Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry. (Q34975941)

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English	Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry.	scientific article

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2 November 2019

Analysis of the mechanism by which the small-molecule CCR5 antagonists SCH-351125 and SCH-350581 inhibit human immunodeficiency virus type 1 entry (English)

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2 November 2019

Alexandra Trkola

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2 November 2019

Thomas P Sakmar

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2 November 2019

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Fotini Tsamis

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2 November 2019

Svetlana Gavrilov

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2 November 2019

Francis Kajumo

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2 November 2019

Christoph Seibert

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2 November 2019

Shawn Kuhmann

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2 November 2019

Tom Ketas

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2 November 2019

Anadan Palani

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2 November 2019

John W Clader

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2 November 2019

Jayaram R Tagat

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2 November 2019

Stuart McCombie

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2 November 2019

Bahige Baroudy

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2 November 2019

John P Moore

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2 November 2019

Tatjana Dragic

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2 November 2019

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1 May 2003

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2 November 2019

Journal of Virology

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2 November 2019

77

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2 November 2019

9

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2 November 2019

5201-5208

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2 November 2019

New therapeutics that modulate chemokine networks

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8 July 2018

Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity

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8 July 2018

HIV-1 escape from a small molecule, CCR5-specific entry inhibitor does not involve CXCR4 use

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8 July 2018

SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo

1 reference

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8 July 2018

Piperazine-based CCR5 antagonists as HIV-1 inhibitors. II. Discovery of 1-[(2,4-dimethyl-3-pyridinyl)carbonyl]-4- methyl-4-[3(S)-methyl-4-[1(S)-[4-(trifluoromethyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailabl

1 reference

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8 July 2018

Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1'-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4'-methyl-1,4'- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection

1 reference

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Piperazine-based CCR5 antagonists as HIV-1 inhibitors. I: 2(S)-methyl piperazine as a key pharmacophore element

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An overview of the determinants of CCR5 and CXCR4 co-receptor function

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New targets for inhibitors of HIV-1 replication

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Mapping the determinants of the CCR5 amino-terminal sulfopeptide interaction with soluble human immunodeficiency virus type 1 gp120-CD4 complexes

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Global survey of genetic variation in CCR5, RANTES, and MIP-1alpha: impact on the epidemiology of the HIV-1 pandemic.

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HIV chemotherapy

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The effect of genetic variation in chemokines and their receptors on HIV transmission and progression to AIDS.

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A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5

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8 July 2018

Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease

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A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

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8 July 2018

Enhanced inhibition of human immunodeficiency virus type 1 by Met-stromal-derived factor 1beta correlates with down-modulation of CXCR4.

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Differential inhibition of human immunodeficiency virus type 1 fusion, gp120 binding, and CC-chemokine activity by monoclonal antibodies to CCR5

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CCR5-Mediated human immunodeficiency virus entry depends on an amino-terminal gp120-binding site and on the conformational integrity of all four extracellular domains

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New developments in anti-HIV chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12692222

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene

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https://pubmed.ncbi.nlm.nih.gov/12692222

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemokine receptors and HIV entry

1 reference

https://pubmed.ncbi.nlm.nih.gov/12692222

12 December 2020

based on heuristic

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Identifiers

10.1128/JVI.77.9.5201-5208.2003

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2 November 2019

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2 November 2019

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2 November 2019

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