pRb-Independent growth arrest and transcriptional regulation of E2F target genes (Q34768305)

4 August 2017

title

pRb-Independent growth arrest and transcriptional regulation of E2F target genes (English)

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4 August 2017

Michael T McCabe

1

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4 August 2017

Odinaka J Azih

series ordinal

2

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4 August 2017

Mark L Day

series ordinal

3

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4 August 2017

language of work or name

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1 February 2005

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4 August 2017

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4 August 2017

volume

7

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4 August 2017

issue

2

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4 August 2017

page(s)

141-151

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Identification of target genes of the p16INK4A-pRB-E2F pathway.

4 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry

7 July 2018

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

7 July 2018

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E2F and cell cycle control: a double-edged sword

7 July 2018

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Unbiased analysis of RB-mediated transcriptional repression identifies novel targets and distinctions from E2F action.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Gene profiling of cell cycle progression through S-phase reveals sequential expression of genes required for DNA replication and nucleosome assembly

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Identification of novel E2F1-regulated genes by microarray

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Retinoblastoma protein partners

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

The retinoblastoma gene: a prototypic and multifunctional tumor suppressor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Sex hormone-induced carcinogenesis in Rb-deficient prostate tissue

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Combinatorial roles for pRB, p107, and p130 in E2F-mediated cell cycle control

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Neural precursor cells differentiating in the absence of Rb exhibit delayed terminal mitosis and deregulated E2F 1 and 3 activity.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Differential regulation of the retinoblastoma family of proteins during cell proliferation and differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

p107 is a suppressor of retinoblastoma development in pRb-deficient mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

E2F-6, a member of the E2F family that can behave as a transcriptional repressor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

The subcellular localization of E2F-4 is cell-cycle dependent

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Shared role of the pRB-related p130 and p107 proteins in limb development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Inhibition of apoptosis by the retinoblastoma gene product.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Marked alteration in phosphorylation of the RB protein during differentiation of human promyelocytic HL60 cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Failure of senescent cells to phosphorylate the RB protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Requirement for a functional Rb-1 gene in murine development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Effects of an Rb mutation in the mouse

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Transcriptional regulation and function during the human cell cycle

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1501127

Distinct gene expression phenotypes of cells lacking Rb and Rb family members

26 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/15802019

12 December 2020

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1 reference

https://pubmed.ncbi.nlm.nih.gov/15802019

12 December 2020

Increased retinoblastoma gene expression is associated with late stages of differentiation in many different cell types

1 reference

https://pubmed.ncbi.nlm.nih.gov/15802019

12 December 2020

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15802019

12 December 2020

Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/15802019

12 December 2020

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/15802019

12 December 2020

Effects of heterozygosity for the Rb-1t19neo allele in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/15802019

12 December 2020

Targeted disruption of p107: functional overlap between p107 and Rb

1 reference

https://pubmed.ncbi.nlm.nih.gov/15802019

12 December 2020

Cell anchorage regulates apoptosis through the retinoblastoma tumor suppressor/E2F pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15802019

12 December 2020

Identifiers

DOI

10.1593/NEO.04394

1 reference

4 August 2017

1 reference

4 August 2017

1 reference