The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target (Q34607601)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17263143%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

review article

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title

The hepatitis C virus NS3 protein: a model RNA helicase and potential drug target (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17263143%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

1 reference

1 reference

David N Frick

1

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24 December 2019

publication date

1 January 2007

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Current Issues in Molecular Biology

24 December 2019

published in

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24 December 2019

volume

9

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24 December 2019

issue

1

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24 December 2019

page(s)

1-20

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RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP

24 December 2019

cites work

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Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase

7 July 2018

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Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus

7 July 2018

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Complete replication of hepatitis C virus in cell culture

7 July 2018

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Robust hepatitis C virus infection in vitro

7 July 2018

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Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro

7 July 2018

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Electrostatic analysis of the hepatitis C virus NS3 helicase reveals both active and allosteric site locations

7 July 2018

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Inhibition of Hepatitis C Virus Nonstructural Protein, Helicase Activity, and Viral Replication by a Recombinant Human Antibody Clone

7 July 2018

1 reference

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Structure of adeno-associated virus type 2 Rep40-ADP complex: insight into nucleotide recognition and catalysis by superfamily 3 helicases

7 July 2018

1 reference

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Enhanced nucleic acid binding to ATP-bound hepatitis C virus NS3 helicase at low pH activates RNA unwinding

7 July 2018

1 reference

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Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus

7 July 2018

1 reference

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WebLogo: A Sequence Logo Generator

7 July 2018

1 reference

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Synthesis and evaluation of ATP-binding site directed potential inhibitors of nucleoside triphosphatases/helicases and polymerases of hepatitis C and other selected Flaviviridae viruses.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

The arginine finger of bacteriophage T7 gene 4 helicase: role in energy coupling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Hepatitis C virus NS3 RNA helicase activity is modulated by the two domains of NS3 and NS4A.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Double-stranded DNA-induced localized unfolding of HCV NS3 helicase subdomain 2.

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently

7 July 2018

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High-resolution structure of the E.coli RecQ helicase catalytic core

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Abrogation of hepatitis C virus NS3 helicase enzymatic activity by recombinant human antibodies

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

DExD/H-box proteins and their partners: helping RNA helicases unwind

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Defining the ATPase center of bacteriophage T4 DNA packaging machine: requirement for a catalytic glutamate residue in the large terminase protein gp17.

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Inhibition of HCV NS3 protease by RNA aptamers in cells

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Hepatitis C Virus NS3 ATPases/Helicases from Different Genotypes Exhibit Variations in Enzymatic Properties

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

MolMovDB: analysis and visualization of conformational change and structural flexibility

7 July 2018

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Structurally conserved amino Acid w501 is required for RNA helicase activity but is not essential for DNA helicase activity of hepatitis C virus NS3 protein.

7 July 2018

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NTPase/helicase of Flaviviridae: inhibitors and inhibition of the enzyme.

7 July 2018

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Nucleotide triphosphatase/helicase of hepatitis C virus as a target for antiviral therapy

7 July 2018

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Hepatitis C virus NS3 ATPase/helicase: an ATP switch regulates the cooperativity among the different substrate binding sites

7 July 2018

1 reference

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Functional neutralization of HIV-1 Vif protein by intracellular immunization inhibits reverse transcription and viral replication

7 July 2018

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New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease

7 July 2018

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Cloning and molecular characterization of human high affinity antibody fragments against Hepatitis C virus NS3 helicase

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding

7 July 2018

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Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Hepatitis C virus NS3 and simian virus 40 T antigen helicases displace streptavidin from 5'-biotinylated oligonucleotides but not from 3'-biotinylated oligonucleotides: evidence for directional bias in translocation on single-stranded DNA.

7 July 2018

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Structural analysis of DNA replication fork reversal by RecG

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Electrostatics of nanosystems: application to microtubules and the ribosome

7 July 2018

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Structure-Based Mutational Analysis of the Hepatitis C Virus NS3 Helicase

7 July 2018

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The arginine-1493 residue in QRRGRTGR1493G motif IV of the hepatitis C virus NS3 helicase domain is essential for NS3 protein methylation by the protein arginine methyltransferase 1.

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Biological evaluation of hepatitis C virus helicase inhibitors

7 July 2018

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Enhancement of hepatitis C virus RNA replication by cell culture-adaptive mutations

7 July 2018

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Specific Interaction of Hepatitis C Virus Protease/Helicase NS3 with the 3'-Terminal Sequences of Viral Positive- and Negative-Strand RNA

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Unwinding of nucleic acids by HCV NS3 helicase is sensitive to the structure of the duplex

7 July 2018

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Mutations That Affect Dimer Formation and Helicase Activity of the Hepatitis C Virus Helicase

7 July 2018

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The RNA aptamer-binding site of hepatitis C virus NS3 protease

7 July 2018

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Efficient initiation of HCV RNA replication in cell culture

7 July 2018

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Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase

7 July 2018

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Roles of the AX(4)GKS and arginine-rich motifs of hepatitis C virus RNA helicase in ATP- and viral RNA-binding activity

7 July 2018

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Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides

7 July 2018

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A genomic approach of the hepatitis C virus generates a protein interaction map.

7 July 2018

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Subcellular localization, stability, and trans-cleavage competence of the hepatitis C virus NS3-NS4A complex expressed in tetracycline-regulated cell lines

7 July 2018

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Characterization of a monoclonal antibody and its single-chain antibody fragment recognizing the nucleoside Triphosphatase/Helicase domain of the hepatitis C virus nonstructural 3 protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Helicase motifs: the engine that powers DNA unwinding

7 July 2018

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Structure and function of hepatitis C virus NS3 helicase

7 July 2018

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Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase

7 July 2018

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Crystal structure of the helicase domain from the replicative helicase-primase of bacteriophage T7

7 July 2018

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Subcellular localisation of NS3 in HCV-infected hepatocytes.

7 July 2018

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The linker region between the helicase and primase domains of the bacteriophage T7 gene 4 protein is critical for hexamer formation

7 July 2018

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Structure-based mutagenesis study of hepatitis C virus NS3 helicase

7 July 2018

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DNA binding mediates conformational changes and metal ion coordination in the active site of PcrA helicase

7 July 2018

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A novel recombinant single-chain hepatitis C virus ns3-ns4a protein with improved helicase activity

7 July 2018

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Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism

7 July 2018

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Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein

7 July 2018

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Product release is the major contributor to kcat for the hepatitis C virus helicase-catalyzed strand separation of short duplex DNA.

7 July 2018

1 reference

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Multiple enzymatic activities associated with recombinant NS3 protein of hepatitis C virus

7 July 2018

1 reference

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Human and murine antibody recognition is focused on the ATPase/helicase, but not the protease domain of the hepatitis C virus nonstructural 3 protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Crystal structure of RNA helicase from genotype 1b hepatitis C virus. A feasible mechanism of unwinding duplex RNA

7 July 2018

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A kinetic analysis of the oligonucleotide-modulated ATPase activity of the helicase domain of the NS3 protein from hepatitis C virus. The first cycle of interaction of ATP with the enzyme is unique

7 July 2018

1 reference

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Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo.

7 July 2018

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Serine protease of hepatitis C virus expressed in insect cells as the NS3/4A complex.

7 July 2018

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Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding

7 July 2018

1 reference

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Mutational analysis of the hepatitis C virus RNA helicase

7 July 2018

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Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

7 July 2018

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Major Domain Swiveling Revealed by the Crystal Structures of Complexes of E. coli Rep Helicase Bound to Single-Stranded DNA and ADP

7 July 2018

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Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee

7 July 2018

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A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Structure of the hepatitis C virus RNA helicase domain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Thermodynamics and kinetics of a Brownian motor

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

AlF3 mimics the transition state of protein phosphorylation in the crystal structure of nucleoside diphosphate kinase and MgADP

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Crystal structure of a DExx box DNA helicase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Mechanisms of helicase-catalyzed DNA unwinding

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

A steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Hepatitis C virus NS3 protein polynucleotide-stimulated nucleoside triphosphatase and comparison with the related pestivirus and flavivirus enzymes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

A Domain of the Gene 4 Helicase/Primase of Bacteriophage T7 Required for the Formation of an Active Hexamer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Significance of the immune response to a major, conformational B-cell epitope on the hepatitis C virus NS3 region defined by a human monoclonal antibody

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Sequence logos: a new way to display consensus sequences

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Structure of the recA protein–ADP complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Rational design of dual-functional aptamers that inhibit the protease and helicase activities of HCV NS3.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

A Brownian motor mechanism of translocation and strand separation by hepatitis C virus helicase

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

An RNA ligand inhibits hepatitis C virus NS3 protease and helicase activities

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Hepatitis C NS3 helicase unwinds RNA in leaps and bounds

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

In vitro selection of RNA aptamers against the HCV NS3 helicase domain

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Periodic cycles of RNA unwinding and pausing by hepatitis C virus NS3 helicase

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

The functional interaction of the hepatitis C virus helicase molecules is responsible for unwinding processivity

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

The conserved glutamate residue adjacent to the Walker-B motif is the catalytic base for ATP hydrolysis in the ATP-binding cassette transporter BmrA.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

ATP binding modulates the nucleic acid affinity of hepatitis C virus helicase

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Identification of a key determinant of hepatitis C virus cell culture adaptation in domain II of NS3 helicase

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Construction and characterization of an intracellular single-chain human antibody to hepatitis C virus non-structural 3 protein

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Modulation of the hepatitis C virus RNA-dependent RNA polymerase activity by the non-structural (NS) 3 helicase and the NS4B membrane protein.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Helicase from hepatitis C virus, energetics of DNA binding

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Inhibition of the helicase activity of HCV NTPase/helicase by 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide-5 '-triphosphate (ribavirin-TP).

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Hepatitis C virus NS3 NTPase/helicase: different stereoselectivity in nucleoside triphosphate utilisation suggests that NTPase and helicase activities are coupled by a nucleotide-dependent rate limiting step

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Mutational analysis of hepatitis C virus NS3-associated helicase

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Isolation and characterization of RNA aptamers specific for the hepatitis C virus nonstructural protein 3 protease

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Kinetic analysis of the effects of mutagenesis of W501 and V432 of the hepatitis C virus NS3 helicase domain on ATPase and strand-separating activity

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Probing the relationship between RNA-stimulated ATPase and helicase activities of HCV NS3 using 2'-O-methyl RNA substrates

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

The helicase from hepatitis C virus is active as an oligomer

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Functional interactions between conserved motifs of the hepatitis C virus RNA helicase protein NS3.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Hepatitis C virus: an infectious molecular clone of a second major genotype (2a) and lack of viability of intertypic 1a and 2a chimeras

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Inhibition of the hepatitis C virus helicase-associated ATPase activity by the combination of ADP, NaF, MgCl2, and poly(rU). Two ADP binding sites on the enzyme-nucleic acid complex

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Towards defining a minimal functional domain for NTPase and RNA helicase activities of the hepatitis C virus NS3 protein.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Expression, isolation, and characterization of the hepatitis C virus ATPase/RNA helicase

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3571657

Importance of F1-ATPase residue alpha-Arg-376 for catalytic transition state stabilization

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17263143

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Allosteric effects of nucleotide cofactors on Escherichia coli Rep helicase-DNA binding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17263143

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Biochemical analysis of mutant T7 primase/helicase proteins defective in DNA binding, nucleotide hydrolysis, and the coupling of hydrolysis with DNA unwinding

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17263143

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17263143%20AND%20SRC:MED&resulttype=core&format=json

24 December 2019

PubMed publication ID

17263143

1 reference