The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice (Q34286263)

1 August 2017

title

The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice (English)

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1 August 2017

12

Douglas R Cavener

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1 August 2017

Peichuan Zhang

1

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1 August 2017

Barbara C McGrath

2

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1 August 2017

Jamie Reinert

3

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1 August 2017

DeAnne S Olsen

4

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1 August 2017

Li Lei

5

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1 August 2017

Sangeeta Gill

6

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1 August 2017

Sheree A Wek

7

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1 August 2017

Krishna M Vattem

8

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1 August 2017

Ronald C Wek

9

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1 August 2017

Scot R Kimball

10

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1 August 2017

Leonard S Jefferson

11

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1 August 2017

language of work or name

English

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publication date

1 October 2002

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Molecular and Cellular Biology

1 August 2017

published in

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1 August 2017

volume

22

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1 August 2017

issue

19

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1 August 2017

page(s)

6681-6688

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The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas

1 August 2017

cites work

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6 July 2018

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Tight binding of the phosphorylated alpha subunit of initiation factor 2 (eIF2alpha) to the regulatory subunits of guanine nucleotide exchange factor eIF2B is required for inhibition of translation initiation

6 July 2018

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Translational control is required for the unfolded protein response and in vivo glucose homeostasis

6 July 2018

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Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

6 July 2018

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The tRNA-binding moiety in GCN2 contains a dimerization domain that interacts with the kinase domain and is required for tRNA binding and kinase activation

6 July 2018

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Regulated translation initiation controls stress-induced gene expression in mammalian cells

6 July 2018

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Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domain

6 July 2018

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Association of GCN1-GCN20 regulatory complex with the N-terminus of eIF2alpha kinase GCN2 is required for GCN2 activation

6 July 2018

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Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

6 July 2018

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A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha

6 July 2018

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Amino acid-induced stimulation of translation initiation in rat skeletal muscle

6 July 2018

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Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase

6 July 2018

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cpc-3, the Neurospora crassa homologue of yeast GCN2, encodes a polypeptide with juxtaposed eIF2alpha kinase and histidyl-tRNA synthetase-related domains required for general amino acid control

6 July 2018

1 reference

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Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase

6 July 2018

1 reference

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Cloning and characterization of a cDNA encoding a protein synthesis initiation factor-2alpha (eIF-2alpha) kinase from Drosophila melanogaster. Homology To yeast GCN2 protein kinase

6 July 2018

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Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2.

6 July 2018

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Role of translation initiation factor eIF-2B in the regulation of protein synthesis in mammalian cells

6 July 2018

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Amino acid-regulated gene expression in eukaryotic cells

6 July 2018

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Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA

6 July 2018

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eIF-2 kinases: regulators of general and gene-specific translation initiation

6 July 2018

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The histidyl-tRNA synthetase-related sequence in the eIF-2 alpha protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids

6 July 2018

1 reference

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Attenuation in the control of expression of bacterial operons

6 July 2018

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Regulation of Amino Acid Metabolism

6 July 2018

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Effects of Hypophysectomy on Amino Acid Metabolism and Gluconeogenesis in the Perfused Rat Liver

6 July 2018

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Purification and characterization of eukaryotic initiation factor 2 and a guanine nucleotide exchange factor from rat liver

6 July 2018

1 reference

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Prediction of brain and serum free amino acid profiles in rats fed graded levels of protein

6 July 2018

1 reference

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Multiple upstream AUG codons mediate translational control of GCN4.

6 July 2018

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Adaptation of rats to diets containing different levels of protein: effects on food intake, plasma and brain amino acid concentrations and brain neurotransmitter metabolism

6 July 2018

1 reference

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Sequences that surround the stop codons of upstream open reading frames in GCN4 mRNA determine their distinct functions in translational control

6 July 2018

1 reference

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Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134046

Transcriptional and translational regulation of gene expression in the general control of amino-acid biosynthesis in Saccharomyces cerevisiae.

6 July 2018

1 reference

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Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134046

Effect of different protein diets on the distribution of amino acids in plasma, liver and brain in the rat

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134046

Hepatic metabolism of genetically diabetic (db/db) mice. I. Carbohydrate metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134046

Initiation of protein synthesis in a cell-free system prepared from rat hepatocytes.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134046

GI Domain-mediated Association of the Eukaryotic Initiation Factor 2α Kinase GCN2 with Its Activator GCN1 Is Required for General Amino Acid Control in Budding Yeast

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=134046

The role of amino acids in the regulation of protein synthesis in perfused rat liver. II. Effects of amino acid deficiency on peptide chain initiation, polysomal aggregation, and distribution of albumin mRNA

9 December 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/12215525

12 December 2020

Mechanism of inhibition of peptide chain initiation by amino acid deprivation in perfused rat liver. Regulation involving inhibition of eukaryotic initiation factor 2 alpha phosphatase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12215525

12 December 2020

Purification and characterization of eukaryotic translational initiation factor eIF-2B from liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/12215525

12 December 2020

Positive and negative regulatory mechanisms that mediate long-term memory storage

1 reference

https://pubmed.ncbi.nlm.nih.gov/12215525

12 December 2020

Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/12215525

12 December 2020

Amino acid regulation of gene expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/12215525

12 December 2020

10.1128/MCB.22.19.6681-6688.2002

Identifiers

DOI

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1 August 2017

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1 August 2017

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