Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner (Q34974825)

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English	Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

5 August 2017

Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner (English)

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Europe PubMed Central

PubMed publication ID

5 August 2017

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Anthony H. Futerman

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Anthony H Futerman

6

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Sujoy Lahiri

1

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Europe PubMed Central

PubMed publication ID

5 August 2017

Hyejung Park

2

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Europe PubMed Central

PubMed publication ID

5 August 2017

Elad L Laviad

3

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Europe PubMed Central

PubMed publication ID

5 August 2017

Xuequan Lu

4

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Europe PubMed Central

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5 August 2017

Robert Bittman

5

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Europe PubMed Central

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5 August 2017

language of work or name

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publication date

8 April 2009

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Europe PubMed Central

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5 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

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5 August 2017

284

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Europe PubMed Central

PubMed publication ID

5 August 2017

24

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Europe PubMed Central

PubMed publication ID

5 August 2017

16090-16098

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.

1 reference

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8 July 2018

FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells

1 reference

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Cyclical and dose-dependent responses of adult human mature oligodendrocytes to fingolimod.

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8 July 2018

Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720.

1 reference

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8 July 2018

Effects of phosphorylation of immunomodulatory agent FTY720 (fingolimod) on antiproliferative activity against breast and colon cancer cells

1 reference

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8 July 2018

Recent trials for FTY720 (fingolimod): a new generation of immunomodulators structurally similar to sphingosine

1 reference

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FTY720 (fingolimod) for relapsing multiple sclerosis.

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8 July 2018

Spisulosine (ES-285) induces prostate tumor PC-3 and LNCaP cell death by de novo synthesis of ceramide and PKCzeta activation.

1 reference

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8 July 2018

Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate

1 reference

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8 July 2018

Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine

1 reference

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8 July 2018

Fingolimod: a novel immunosuppressant for multiple sclerosis

1 reference

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8 July 2018

FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia

1 reference

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8 July 2018

FTY720: a most promising immunosuppressant modulating immune cell functions

1 reference

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8 July 2018

Sphingosine 1-phosphate receptor modulators: a new class of immunosuppressants.

1 reference

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8 July 2018

The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors

1 reference

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8 July 2018

LASS3 (longevity assurance homologue 3) is a mainly testis-specific (dihydro)ceramide synthase with relatively broad substrate specificity

1 reference

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8 July 2018

Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus

1 reference

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8 July 2018

LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor

1 reference

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8 July 2018

Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720

1 reference

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8 July 2018

Sphingolipidomics: high-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry

1 reference

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8 July 2018

Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas

1 reference

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8 July 2018

Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713526

8 July 2018

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1 reference

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8 July 2018

Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases

1 reference

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8 July 2018

Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.

1 reference

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8 July 2018

Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors

1 reference

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A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

1 reference

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Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells

1 reference

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8 July 2018

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

1 reference

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

1 reference

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8 July 2018

Marked prevention of tumor growth and metastasis by a novel immunosuppressive agent, FTY720, in mouse breast cancer models.

1 reference

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Assessment of agonism at G-protein coupled receptors by phosphatidic acid and lysophosphatidic acid in human embryonic kidney 293 cells

1 reference

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8 July 2018

The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2713526

8 July 2018

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.

1 reference

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21 January 2018

FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807438200

21 January 2018

The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807438200

21 January 2018

Fumonisins: fungal toxins that shed light on sphingolipid function

1 reference

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21 January 2018

Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M807438200

21 January 2018

Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry

1 reference

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26 October 2018

Immunosuppressant FTY720 inhibits thymocyte emigration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19357080

12 December 2020

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10.1074/JBC.M807438200

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

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