of undetermined significance to multiple myeloma. Intergroupe Francophone du Myélome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Ectopic expression of fibroblast growth factor receptor 3 promotes myeloma cell proliferation and prevents apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Detection of MUM1/IRF4-IgH fusion in multiple myeloma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Dysregulation of cyclin D1 by translocation into an IgH gamma switch region in two multiple myeloma cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Alterations of the cyclin D1/pRb/p16(INK4A) pathway in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Hypermethylation of p16INK4A gene promoter during the progression of plasma cell dyscrasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Ras oncogene mutation in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

The AKT kinase is activated in multiple myeloma tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Presence of a p53 gene deletion in patients with multiple myeloma predicts for short survival after conventional-dose chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

A long-term study of prognosis in monoclonal gammopathy of undetermined significance.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Biologic sequelae of nuclear factor-kappaB blockade in multiple myeloma: therapeutic applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Multiple myeloma: evolving genetic events and host interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

14q32 translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a multistep process for the oncogenesis of multiple myeloma. Intergroupe Francophone du Myélome

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Chromosome 13 abnormalities identified by FISH analysis and serum beta2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

p53 gene mutations in multiple myeloma are associated with advanced forms of malignancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12731662

12 December 2020

https://api.crossref.org/works/10.1007/BF02983776

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30 December 2023

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30 December 2023

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30 December 2023

Identifiers

DOI

10.1007/BF02983776

1 reference

6 August 2017

1 reference