Janus kinase-3 dependent inflammatory responses in allergic asthma (Q35031161)

5 August 2017

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title

Janus kinase-3 dependent inflammatory responses in allergic asthma (English)

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5 August 2017

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1 reference

Rama Malaviya

1

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5 August 2017

Debra L Laskin

series ordinal

2

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5 August 2017

Ravi Malaviya

series ordinal

3

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5 August 2017

publication date

27 April 2010

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International Immunopharmacology

5 August 2017

published in

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5 August 2017

volume

10

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5 August 2017

issue

8

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5 August 2017

page(s)

829-836

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Genetics and pharmacogenetics of the leukotriene pathway

5 August 2017

cites work

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Macrophages and inflammatory mediators in chemical toxicity: a battle of forces

8 July 2018

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8 July 2018

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Selectivity and therapeutic inhibition of kinases: to be or not to be?

8 July 2018

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Janus kinases in immune cell signaling

8 July 2018

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GANP suppresses the arginine methyltransferase PRMT5 regulating IL-4-mediated STAT6-signaling to IgE production in B cells

8 July 2018

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Complement production and regulation by dendritic cells: molecular switches between tolerance and immunity

8 July 2018

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Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity

8 July 2018

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New insights on mast cell activation via the high affinity receptor for IgE

8 July 2018

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Lung dendritic cells: targets for therapy in allergic disease

8 July 2018

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Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma

8 July 2018

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Subspecialty differences in asthma characteristics and management

8 July 2018

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A review of anti-IgE monoclonal antibody (omalizumab) as add on therapy for severe allergic (IgE-mediated) asthma

8 July 2018

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Mast cell activators: a new class of highly effective vaccine adjuvants

8 July 2018

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Progress in allergy signal research on mast cells: signal regulation of multiple mast cell responses through FcepsilonRI.

8 July 2018

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Dendritic cells in chronic obstructive pulmonary disease: new players in an old game

8 July 2018

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Regulation of mast cell development by inflammatory factors

8 July 2018

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Janus kinase 3 inhibitor WHI-P154 in macrophages activated by bacterial endotoxin: differential effects on the expression of iNOS, COX-2 and TNF-alpha.

8 July 2018

1 reference

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Sequential activation of JAKs, STATs and xanthine dehydrogenase/oxidase by hypoxia in lung microvascular endothelial cells

8 July 2018

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Altered phosphorylated signal transducer and activator of transcription profile of CD4+CD161+ T cells in asthma: modulation by allergic status and oral corticosteroids

8 July 2018

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Dendritic cells in allergic airway inflammation

8 July 2018

1 reference

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Kaempferol inhibits IL-4-induced STAT6 activation by specifically targeting JAK3.

8 July 2018

1 reference

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Syk deficiency in human non-releaser lung mast cells

8 July 2018

1 reference

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Syk inhibitors as treatment for allergic rhinitis

8 July 2018

1 reference

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Different approaches to study mast cell functions

8 July 2018

1 reference

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JAK inhibitors AG-490 and WHI-P154 decrease IFN-gamma-induced iNOS expression and NO production in macrophages

8 July 2018

1 reference

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Development, migration, and survival of mast cells

8 July 2018

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Molecular regulation of mast cell activation

8 July 2018

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Anti-IgE as a mast cell-stabilizing therapeutic agent

8 July 2018

1 reference

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TGF-beta: its role in asthma and therapeutic potential

8 July 2018

1 reference

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Biology of mast cell tryptase. An inflammatory mediator

8 July 2018

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Thymic stromal lymphopoietin: master switch for allergic inflammation

8 July 2018

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The contribution of transforming growth factor-beta and epidermal growth factor signalling to airway remodelling in chronic asthma

8 July 2018

1 reference

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Anti-IgE (omalizumab) inhibits late-phase reactions and inflammatory cells after repeat skin allergen challenge

8 July 2018

1 reference

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Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity

8 July 2018

1 reference

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Anti-immunoglobulin E treatment with omalizumab in allergic diseases: an update on anti-inflammatory activity and clinical efficacy

8 July 2018

1 reference

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Mast cells and basophils: friends as well as foes in bronchial asthma?

8 July 2018

1 reference

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A signal transducer and activator of transcription 6 haplotype influences the regulation of serum IgE levels

8 July 2018

1 reference

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Interleukin-4 receptor signaling pathways in asthma pathogenesis

8 July 2018

1 reference

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Cytokine-directed therapy in asthma

8 July 2018

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Janus kinase-3 (JAK3) inhibition: a novel immunosuppressive option for allogeneic transplantation

8 July 2018

1 reference

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T-cell trafficking in asthma: lipid mediators grease the way.

8 July 2018

1 reference

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CD40/CD154 interactions at the interface of tolerance and immunity

8 July 2018

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Mast cells and eosinophils: the hallmark of asthma

8 July 2018

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CD40 on adult human airway epithelial cells: expression and proinflammatory effects.

8 July 2018

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Biology and therapeutic potential of the interleukin-4/interleukin-13 signaling pathway in asthma

8 July 2018

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The role of mast cells in asthma

8 July 2018

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Airway remodeling in asthma: new insights

8 July 2018

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Airway inflammation and remodeling in asthma: current concepts

8 July 2018

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JAK-STAT signaling in asthma

8 July 2018

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Regulation of mast cell-mediated innate immunity during early response to bacterial infection

8 July 2018

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CD40 employs p38 MAP kinase in IgE isotype switching

8 July 2018

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The anti-inflammatory effects of leukotriene-modifying drugs and their use in asthma

8 July 2018

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Role of dendritic cells and Th2 lymphocytes in asthma: lessons from eosinophilic airway inflammation in the mouse

8 July 2018

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Regulation of the inflammatory response in asthma by mast cell products

8 July 2018

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Activation of the mouse Ig germline epsilon promoter by IL-4 is dependent on AP-1 transcription factors

8 July 2018

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8 July 2018

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Biologic functions and signaling of the interleukin-4 receptor complexes

8 July 2018

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Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice

8 July 2018

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8 July 2018

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8 July 2018

Mast cells and basophils

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Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis

8 July 2018

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The IL-4 receptor: signaling mechanisms and biologic functions

8 July 2018

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On the role of PGD2 metabolites as markers of mast cell activation in asthma.

8 July 2018

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Genetic and biochemical evidence for a critical role of Janus kinase (JAK)-3 in mast cell-mediated type I hypersensitivity reactions

8 July 2018

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Inhibitory cytokines in asthma

8 July 2018

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8 July 2018

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The role of Jak3 in lymphoid development, activation, and signaling

8 July 2018

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Complexity and redundancy in the pathogenesis of asthma: reassessing the roles of mast cells and T cells

8 July 2018

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Immune regulation by CD40-CD40-L interactions

8 July 2018

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Expression of Janus kinase 3 in human endothelial and other non-lymphoid and non-myeloid cells

8 July 2018

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Mediator and cytokine mechanisms in asthma

8 July 2018

1 reference

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IFN-gamma represses epsilon germline transcription and subsequently down-regulates switch recombination to epsilon.

8 July 2018

1 reference

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Jaks and Stats in signaling by the cytokine receptor superfamily

8 July 2018

1 reference

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Expression of the CD40 ligand in T lymphocytes and induction of IgE isotype switching

8 July 2018

1 reference

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The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

8 July 2018

1 reference

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Interaction of bacteria with mast cells

8 July 2018

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Physicochemical properties of reaginic antibody. 1. Association of reaginic activity with an immunoglobulin other than gammaA- or gammaG-globulin.

8 July 2018

1 reference

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Cytokine production by mast cells and basophils

8 July 2018

1 reference

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Synthetic staurosporines via a ring closing metathesis strategy as potent JAK3 inhibitors and modulators of allergic responses.

8 July 2018

1 reference

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The JAK-3 inhibitor CP-690550 is a potent anti-inflammatory agent in a murine model of pulmonary eosinophilia

25 October 2018

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Anatomical location determines the distribution and function of dendritic cells and other APCs in the respiratory tract

25 October 2018

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Role of gender and hormone-related events on IgE, atopy, and eosinophils in the Epidemiological Study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy

25 October 2018

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Induction of inflammatory cell accumulation using human mast cell tryptases

25 October 2018

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Cytokines, signaling and diseases - a pharmacologist's view

25 October 2018

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Mechanisms associated with IL-6-induced up-regulation of Jak3 and its role in monocytic differentiation.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

Prevention of CD40-triggered dendritic cell maturation and induction of T-cell hyporeactivity by targeting of Janus kinase 3.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

Inflammatory cytokines can enhance CD44-mediated airway epithelial cell adhesion independently of CD44 expression

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

IGF-1 potentiation of IL-4-induced CD23/Fc(epsilon)RII expression in human B cells.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

IL-9 enhances the growth of human mast cell progenitors under stimulation with stem cell factor

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

Neuregulin-1 activates the JAK-STAT pathway and regulates lung epithelial cell proliferation.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

CD45 controls interleukin-4-mediated IgE class switch recombination in human B cells through its function as a Janus kinase phosphatase

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

Role of STAT6 in IgE receptor/FcepsilonRI-mediated late phase allergic responses of mast cells

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

The Po River Delta epidemiological survey: reference values of total serum IgE levels in a normal population sample of North Italy (8-78 yrs).

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

In vivo pharmacokinetics and anti-anaphylactic activity of the novel mast cell inhibitor 4-(4'-hydroxylphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131).

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

IL-4 inhibits mouse mast cell Fc epsilonRI expression through a STAT6-dependent mechanism.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

Acute Allergen-Induced Airway Remodeling in Atopic Asthma

25 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4311760

Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31(hi)Ly-6C(neg) bone marrow precursors in a mouse model of asthma

9 December 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Activation of the Janus kinase 3-STAT5a pathway after CD40 triggering of human monocytes but not of resting B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Role of common cytokine receptor gamma chain (gamma(c))- and Jak3-dependent signaling in the proliferation and survival of murine mast cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

A novel JAK3 mutation in a Japanese patient with severe combined immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Role of mast cell leukotrienes in neutrophil recruitment and bacterial clearance in infectious peritonitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Asthma: more than an inflammatory disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Deficiency of the tryptase-positive, chymase-negative mast cell type in gastrointestinal mucosa of patients with defective T lymphocyte function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

CD40 triggered human monocyte-derived dendritic cells convert to tolerogenic dendritic cells when JAK3 activity is inhibited

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Role of Janus kinase 3 in mast cell-mediated innate immunity against gram-negative bacteria

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Role of JAK3 in CD40-mediated signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Role of the CD40-CD40 ligand interaction in CD4+ T cell contact-dependent activation of monocyte interleukin-1 synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Inflammatory mediators of asthma: an update

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Intraepithelial dendritic cells and selective activation of Th2-like lymphocytes in patients with atopic asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Unusual interleukin-4 and -13 signaling in human normal and tumor lung fibroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Pathogenesis of asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Alteration of balance between myeloid dendritic cells and plasmacytoid dendritic cells in peripheral blood of patients with asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Relationships of active and passive smoking to total IgE in adults of the Epidemiological Study of the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy (EGEA)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

An epidemiological study on total and specific IgE levels in Japanese schoolchildren

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Production of chemokines and proinflammatory and antiinflammatory cytokines by human alveolar macrophages activated by IgE receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Mice deficient for the CD40 ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Treatment of allergic asthma by targeting janus kinase 3-dependent leukotriene synthesis in mast cells with 4-(3', 5'-dibromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline (WHI-P97)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

[Anti-IgE (Omalizumab): a hope in the treatment of allergic diseases]

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Mast cells are critical for the production of leukotrienes responsible for neutrophil recruitment in immune complex-induced peritonitis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Interactive effect of inhaled bradykinin with histamine and PGD2 in bronchial asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

The effects of an anti-CD4 monoclonal antibody, keliximab, on peripheral blood CD4+ T-cells in asthma

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Nonhematopoietic expression of Janus kinase 3 is required for efficient recruitment of Th2 lymphocytes and eosinophils in OVA-induced airway inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

Reversible translocation of 5-lipoxygenase in mast cells upon IgE/antigen stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/20430118

1 reference

12 December 2020

Human severe combined immunodeficiency: genetic, phenotypic, and functional diversity in one hundred eight infants

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

The Demise of Anti–IL-5 for Asthma, or Not

1 reference

https://pubmed.ncbi.nlm.nih.gov/20430118

12 December 2020

10.1016/J.INTIMP.2010.04.014

Identifiers

DOI

1 reference

5 August 2017

1 reference

5 August 2017

1 reference