MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles. (Q34644199)

PubMed publication ID

23080337

3 August 2017

title

MicroRNA therapeutics for cardiovascular disease: opportunities and obstacles (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6813819&resulttype=core&format=json

12 May 2020

1 reference

cardiovascular disease

1 reference

Eva van Rooij

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6813819&resulttype=core&format=json

12 May 2020

Eric N Olson

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6813819&resulttype=core&format=json

12 May 2020

publication date

19 October 2012

1 reference

PubMed publication ID

23080337

Nature Reviews Drug Discovery

3 August 2017

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6813819&resulttype=core&format=json

12 May 2020

volume

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6813819&resulttype=core&format=json

12 May 2020

issue

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6813819&resulttype=core&format=json

12 May 2020

page(s)

860-872

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6813819&resulttype=core&format=json

A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure

12 May 2020

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MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice

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MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation

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A Role for miR-145 in Pulmonary Arterial Hypertension

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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

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Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

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The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis

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MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury

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Inhibition of miR-15 protects against cardiac ischemic injury

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microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects

31 March 2020

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MicroRNAs: target recognition and regulatory functions

31 March 2020

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MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation

31 March 2020

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MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

31 March 2020

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Mammalian microRNAs predominantly act to decrease target mRNA levels

31 March 2020

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A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?

31 March 2020

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Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

31 March 2020

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Most Caenorhabditis elegans microRNAs are individually not essential for development or viability

31 March 2020

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Analysis of microRNA knockouts in mice

31 March 2020

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MicroRNAs add a new dimension to cardiovascular disease

31 March 2020

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MicroRNA functions in stress responses.

31 March 2020

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Inhibition of microRNA function by antimiR oligonucleotides

31 March 2020

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Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model

31 March 2020

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Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2

31 March 2020

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Adeno-associated virus (AAV) serotype 9 provides global cardiac gene transfer superior to AAV1, AAV6, AAV7, and AAV8 in the mouse and rat.

31 March 2020

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Adenovirus-based vaccines generate cytotoxic T lymphocytes to epitopes of NS1 from dengue virus that are present in all major serotypes

31 March 2020

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Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection

31 March 2020

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MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship

31 March 2020

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Specificity, duplex degradation and subcellular localization of antagomirs

31 March 2020

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Silencing of microRNAs in vivo with 'antagomirs'

31 March 2020

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A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides

31 March 2020

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Developing microRNA therapeutics

31 March 2020

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miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting

31 March 2020

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Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

31 March 2020

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Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides.

31 March 2020

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Silencing of microRNA families by seed-targeting tiny LNAs

31 March 2020

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Silencing of microRNA-21 in vivo ameliorates autoimmune splenomegaly in lupus mice

31 March 2020

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Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice

31 March 2020

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Phosphorothioate oligonucleotides inhibit the intrinsic tenase complex by an allosteric mechanism

31 March 2020

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Complement activation is responsible for acute toxicities in rhesus monkeys treated with a phosphorothioate oligodeoxynucleotide

31 March 2020

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Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

31 March 2020

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Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

31 March 2020

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LNA-mediated microRNA silencing in non-human primates

31 March 2020

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Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure

31 March 2020

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miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1.

31 March 2020

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MicroRNAs can generate thresholds in target gene expression

31 March 2020

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Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA

31 March 2020

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The impact of microRNAs on protein output

31 March 2020

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Widespread changes in protein synthesis induced by microRNAs

31 March 2020

1 reference

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MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.

31 March 2020

1 reference

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Control of stress-dependent cardiac growth and gene expression by a microRNA

31 March 2020

1 reference

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A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance

31 March 2020

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A cardiac microRNA governs systemic energy homeostasis by regulation of MED13

31 March 2020

1 reference

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A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans

31 March 2020

1 reference

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Mediator MED23 links insulin signaling to the adipogenesis transcription cascade

31 March 2020

1 reference

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An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

31 March 2020

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Control of glucose homeostasis and insulin sensitivity by the Let-7 family of microRNAs

31 March 2020

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MicroRNAs 103 and 107 regulate insulin sensitivity

31 March 2020

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The Lin28/let-7 axis regulates glucose metabolism

31 March 2020

1 reference

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PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy.

31 March 2020

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miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis

31 March 2020

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Identification of a microRNA signature in renal fibrosis: role of miR-21.

31 March 2020

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Smad3-mediated upregulation of miR-21 promotes renal fibrosis

31 March 2020

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Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21.

31 March 2020

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Comparison of different miR-21 inhibitor chemistries in a cardiac disease model

31 March 2020

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MicroRNA-133 controls cardiac hypertrophy

31 March 2020

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microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart

31 March 2020

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Biogenesis of MiRNA-195 and its role in biogenesis, the cell cycle, and apoptosis

31 March 2020

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MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes

31 March 2020

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Transient regenerative potential of the neonatal mouse heart

31 March 2020

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Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium

31 March 2020

1 reference

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Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a

31 March 2020

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Integration of flow-dependent endothelial phenotypes by Kruppel-like factor 2

31 March 2020

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The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury

31 March 2020

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TGF-β/Smad3 signaling promotes renal fibrosis by inhibiting miR-29

31 March 2020

1 reference

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Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosis

31 March 2020

1 reference

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miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice.

31 March 2020

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Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

31 March 2020

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Suppression of hepatic stellate cell activation by microRNA-29b.

31 March 2020

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Protective role of estrogen-induced miRNA-29 expression in carbon tetrachloride-induced mouse liver injury

31 March 2020

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miR-29 is a major regulator of genes associated with pulmonary fibrosis.

31 March 2020

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MicroRNA-29, a key regulator of collagen expression in systemic sclerosis

31 March 2020

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Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

31 March 2020

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miR-29b participates in early aneurysm development in Marfan syndrome.

31 March 2020

1 reference

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Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report

31 March 2020

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Regulation of B- and T-cell differentiation by a single microRNA

31 March 2020

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miR-155 gene: a typical multifunctional microRNA.

31 March 2020

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miR-155: on the crosstalk between inflammation and cancer

31 March 2020

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The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding

31 March 2020

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Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes

31 March 2020

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Regulation of the germinal center response by microRNA-155

31 March 2020

1 reference

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MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis

31 March 2020

1 reference

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Cardiovascular importance of the microRNA-23/27/24 family

31 March 2020

1 reference

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Regulation of angiogenesis and choroidal neovascularization by members of microRNA-23~27~24 clusters

31 March 2020

1 reference

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MicroRNA-24 regulates vascularity after myocardial infarction

31 March 2020

1 reference

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miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes

31 March 2020

1 reference

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Acquisition of the contractile phenotype by murine arterial smooth muscle cells depends on the Mir143/145 gene cluster

31 March 2020

1 reference

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The knockout of miR-143 and -145 alters smooth muscle cell maintenance and vascular homeostasis in mice: correlates with human disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD3864

miR-33 links SREBP-2 induction to repression of sterol transporters

31 March 2020

1 reference

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MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD3864

MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD3864

MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD3864

Pharmacokinetics of phosphorothioate antisense oligodeoxynucleotides

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23080337

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The mechanism of naked DNA uptake and expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23080337

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRD3864

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6813819&resulttype=core&format=json

release_e4nwgkshfvhnlgb5ncpi3litw4

12 May 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/e4nwgkshfvhnlgb5ncpi3litw4

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6813819&resulttype=core&format=json

12 May 2020

PubMed publication ID

23080337

1 reference