A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. (Q34406066)

PubMed publication ID

15788759

2 August 2017

title

A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model (English)

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12 May 2020

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2

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12 May 2020

Sally A Frautschy

8

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12 May 2020

author name string

Giselle P Lim

1

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12 May 2020

Takashi Morihara

3

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12 May 2020

Fusheng Yang

4

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12 May 2020

Bruce Teter

5

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12 May 2020

Oliver Ubeda

6

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12 May 2020

Norman Salem

7

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12 May 2020

Greg M Cole

9

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12 May 2020

language of work or name

English

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publication date

1 March 2005

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PubMed publication ID

15788759

2 August 2017

published in

Journal of Neuroscience

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12 May 2020

volume

25

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12 May 2020

issue

12

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12 May 2020

page(s)

3032-3040

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

12 May 2020

cites work

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https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia.

1 reference

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12 December 2020

High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation

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12 December 2020

Inflammation and Alzheimer's disease

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https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.

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https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration.

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https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain

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12 December 2020

Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.

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12 December 2020

Chronic administration of docosahexaenoic acid improves the performance of radial arm maze task in aged rats

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https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Reversal of docosahexaenoic acid deficiency in the rat brain, retina, liver, and serum

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https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Reversibility of n-3 fatty acid deficiency-induced alterations of learning behavior in the rat: level of n-6 fatty acids as another critical factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Mechanisms of action of docosahexaenoic acid in the nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

N-3 polyunsaturated fatty acids prevent the defect of insulin receptor signaling in muscle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Prevalence of dementia in the older Japanese-Brazilian population

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https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer's disease model rats.

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https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Antioxidant strategies for Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Protective effects of docosahexaenoic acid in staurosporine-induced apoptosis: involvement of phosphatidylinositol-3 kinase pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Lipid peroxidation in aging brain and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

The significance of environmental factors in the etiology of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Oxidative stress increases expression and activity of BACE in NT2 neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Retinal sensitivity loss in third-generation n-3 PUFA-deficient rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Fish, meat, and risk of dementia: cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Omega-3 fatty acids in inflammation and autoimmune diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Cognitive deficits in docosahexaenoic acid-deficient rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Docosahexaenoic acid suppresses nitric oxide production and inducible nitric oxide synthase expression in interferon-gamma plus lipopolysaccharide-stimulated murine macrophages by inhibiting the oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Polyunsaturated docosahexaenoic vs docosapentaenoic acid-differences in lipid matrix properties from the loss of one double bond

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Docosapentaenoic acid does not completely replace DHA in n-3 FA-deficient rats during early development

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Recovery of brain docosahexaenoate leads to recovery of spatial task performance

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Beta-secretase activity increases with aging in human, monkey, and mouse brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Dietary intake of fatty acids and fish in relation to cognitive performance at middle age.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Reduced G protein-coupled signaling efficiency in retinal rod outer segments in response to n-3 fatty acid deficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Cholesterol efflux as a critical component of Alzheimer's disease pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Beta-amyloid precursor protein cleavage by a membrane-bound protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Dietary effects on brain fatty acid composition: the reversibility of n-3 fatty acid deficiency and turnover of docosahexaenoic acid in the brain, erythrocytes, and plasma of rhesus monkeys.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Brain cell and tissue recovery in rats made deficient in n-3 fatty acids by alteration of dietary fat

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Recovery of altered fatty acid composition induced by a diet devoid of n-3 fatty acids in myelin, synaptosomes, mitochondria, and microsomes of developing rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

The nervous system has an absolute molecular species requirement for proper function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Differences in the fatty acid composition of the grey and white matter of different regions of the brains of patients with Alzheimer's disease and control subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Arachidonic and docosahexaenoic acids are biosynthesized from their 18-carbon precursors in human infants

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Losses of arachidonic acid in rat liver after alcohol inhalation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Anti-inflammatory properties of docosahexaenoic and eicosapentaenoic acids in phorbol-ester-induced mouse ear inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Dietary fat intake and the risk of incident dementia in the Rotterdam Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Regional membrane phospholipid alterations in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Effect of the long-term feeding of dietary lipids on the learning ability, fatty acid composition of brain stem phospholipids and synaptic membrane fluidity in adult mice: a comparison of sardine oil diet with palm oil diet

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

Why is docosahexaenoic acid essential for nervous system function?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15788759

12 December 2020

10.1523/JNEUROSCI.4225-04.2005

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725084&resulttype=core&format=json

12 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6725084&resulttype=core&format=json

12 May 2020

PubMed publication ID

15788759

1 reference