Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials (Q34429383)

2 August 2017

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title

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials (English)

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2 August 2017

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E S Newlands

1

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2 August 2017

M F Stevens

2

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2 August 2017

S R Wedge

3

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2 August 2017

R T Wheelhouse

4

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2 August 2017

C Brock

5

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2 August 2017

publication date

1 January 1997

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2 August 2017

published in

Cancer Treatment Reviews

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2 August 2017

volume

23

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2 August 2017

issue

1

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2 August 2017

page(s)

35-61

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From triazines and triazenes to temozolomide

2 August 2017

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Antitumor imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one , a novel broad-spectrum antitumor agent

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Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)

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Antitumor imidazotetrazines. 14. Synthesis and antitumor activity of 6- and 8-substituted imidazo[5,1-d]-1,2,3,5-tetrazinones and 8-substituted pyrazolo[5,1-d]-1,2,3,5-tetrazinones

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Pharmacokinetics of the 13C labeled anticancer agent temozolomide detected in vivo by selective cross-polarization transfer

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Antitumor imidazotetrazines. 20. Preparation of the 8-acid derivative of mitozolomide and its utility in the preparation of active antitumor agents

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NMR and molecular modeling investigation of the mechanism of activation of the antitumor drug temozolomide and its interaction with DNA.

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Characterisation of urinary metabolites of temozolomide in humans and mice and evaluation of their cytotoxicity

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Antitumor imidazotetrazines. 25. Crystal structure of 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (temozolomide) and structural comparisons with the related drugs mitozolomide and DTIC.

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Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide.

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Antitumor imidazotetrazines--XV. Role of guanine O6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones

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Depletion of O6-alkylguanine-DNA alkyltransferase correlates with potentiation of temozolomide and CCNU toxicity in human tumour cells

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Potentiation of temozolomide and BCNU cytotoxicity by O(6)-benzylguanine: a comparative study in vitro

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Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea

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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

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Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

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GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells

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Extension of the pre-DNA synthetic phase of the cell cycle as a consequence of DNA alkylation in Chinese hamster cells: A possible mechanism of DNA repair

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O6-methylguanine in DNA inhibits replication in vitro by human cell extracts

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Clues to the pathogenesis of familial colorectal cancer

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Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

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3-aminobenzamide and/or O6-benzylguanine evaluated as an adjuvant to temozolomide or BCNU treatment in cell lines of variable mismatch repair status and O6-alkylguanine-DNA alkyltransferase activity

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Reconstitution of the DNA base excision-repair pathway

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Possible roles of beta-elimination and delta-elimination reactions in the repair of DNA containing AP (apurinic/apyrimidinic) sites in mammalian cells

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7 January 2021

3T3 NIH murine fibroblasts and B78 murine melanoma cells expressing the Escherichia coli N3-methyladenine-DNA glycosylase I do not become resistant to alkylating agents

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Antitumour imidazotetrazines XXVIII 3-methyladenine DNA glycosylase activity in cell lines sensitive and resistant to temozolomide

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Antitumour imidazotetrazines--XI: Effect of 8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one [CCRG 81045; M and B 39831 NSC 362856] on poly(ADP-ribose) metabolism

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Induction of haemoglobin synthesis in the human leukaemia cell line K562 by monomethyltriazenes and imidazotetrazinones

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Antitumour imidazotetrazines--XVIII. Modification of the level of 5-methylcytosine in DNA by 3-substituted imidazotetrazinones

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Inhibition of cellular esterases by the antitumour imidazotetrazines mitozolomide and temozolomide: demonstration by flow cytometry and conventional spectrofluorimetry.

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7 January 2021

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7 January 2021

O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.

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7 January 2021

Differential inactivation of mammalian and Escherichia coli O6-alkylguanine-DNA alkyltransferases by O6-benzylguanine

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7 January 2021

Temozolomide reduces the metastatic potential of lewis lung carcinoma (3LL) in mice: Role of α-6 integrin phosphorylation

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7 January 2021

A phase II study of mitozolomide in metastatic transitional cell carcinoma of the bladder

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7 January 2021

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7 January 2021

Mitozolomide in advanced renal cancer. A phase II study in previously untreated patients from the EORTC Genito-Urinary Tract Cancer Cooperative Group

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7 January 2021

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A registration and interpolation procedure for subvoxel matching of serially acquired MR images.

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7 January 2021

10.1016/S0305-7372(97)90019-0

Identifiers

DOI

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2 August 2017

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