Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment (Q34857689)

4 August 2017

title

Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment (English)

1 reference

4 August 2017

0 references

5

Rafi Ahmed

1 reference

4 August 2017

3

Kaja Murali-Krishna

1 reference

4 August 2017

1

E John Wherry

1 reference

4 August 2017

Joseph N Blattman

2

1 reference

4 August 2017

Robbert van der Most

series ordinal

4

1 reference

4 August 2017

language of work or name

English

0 references

publication date

1 April 2003

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4 August 2017

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4 August 2017

volume

77

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4 August 2017

issue

8

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4 August 2017

page(s)

4911-4927

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Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma

4 August 2017

cites work

1 reference

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Activation-induced nonresponsiveness: a Th-dependent regulatory checkpoint in the CTL response

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The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes

8 July 2018

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Critical role for perforin-, Fas/FasL-, and TNFR1-mediated cytotoxic pathways in down-regulation of antigen-specific T cells during persistent viral infection

8 July 2018

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Residual viral replication during antiretroviral therapy boosts human immunodeficiency virus type 1-specific CD8+ T-cell responses in subjects treated early after infection

8 July 2018

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Dressed to kill? A review of why antiviral CD8 T lymphocytes fail to prevent progressive immunodeficiency in HIV-1 infection

8 July 2018

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Critical role for alpha/beta and gamma interferons in persistence of lymphocytic choriomeningitis virus by clonal exhaustion of cytotoxic T cells

8 July 2018

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Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus

8 July 2018

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8 July 2018

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In vivo selection of a lymphocytic choriomeningitis virus variant that affects recognition of the GP33-43 epitope by H-2Db but not H-2Kb

8 July 2018

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Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression

8 July 2018

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Preferential localization of effector memory cells in nonlymphoid tissue

8 July 2018

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Assessing CD8 T cell number and dysfunction in the presence of antigen

8 July 2018

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Simian immunodeficiency virus (SIV) infection of a rhesus macaque induces SIV-specific CD8(+) T cells with a defect in effector function that is reversible on extended interleukin-2 incubation

8 July 2018

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A permissive role for tumor necrosis factor in vascular endothelial growth factor-induced vascular permeability.

8 July 2018

1 reference

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Functional impairment of simian immunodeficiency virus-specific CD8+ T cells during the chronic phase of infection

8 July 2018

1 reference

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Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children

8 July 2018

1 reference

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Cutting edge: OFF cycling of TNF production by antigen-specific CD8+ T cells is antigen independent

8 July 2018

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Impaired function of circulating HIV-specific CD8(+) T cells in chronic human immunodeficiency virus infection.

8 July 2018

1 reference

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A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon

8 July 2018

1 reference

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The role of CD4(+) T helper cells in the cytotoxic T lymphocyte response to HIV-1.

8 July 2018

1 reference

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HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function

8 July 2018

1 reference

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The selective proteasome inhibitors lactacystin and epoxomicin can be used to either up- or down-regulate antigen presentation at nontoxic doses

8 July 2018

1 reference

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Dissecting the multifactorial causes of immunodominance in class I-restricted T cell responses to viruses.

8 July 2018

1 reference

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Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells

8 July 2018

1 reference

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Inverted immunodominance and impaired cytolytic function of CD8+ T cells during viral persistence in the central nervous system.

8 July 2018

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Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients

8 July 2018

1 reference

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Quantitative analysis of hepatitis C virus-specific CD8(+) T cells in peripheral blood and liver using peptide-MHC tetramers

8 July 2018

1 reference

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Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.

8 July 2018

1 reference

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Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes

8 July 2018

1 reference

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Distinct kinetics of cytokine production and cytolysis in effector and memory T cells after viral infection.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Viral immune evasion due to persistence of activated T cells without effector function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Longitudinal analysis of human immunodeficiency virus type 1-specific cytotoxic T lymphocyte responses: a predominant gag-specific response is associated with nonprogressive infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Direct visualization of antigen-specific T cells: HTLV-1 Tax11-19- specific CD8(+) T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Modifications of CD8+ T cell function during in vivo memory or tolerance induction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Differential presentation of the same MHC class I epitopes by fibroblasts and dendritic cells.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Identification of Db- and Kb-restricted subdominant cytotoxic T-cell responses in lymphocytic choriomeningitis virus-infected mice

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Kinetics of immune functions and virus replication during HIV-1 infection

8 July 2018

1 reference

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Uncovering subdominant cytotoxic T-lymphocyte responses in lymphocytic choriomeningitis virus-infected BALB/c mice.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Human cytotoxic T lymphocyte responses to Epstein-Barr virus infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Analysis of cytotoxic T cell responses to dominant and subdominant epitopes during acute and chronic lymphocytic choriomeningitis virus infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?

8 July 2018

1 reference

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Hepatitis B virus immunopathology

8 July 2018

1 reference

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Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome

8 July 2018

1 reference

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Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection

8 July 2018

1 reference

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CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Cytotoxic T cells and human herpes virus infections

8 July 2018

1 reference

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Bone marrow is a major site of long-term antibody production after acute viral infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression.

8 July 2018

1 reference

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Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Effective clearance of a persistent viral infection requires cooperation between virus-specific Lyt2+ T cells and nonspecific bone marrow-derived cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Organ-specific selection of viral variants during chronic infection

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Virus-lymphocyte interaction: T cells of the helper subset are infected with lymphocytic choriomeningitis virus during persistent infection in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Genetic basis of viral persistence: single amino acid change in the viral glycoprotein affects ability of lymphocytic choriomeningitis virus to persist in adult mice

8 July 2018

1 reference

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In vivo selection of lymphocyte-tropic and macrophage-tropic variants of lymphocytic choriomeningitis virus during persistent infection

8 July 2018

1 reference

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Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Reduced functional capacity of CD8+ T cells expanded by post-exposure vaccination of gamma-herpesvirus-infected CD4-deficient mice.

26 October 2018

1 reference

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Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Vaccine protection against functional CTL abnormalities in simian human immunodeficiency virus-infected rhesus monkeys.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

CD8 T cells specific for human immunodeficiency virus, Epstein-Barr virus, and cytomegalovirus lack molecules for homing to lymphoid sites of infection

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Dysfunctional Epstein-Barr virus (EBV)-specific CD8(+) T lymphocytes and increased EBV load in HIV-1 infected individuals progressing to AIDS-related non-Hodgkin lymphoma

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Visualizing the generation of memory CD4 T cells in the whole body

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Activated and memory CD8+ T cells can be distinguished by their cytokine profiles and phenotypic markers.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Persistence of memory CD8 T cells in MHC class I-deficient mice

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Forms and functions of CD44.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Accumulation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Circulating CD8 T lymphocytes in human immunodeficiency virus-infected individuals have impaired function and downmodulate CD3 zeta, the signaling chain of the T-cell receptor complex.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Eventual AIDS vaccine failure in a rhesus monkey by viral escape from cytotoxic T lymphocytes

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=152117

Immunogenicity of peptides bound to MHC class I molecules depends on the MHC-peptide complex stability

9 December 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/12663797

12 December 2020

Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/12663797

12 December 2020

The presence of high amounts of HBV-DNA in serum is associated with suppressed costimulatory effects of interleukin 12 on HBV-induced immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/12663797

12 December 2020

Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12663797

12 December 2020

High viral burden in the presence of major HIV-specific CD8(+) T cell expansions: evidence for impaired CTL effector function

1 reference

https://pubmed.ncbi.nlm.nih.gov/12663797

12 December 2020

Cutting edge: neosynthesis is required for the presentation of a T cell epitope from a long-lived viral protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/12663797

12 December 2020

10.1128/JVI.77.8.4911-4927.2003

Identifiers

DOI

1 reference

4 August 2017

1 reference

4 August 2017

1 reference