A membrane-embedded glutamate is required for ligand binding to the multidrug transporter EmrE (Q34661412)

3 August 2017

title

A membrane-embedded glutamate is required for ligand binding to the multidrug transporter EmrE (English)

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3 August 2017

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T R Muth

1

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3 August 2017

S Schuldiner

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 January 2000

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3 August 2017

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3 August 2017

volume

19

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3 August 2017

issue

2

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3 August 2017

page(s)

234-240

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Structural basis of multidrug recognition by BmrR, a transcription activator of a multidrug transporter

3 August 2017

cites work

1 reference

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A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA.

7 July 2018

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Characterization of Glu126 and Arg144, two residues that are indispensable for substrate binding in the lactose permease of Escherichia coli

7 July 2018

1 reference

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NMR investigation of the multidrug transporter EmrE, an integral membrane protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305557

EmrE, the smallest ion-coupled transporter, provides a unique paradigm for structure-function studies

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305557

Proton-dependent multidrug efflux systems

7 July 2018

1 reference

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Negative dominance studies demonstrate the oligomeric structure of EmrE, a multidrug antiporter from Escherichia coli.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305557

P-glycoprotein and multidrug resistance

7 July 2018

1 reference

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The SMR family: a novel family of multidrug efflux proteins involved with the efflux of lipophilic drugs.

7 July 2018

1 reference

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A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport

7 July 2018

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Prevention of drug access to bacterial targets: permeability barriers and active efflux

7 July 2018

1 reference

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Vesicular neurotransmitter transporters: from bacteria to humans

7 July 2018

1 reference

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A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes

7 July 2018

1 reference

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Energetics of reserpine binding and occlusion by the chromaffin granule biogenic amine transporter

7 July 2018

1 reference

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A simplification of the protein assay method of Lowry et al. which is more generally applicable

7 July 2018

1 reference

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An essential glutamyl residue in EmrE, a multidrug antiporter from Escherichia coli

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305557

Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter.

26 October 2018

1 reference

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Determining the secondary structure and orientation of EmrE, a multi-drug transporter, indicates a transmembrane four-helix bundle.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305557

Bacterial multidrug resistance is due to a single membrane protein which functions as a drug pump.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305557

Scanning Cysteine Accessibility of EmrE, an H+-coupled Multidrug Transporter fromEscherichia coli, Reveals a Hydrophobic Pathway for Solutes

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10637227

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

EmrE, an Escherichia coli 12-kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solvents

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/10637227

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/EMBOJ/19.2.234

1 reference

3 August 2017

1 reference

3 August 2017

1 reference