Mechanisms for T cell receptor triggering (Q34625569)

3 August 2017

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title

Mechanisms for T cell receptor triggering (English)

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3 August 2017

2

Omer Dushek

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Philip Anton van der Merwe

3 August 2017

series ordinal

1

object named as

P Anton van der Merwe

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3 August 2017

publication date

3 December 2010

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Nature Reviews Immunology

3 August 2017

published in

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3 August 2017

volume

11

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3 August 2017

issue

1

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3 August 2017

page(s)

47-55

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Induction of tyrosine phosphorylation and T-cell activation by vanadate peroxide, an inhibitor of protein tyrosine phosphatases

3 August 2017

cites work

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https://api.crossref.org/works/10.1038%2FNRI2887

Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI2887

Lipid raft proteins have a random distribution during localized activation of the T-cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Signal transduction by lymphocyte antigen receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

T cell receptor engagement by peptide-MHC ligands induces a conformational change in the CD3 complex of thymocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

T cell receptor engagement triggers its CD3epsilon and CD3zeta subunits to adopt a compact, locked conformation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Direct observation of ligand recognition by T cells.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

T cell killing does not require the formation of a stable mature immunological synapse.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Modeling T cell antigen discrimination based on feedback control of digital ERK responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Cooperative enhancement of specificity in a lattice of T cell receptors

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Positive and negative selection of T cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

The molecular basis of TCR germline bias for MHC is surprisingly simple

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Evolutionarily conserved amino acids that control TCR-MHC interaction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

How TCRs bind MHCs, peptides, and coreceptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Molecular mechanisms involved in T cell receptor triggering

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Kinetic proofreading in T-cell receptor signal transduction

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Kinetic discrimination in T-cell activation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

A mechanism for SRC kinase-dependent signaling by noncatalytic receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Initiation of TCR signalling revisited

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

A role for "self" in T-cell activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Ligand-specific oligomerization of T-cell receptor molecules

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Evidence for a functional sidedness to the alphabetaTCR.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

DySCo: quantitating associations of membrane proteins using two-color single-molecule tracking.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Single-molecule level analysis of the subunit composition of the T cell receptor on live T cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Taking T cells beyond the diffraction limit

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

A structural basis for the selection of dominant alphabeta T cell receptors in antiviral immunity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

The T cell receptor: critical role of the membrane environment in receptor assembly and function

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Deconstructing the form and function of the TCR/CD3 complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Distinctive CD3 heterodimeric ectodomain topologies maximize antigen-triggered activation of alpha beta T cell receptors

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Tonic ubiquitylation controls T-cell receptor:CD3 complex expression during T-cell development

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

The cytoplasmic tail of the T cell receptor CD3 epsilon subunit contains a phospholipid-binding motif that regulates T cell functions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

The safety on the TCR trigger

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

What controls T cell receptor phosphorylation?

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Response multilayered control of T cell receptor phosphorylation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

The receptor deformation model of TCR triggering

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Immunology: how do T cells recognize antigen?

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

Cutting Edge: mechanical forces acting on T cells immobilized via the TCR complex can trigger TCR signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

The TCR triggering puzzle

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Surface-anchored monomeric agonist pMHCs alone trigger TCR with high sensitivity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Peptide-major histocompatibility complex dimensions control proximal kinase-phosphatase balance during T cell activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

The alphabeta T cell receptor is an anisotropic mechanosensor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

A new trigger for T cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI2887

The organizing principle in the formation of the T cell receptor-CD3 complex.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

The constant region of the membrane immunoglobulin mediates B cell-receptor clustering and signaling in response to membrane antigens.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Constitutively active Lck kinase in T cells drives antigen receptor signal transduction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

The structure and ligand interactions of CD2: implications for T-cell function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Lipid rafts and their roles in T-cell activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

The kinetic-segregation model: TCR triggering and beyond

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

The tyrosine phosphatase CD148 is excluded from the immunologic synapse and down-regulates prolonged T cell signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Lipid rafts: elusive or illusive?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Lipid rafts as a membrane-organizing principle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Condensation of the plasma membrane at the site of T lymphocyte activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Plasma membrane rafts engaged in T cell signalling: new developments in an old concept

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

T-cell receptor microclusters critical for T-cell activation are formed independently of lipid raft clustering

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Lipid rafts and T cell receptor signaling: a critical re-evaluation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Memory in receptor-ligand-mediated cell adhesion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI2887

Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon

31 March 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/21127503

12 December 2020

Accessory cell independent proliferation of human T4 cells stimulated by immobilized monoclonal antibodies to CD3

1 reference

https://pubmed.ncbi.nlm.nih.gov/21127503

12 December 2020

A conformation-induced oligomerization model for B cell receptor microclustering and signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/21127503

12 December 2020

Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21127503

12 December 2020

Identifiers

DOI

10.1038/NRI2887

1 reference

Dimensions Publication ID

3 August 2017

1048706629

0 references

1 reference