Molecular properties of the PTH/PTHrP receptor (Q34276973)

1 August 2017

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title

Molecular properties of the PTH/PTHrP receptor (English)

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1 August 2017

Gardella TJ

1

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1 August 2017

Jüppner H

series ordinal

2

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1 August 2017

publication date

1 July 2001

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Trends in Endocrinology and Metabolism

1 August 2017

published in

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1 August 2017

volume

12

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1 August 2017

issue

5

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1 August 2017

page(s)

210-217

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Physiology and pathophysiology of the extracellular calcium-sensing receptor

1 August 2017

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Genetic ablation of parathyroid glands reveals another source of parathyroid hormone

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PTHrP(1-36) as a skeletal anabolic agent for the treatment of osteoporosis

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Studies of the N-terminal region of a parathyroid hormone-related peptide (1-36) analog: receptor subtype-selective agonists, antagonists, and photochemical cross-linking agents

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Photoaffinity cross-linking identifies differences in the interactions of an agonist and an antagonist with the parathyroid hormone/parathyroid hormone-related protein receptor

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Small bone-building fragments of parathyroid hormone: new therapeutic agents for osteoporosis

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The (1-14) fragment of parathyroid hormone (PTH) activates intact and amino-terminally truncated PTH-1 receptors

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7 January 2021

Minimization of parathyroid hormone. Novel amino-terminal parathyroid hormone fragments with enhanced potency in activating the type-1 parathyroid hormone receptor

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7 January 2021

Further definition of the protein kinase C activation domain of the parathyroid hormone

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7 January 2021

Structurally diverse N-terminal peptides of parathyroid hormone (PTH) and PTH-related peptide (PTHRP) inhibit the Na+/H+ exchanger NHE3 isoform by binding to the PTH/PTHRP receptor type I and activating distinct signaling pathways

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7 January 2021

Amino-terminal modifications of human parathyroid hormone (PTH) selectively alter phospholipase C signaling via the type 1 PTH receptor: implications for design of signal-specific PTH ligands

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7 January 2021

Stimulation of protein kinase C activity in cells expressing human parathyroid hormone receptors by C- and N-terminally truncated fragments of parathyroid hormone 1-34

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7 January 2021

Lactam formation increases receptor binding, adenylyl cyclase stimulation and bone growth stimulation by human parathyroid hormone (hPTH)(1-28)NH2.

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7 January 2021

Non-homologous sequences of parathyroid hormone and the parathyroid hormone related peptide bind to a common receptor on ROS 17/2.8 cells

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7 January 2021

The bovine renal parathyroid hormone (PTH) receptor has equal affinity for two different amino acid sequences: the receptor binding domains of PTH and PTH-related protein are located within the 14-34 region

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7 January 2021

Formation of water-soluble complex between the 1-34 fragment of parathyroid hormone and dimyristoylphosphatidylcholine.

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7 January 2021

Structural elements of human parathyroid hormone and their possible relation to biological activities

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7 January 2021

Membrane lipid phase as catalyst for peptide-receptor interactions

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7 January 2021

Molecular characterization of the receptor-ligand complex for parathyroid hormone.

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7 January 2021

Evidence for a ligand interaction site at the amino-terminus of the parathyroid hormone (PTH)/PTH-related protein receptor from cross-linking and mutational studies

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7 January 2021

Stabilized NMR structure of human parathyroid hormone(1-34).

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7 January 2021

Addressing the Tertiary Structure of Human Parathyroid Hormone-(1–34)

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7 January 2021

Structure of human parathyroid hormone 1-37 in solution

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7 January 2021

Solution structure of the osteogenic 1-31 fragment of the human parathyroid hormone

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7 January 2021

Parathyroid hormone (PTH)-PTH-related peptide hybrid peptides reveal functional interactions between the 1-14 and 15-34 domains of the ligand

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7 January 2021

Solution structure of parathyroid hormone related protein (residues 1-34) containing an Ala substituted for an Ile in position 15 (PTHrP[Ala15]-(1-34))

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7 January 2021

Solution structures of human parathyroid hormone fragments hPTH(1-34) and hPTH(1-39) and bovine parathyroid hormone fragment bPTH(1-37)

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7 January 2021

Conformation of a peptide ligand bound to its G-protein coupled receptor

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7 January 2021

Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor

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7 January 2021

TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus

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7 January 2021

The PTH2 receptor and TIP39: a new peptide-receptor system

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7 January 2021

A G protein-coupled receptor from zebrafish is activated by human parathyroid hormone and not by human or teleost parathyroid hormone-related peptide. Implications for the evolutionary conservation of calcium-regulating peptide hormones

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7 January 2021

Zebrafish express the common parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R) and a novel receptor (PTH3R) that is preferentially activated by mammalian and fugufish parathyroid hormone-related peptide

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7 January 2021

Evaluating the Ligand Specificity of Zebrafish Parathyroid Hormone (PTH) Receptors: Comparison of PTH, PTH-Related Protein, and Tuberoinfundibular Peptide of 39 Residues

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7 January 2021

The Sequence of the Human Genome

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7 January 2021

The N-terminal fragment of human parathyroid hormone receptor 1 constitutes a hormone binding domain and reveals a distinct disulfide pattern

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7 January 2021

Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction

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7 January 2021

Arginine 186 in the extracellular N-terminal region of the human parathyroid hormone 1 receptor is essential for contact with position 13 of the hormone

1 reference

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7 January 2021

The hydrophobic residues phenylalanine 184 and leucine 187 in the type-1 parathyroid hormone (PTH) receptor functionally interact with the amino-terminal portion of PTH-(1-34)

1 reference

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7 January 2021

A Homozygous Inactivating Mutation in the Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor Causing Blomstrand Chondrodysplasia

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7 January 2021

Determinants of [Arg2]PTH-(1-34) binding and signaling in the transmembrane region of the parathyroid hormone receptor

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7 January 2021

Homolog-scanning mutagenesis of the parathyroid hormone (PTH) receptor reveals PTH-(1-34) binding determinants in the third extracellular loop

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7 January 2021

Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies

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7 January 2021

Converting parathyroid hormone-related peptide (PTHrP) into a potent PTH-2 receptor agonist

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7 January 2021

Transmembrane residues together with the amino terminus limit the response of the parathyroid hormone (PTH) 2 receptor to PTH-related peptide

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7 January 2021

Residues in the membrane-spanning and extracellular loop regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptide

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7 January 2021

Mutations of neighboring polar residues on the second transmembrane helix disrupt signaling by the parathyroid hormone receptor

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7 January 2021

Transmembrane residues of the parathyroid hormone (PTH)/PTH-related peptide receptor that specifically affect binding and signaling by agonist ligands

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7 January 2021

Autoactivation of type-1 parathyroid hormone receptors containing a tethered ligand

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7 January 2021

Constitutive activation of tethered-peptide/corticotropin-releasing factor receptor chimeras

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7 January 2021

Chimeric human calcitonin and glucagon receptors reveal two dissociable calcitonin interaction sites

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7 January 2021

Evaluating the signal transduction mechanism of the parathyroid hormone 1 receptor. Effect of receptor-G-protein interaction on the ligand binding mechanism and receptor conformation

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7 January 2021

G protein-coupled receptors. I. Diversity of receptor-ligand interactions

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7 January 2021

Mapping the bimolecular interface of the parathyroid hormone (PTH)-PTH1 receptor complex: spatial proximity between Lys(27) (of the hormone principal binding domain) and leu(261) (of the first extracellular loop) of the human PTH1 receptor

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7 January 2021

Characterization of parathyroid hormone/receptor interactions: structure of the first extracellular loop

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7 January 2021

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

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7 January 2021

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7 January 2021

The N-terminal region of the third intracellular loop of the parathyroid hormone (PTH)/PTH-related peptide receptor is critical for coupling to cAMP and inositol phosphate/Ca2+ signal transduction pathways

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7 January 2021

Mutations in the second cytoplasmic loop of the rat parathyroid hormone (PTH)/PTH-related protein receptor result in selective loss of PTH-stimulated phospholipase C activity

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7 January 2021

The PTH/PTHrP receptor in Jansen's metaphyseal chondrodysplasia.

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7 January 2021

Inverse agonism of amino-terminally truncated parathyroid hormone (PTH) and PTH-related peptide (PTHrP) analogs revealed with constitutively active mutant PTH/PTHrP receptors

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7 January 2021

Rapid desensitization of parathyroid hormone dependent adenylate cyclase in perifused human osteosarcoma cells (SaOS-2).

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7 January 2021

Mechanisms of desensitization to parathyroid hormone in human osteoblast-like SaOS-2 cells

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7 January 2021

Identification of phosphorylation sites in the G protein-coupled receptor for parathyroid hormone. Receptor phosphorylation is not required for agonist-induced internalization

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7 January 2021

Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves beta-arrestin2. Real-time monitoring by fluorescence microscopy

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7 January 2021

Role of signal transduction in internalization of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein

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7 January 2021

G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization

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7 January 2021

Phosphorylation of the cytoplasmic tail of the PTH/PTHrP receptor

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7 January 2021

Agonist-dependent phosphorylation of the parathyroid hormone/parathyroid hormone-related peptide receptor

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7 January 2021

Agonist-stimulated phosphorylation of the G protein-coupled receptor for parathyroid hormone (PTH) and PTH-related protein

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7 January 2021

Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases

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7 January 2021

The cytoplasmic tail of the G-protein-coupled receptor for parathyroid hormone and parathyroid hormone-related protein contains positive and negative signals for endocytosis

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7 January 2021

Cellular distribution of constitutively active mutant parathyroid hormone (PTH)/PTH-related protein receptors and regulation of cyclic adenosine 3',5'-monophosphate signaling by beta-arrestin2.

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7 January 2021

Selective and nonselective inverse agonists for constitutively active type-1 parathyroid hormone receptors: evidence for altered receptor conformations

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7 January 2021

Transmembrane helices predicted at 95% accuracy

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7 January 2021

10.1016/S1043-2760(01)00409-X

Identifiers

DOI

1 reference

1 August 2017

1 reference