Mechanisms of insulin resistance in obesity (Q34331776)

1 August 2017

title

Mechanisms of insulin resistance in obesity (English)

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1 August 2017

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Jianping Ye

1

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1 August 2017

publication date

9 March 2013

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1 August 2017

published in

Frontiers of medicine

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1 August 2017

volume

7

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1 August 2017

issue

1

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1 August 2017

page(s)

14-24

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Mitochondrial inhibitor as a new class of insulin sensitizer

1 August 2017

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Skeletal muscle "mitochondrial deficiency" does not mediate insulin resistance

6 July 2018

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6 July 2018

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S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2

6 July 2018

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6 July 2018

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Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity

6 July 2018

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6 July 2018

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6 July 2018

Angiogenesis and obesity

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6 July 2018

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6 July 2018

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6 July 2018

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Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

6 July 2018

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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

6 July 2018

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Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid-induced insulin resistance

6 July 2018

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Role of insulin in the pathogenesis of free fatty acid-induced insulin resistance in skeletal muscle

6 July 2018

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Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

6 July 2018

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Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity

6 July 2018

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

6 July 2018

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Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells

6 July 2018

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

6 July 2018

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Inflammation and insulin resistance

6 July 2018

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Reactive oxygen species have a causal role in multiple forms of insulin resistance

6 July 2018

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6 July 2018

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Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

6 July 2018

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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

6 July 2018

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6 July 2018

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6 July 2018

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Free fatty acids and insulin secretion in humans

6 July 2018

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

6 July 2018

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IKK-beta links inflammation to obesity-induced insulin resistance

6 July 2018

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Mitochondrial dysfunction and type 2 diabetes

6 July 2018

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ER stress and the unfolded protein response

6 July 2018

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Increased oxidative stress in obesity and its impact on metabolic syndrome

6 July 2018

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Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus

6 July 2018

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6 July 2018

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Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes

6 July 2018

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Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes

6 July 2018

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Adipose tissue as an endocrine organ

6 July 2018

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Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes

6 July 2018

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Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase

6 July 2018

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Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein

6 July 2018

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Insulin clearance in obesity

6 July 2018

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Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

6 July 2018

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Obesity is associated with macrophage accumulation in adipose tissue

6 July 2018

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Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts

6 July 2018

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Mitochondrial dysfunction in the elderly: possible role in insulin resistance

6 July 2018

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Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo

6 July 2018

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Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade

6 July 2018

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The many faces of macrophage activation

6 July 2018

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Alternative activation of macrophages

6 July 2018

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Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?

6 July 2018

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A central role for JNK in obesity and insulin resistance

6 July 2018

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Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters.

6 July 2018

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Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex.

6 July 2018

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Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process?

6 July 2018

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IRS proteins and the common path to diabetes

6 July 2018

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Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory

6 July 2018

1 reference

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Diet, lifestyle, and the risk of type 2 diabetes mellitus in women

6 July 2018

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Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

6 July 2018

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Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration

6 July 2018

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Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

6 July 2018

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Free fatty acids and pathogenesis of type 2 diabetes mellitus

6 July 2018

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Cellular mechanisms of insulin resistance

6 July 2018

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Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

6 July 2018

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

6 July 2018

1 reference

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

Oxidative stress and glycemic regulation.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

Reactive oxygen species are critical in the oleic acid-mediated mitogenic signaling pathway in vascular smooth muscle cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

TNF alpha-mediated inhibition and reversal of adipocyte differentiation is accompanied by suppressed expression of PPARgamma without effects on Pref-1 expression

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

Mechanism of free fatty acid-induced insulin resistance in humans

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

Ceramide signalling and the immune response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

Effects of fat on insulin-stimulated carbohydrate metabolism in normal men

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

Interleukin-6-deficient mice develop mature-onset obesity

6 July 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Exclusive action of transmembrane TNF alpha in adipose tissue leads to reduced adipose mass and local but not systemic insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Expression of CD68 and macrophage chemoattractant protein-1 genes in human adipose and muscle tissues: association with cytokine expression, insulin resistance, and reduction by pioglitazone

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Angiogenic role of LYVE-1-positive macrophages in adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Constitutive activation of IKKβ in adipose tissue prevents diet-induced obesity in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Gene expression profile in skeletal muscle of type 2 diabetes and the effect of insulin treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Asian Indians have enhanced skeletal muscle mitochondrial capacity to produce ATP in association with severe insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Palmitate, but not unsaturated fatty acids, induces the expression of interleukin-6 in human myotubes through proteasome-dependent activation of nuclear factor-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Stressed out about obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Endoplasmic reticulum stress plays a central role in development of leptin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Obstructive sleep apnea is independently associated with insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11684-013-0262-6

A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3936017

IL-6, a key cytokine in liver regeneration

27 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/23471659

12 December 2020

Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels

1 reference

https://pubmed.ncbi.nlm.nih.gov/23471659

12 December 2020

Combined Interleukin-6 and Interleukin-1 Deficiency Causes Obesity in Young Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23471659

12 December 2020

Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23471659

12 December 2020

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/23471659

12 December 2020

The adipocyte as an endocrine cell

1 reference

https://pubmed.ncbi.nlm.nih.gov/23471659

12 December 2020

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/23471659

12 December 2020

10.1007/S11684-013-0262-6

Identifiers

DOI

1 reference

Dimensions Publication ID

1 August 2017

1026797655

0 references

Fatcat ID

release_uoch5a4u2ffb3ebmkwszaoz6bm

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/uoch5a4u2ffb3ebmkwszaoz6bm

24 November 2022

mapped directly with Wikidata item

PMC publication ID

3936017

1 reference

1 August 2017

1 reference