Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha} (Q34694913)

4 August 2017

title

Converting IL-15 to a superagonist by binding to soluble IL-15R{alpha} (English)

1 reference

4 August 2017

5

Onur Boyman

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4 August 2017

7

Jonathan Sprent

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4 August 2017

6

Charles D Surh

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4 August 2017

Mark P Rubinstein

1

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4 August 2017

Marek Kovar

series ordinal

2

1 reference

4 August 2017

Jared F Purton

series ordinal

3

1 reference

4 August 2017

Jae-Ho Cho

series ordinal

4

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4 August 2017

language of work or name

English

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publication date

6 June 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

4 August 2017

published in

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4 August 2017

volume

103

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4 August 2017

issue

24

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4 August 2017

page(s)

9166-9171

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Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins

4 August 2017

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IL-15: targeting CD8+ T cells for immunotherapy

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Membrane-bound and soluble IL-15/IL-15Ralpha complexes display differential signaling and functions on human hematopoietic progenitors.

7 July 2018

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IL-15 and IL-15Ralpha in CD4+T cell immunity

7 July 2018

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The roles of interleukin-15 receptor alpha: trans-presentation, receptor component, or both?

7 July 2018

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Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.

7 July 2018

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Coordinate expression and trans presentation of interleukin (IL)-15Ralpha and IL-15 supports natural killer cell and memory CD8+ T cell homeostasis

7 July 2018

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Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist

7 July 2018

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Optimizing the binding affinity of a carrier protein: a case study on the interaction between soluble ifnar2 and interferon beta.

7 July 2018

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Transregulation of memory CD8 T-cell proliferation by IL-15Rα+ bone marrow–derived cells

7 July 2018

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IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory

7 July 2018

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IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells

7 July 2018

1 reference

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Systemic administration of IL-15 augments the antigen-specific primary CD8+ T cell response following vaccination with peptide-pulsed dendritic cells.

7 July 2018

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Interleukin 15 controls both proliferation and survival of a subset of memory-phenotype CD8(+) T cells

7 July 2018

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Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells

7 July 2018

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Overexpression of interleukin (IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells

7 July 2018

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The IL-2/IL-15 receptor systems: targets for immunotherapy

7 July 2018

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T cell-independent interleukin 15Ralpha signals are required for bystander proliferation

7 July 2018

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IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation

7 July 2018

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Interleukin 15: biology and relevance to human disease

7 July 2018

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Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

7 July 2018

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Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.

7 July 2018

1 reference

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Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology

7 July 2018

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T cell stimulation in vivo by lipopolysaccharide (LPS).

7 July 2018

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The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.

7 July 2018

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CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells.

7 July 2018

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Dendritic cell-derived IL-15 controls the induction of CD8 T cell immune responses

21 January 2018

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Blocking IL-15 prevents the induction of allergen-specific T cells and allergic inflammation in vivo

21 January 2018

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The Sushi domain of soluble IL-15 receptor alpha is essential for binding IL-15 and inhibiting inflammatory and allogenic responses in vitro and in vivo.

21 January 2018

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Natural soluble interleukin-15Ralpha is generated by cleavage that involves the tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17).

21 January 2018

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Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity.

21 January 2018

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Use of an antibody against the soluble interleukin 2 receptor alpha subunit can modulate the stability and biodistribution of interleukin-2

21 January 2018

1 reference

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12 December 2020

Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection

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https://pubmed.ncbi.nlm.nih.gov/16757567

12 December 2020

Modification of human leukocyte interferon pharmacology with a monoclonal antibody

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12 December 2020

Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes

1 reference

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12 December 2020

IL-7 transgenic mice: analysis of the role of IL-7 in the differentiation of thymocytes in vivo and in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16757567

12 December 2020

A point mutation in interleukin-2 that alters ligand internalization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16757567

12 December 2020

Soluble cytokine receptors as carrier proteins: effects of soluble interleukin-4 receptors on the pharmacokinetics of murine interleukin-4

1 reference

https://pubmed.ncbi.nlm.nih.gov/16757567

12 December 2020

IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16757567

12 December 2020

Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16757567

12 December 2020

The structure of the interleukin-15 alpha receptor and its implications for ligand binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/16757567

12 December 2020

Identifiers

DOI

10.1073/PNAS.0600240103

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4 August 2017

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4 August 2017

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