Identification of the third Na+ site and the sequence of extracellular binding events in the glutamate transporter (Q34099018)

31 July 2017

title

Identification of the third Na+ site and the sequence of extracellular binding events in the glutamate transporter (English)

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31 July 2017

2

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31 July 2017

Zhijian Huang

1

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31 July 2017

language of work or name

English

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publication date

1 September 2010

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31 July 2017

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31 July 2017

volume

99

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31 July 2017

issue

5

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31 July 2017

page(s)

1416-1425

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Mechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.

31 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Transport mechanism of a bacterial homologue of glutamate transporters.

5 July 2018

1 reference

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Functional characterization of a Na+-dependent aspartate transporter from Pyrococcus horikoshii.

5 July 2018

1 reference

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Interactions of alkali cations with glutamate transporters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Time-resolved mechanism of extracellular gate opening and substrate binding in a glutamate transporter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Dynamics of the extracellular gate and ion-substrate coupling in the glutamate transporter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Very fast prediction and rationalization of pKa values for protein-ligand complexes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Transport direction determines the kinetics of substrate transport by the glutamate transporter EAAC1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Two conformational changes are associated with glutamate translocation by the glutamate transporter EAAC1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

The glutamate transporter subtypes EAAT4 and EAATs 1-3 transport glutamate with dramatically different kinetics and voltage dependence but share a common uptake mechanism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Very fast empirical prediction and rationalization of protein pKa values

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each other

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Structure of a glutamate transporter homologue from Pyrococcus horikoshii

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Fluorometric measurements of conformational changes in glutamate transporters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Comparison of coupled and uncoupled currents during glutamate uptake by GLT-1 transporters.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Early intermediates in the transport cycle of the neuronal excitatory amino acid carrier EAAC1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Flux coupling in a neuronal glutamate transporter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Predicting Ca(2+)-binding sites in proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Counterflow of L-glutamate in plasma membrane vesicles and reconstituted preparations from rat brain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Structural Aspects of Metal Liganding to Functional Groups in Proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Na(+):aspartate coupling stoichiometry in the glutamate transporter homologue Glt(Ph).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Voltage-independent sodium-binding events reported by the 4B-4C loop in the human glutamate transporter excitatory amino acid transporter 3.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Coupled, but not uncoupled, fluxes in a neuronal glutamate transporter can be activated by lithium ions

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Fast removal of synaptic glutamate by postsynaptic transporters

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Anion currents and predicted glutamate flux through a neuronal glutamate transporter.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Cysteine scanning of the surroundings of an alkali-ion binding site of the glutamate transporter GLT-1 reveals a conformationally sensitive residue

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Electrogenic properties of the epithelial and neuronal high affinity glutamate transporter

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Ion fluxes associated with excitatory amino acid transport.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2931724

Arginine 447 plays a pivotal role in substrate interactions in a neuronal glutamate transporter

28 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20816053

12 December 2020

Multiple consequences of mutating two conserved beta-bridge forming residues in the translocation cycle of a neuronal glutamate transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/20816053

12 December 2020

Anion conductance behavior of the glutamate uptake carrier in salamander retinal glial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20816053

12 December 2020

Mutation of an amino acid residue influencing potassium coupling in the glutamate transporter GLT-1 induces obligate exchange

1 reference

https://pubmed.ncbi.nlm.nih.gov/20816053

12 December 2020

10.1016/J.BPJ.2010.06.052

Identifiers

DOI

1 reference

release_p6akt4ciwva7rdc45vzy5gc4mu

31 July 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/p6akt4ciwva7rdc45vzy5gc4mu

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2931724

1 reference

31 July 2017

1 reference