IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6 (Q34521302)

2 August 2017

title

IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6 (English)

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2 August 2017

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David Yen

1

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2 August 2017

Jeanne Cheung

2

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2 August 2017

Heleen Scheerens

3

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2 August 2017

Frédérique Poulet

4

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2 August 2017

Terrill McClanahan

5

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2 August 2017

Brent McKenzie

6

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2 August 2017

Melanie A Kleinschek

7

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2 August 2017

Alex Owyang

8

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2 August 2017

Jeanine Mattson

9

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2 August 2017

Wendy Blumenschein

10

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2 August 2017

Erin Murphy

11

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2 August 2017

Manjiri Sathe

12

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2 August 2017

Daniel J Cua

13

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2 August 2017

Robert A Kastelein

14

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2 August 2017

Donna Rennick

15

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2 August 2017

language of work or name

English

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publication date

1 May 2006

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Journal of Clinical Investigation

2 August 2017

published in

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2 August 2017

volume

116

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2 August 2017

issue

5

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2 August 2017

page(s)

1310-1316

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IL-23 drives a pathogenic T cell population that induces autoimmune inflammation

2 August 2017

cites work

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Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation

7 July 2018

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Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

7 July 2018

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

7 July 2018

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Increased expression of interleukin 17 in inflammatory bowel disease

7 July 2018

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Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17

7 July 2018

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A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R

7 July 2018

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

7 July 2018

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7 July 2018

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Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway

7 July 2018

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IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis

7 July 2018

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Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways

7 July 2018

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Anti-IL-12 antibody prevents the development and progression of collagen-induced arthritis in IFN-gamma receptor-deficient mice

7 July 2018

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7 July 2018

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T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

7 July 2018

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Proinflammatory and immunoregulatory functions of interleukin-12.

7 July 2018

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Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses

7 July 2018

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T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

7 July 2018

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Immunopathogenesis of chronic inflammatory bowel disease.

7 July 2018

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Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

7 July 2018

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Antibodies to interleukin 12 abrogate established experimental colitis in mice

7 July 2018

1 reference

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Human IL-17: a novel cytokine derived from T cells

7 July 2018

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IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts

7 July 2018

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Microbial lipopeptides induce the production of IL-17 in Th cells.

27 October 2018

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Selective engraftment of memory CD4+ T cells with an unusual recirculation pattern and a diverse T cell receptor-V beta repertoire into scid mice.

27 October 2018

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Blockade of interleukin 6 trans signaling suppresses T-cell resistanceagainst apoptosis in chronic intestinal inflammation: Evidence in Crohn diseaseand experimental colitis in vivo

27 October 2018

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Dual role of IL-12 in early and late stages of murine collagen type II arthritis

9 December 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

Blockade of IL-12 during the induction of collagen-induced arthritis (CIA) markedly attenuates the severity of the arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

IL-6 is required for the development of Th1 cell-mediated murine colitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

Antigen-induced IL-17 response in the peripheral blood mononuclear cells (PBMC) of healthy controls

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

IL-17 stimulates intraperitoneal neutrophil infiltration through the release of GRO alpha chemokine from mesothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

IL-12, but not IFN-gamma, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

A Phase I Study Evaluating the Safety, Pharmacokinetics, and Clinical Response of a Human IL-12 p40 Antibody in Subjects with Plaque Psoriasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

Anti-IL-6 receptor monoclonal antibody inhibits leukocyte recruitment and promotes T-cell apoptosis in a murine model of Crohn's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

Evidence for continuous stimulation of interleukin-6 production in Crohn's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16670770

12 December 2020

Identifiers

DOI

10.1172/JCI21404

1 reference

2 August 2017

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2 August 2017

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