Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases (Q34020244)

30 July 2017

title

Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases (English)

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amyotrophic lateral sclerosis

30 July 2017

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2

Deborah C Mash

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30 July 2017

Walter G Bradley

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30 July 2017

publication date

1 January 2009

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Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders

30 July 2017

published in

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30 July 2017

volume

10 Suppl 2

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30 July 2017

page(s)

7-20

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Amyotrophic lateral sclerosis: Part 1. Clinical features, pathology, and ethical issues in management

30 July 2017

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21 January 2018

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21 January 2018

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Lathyrism: evidence for role of the neuroexcitatory aminoacid BOAA.

21 January 2018

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21 January 2018

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Specific antagonism of excitotoxic action of 'uncommon' amino acids assayed in organotypic mouse cortical cultures

21 January 2018

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Stereospecific acute neuronotoxicity of 'uncommon' plant amino acids linked to human motor-system diseases

21 January 2018

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Slow toxins, biologic markers, and long-latency neurodegenerative disease in the western Pacific region

21 January 2018

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21 January 2018

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21 January 2018

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2-Amino-3-(methylamino)-propanoic acid (BMAA) in cycad flour: an unlikely cause of amyotrophic lateral sclerosis and parkinsonism-dementia of Guam.

21 January 2018

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Facilitated transport of the neurotoxin, beta-N-methylamino-L-alanine, across the blood-brain barrier

21 January 2018

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beta-Methylamino-L-alanine (BMAA) and amyotrophic lateral sclerosis-parkinsonism dementia of the western Pacific

21 January 2018

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Was a neurovirulent influenza virus the cause of amyotrophic lateral sclerosis and parkinsonism-dementia on Guam?

21 January 2018

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Amyotrophic lateral sclerosis and parkinsonism-dementia on Guam, 1945-1972. I. Descriptive epidemiology

21 January 2018

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Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam

21 January 2018

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Cycad neurotoxins, consumption of flying foxes, and ALS-PDC disease in Guam

21 January 2018

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Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam

21 January 2018

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Biomagnification of cycad neurotoxins in flying foxes: implications for ALS-PDC in Guam

21 January 2018

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Occurrence of beta-methylamino-l-alanine (BMAA) in ALS/PDC patients from Guam

21 January 2018

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A mechanism for slow release of biomagnified cyanobacterial neurotoxins and neurodegenerative disease in Guam

21 January 2018

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Neurotoxic flying foxes as dietary items for the Chamorro people, Marianas Islands

21 January 2018

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Production of the neurotoxin BMAA by a marine cyanobacterium

21 January 2018

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BMAA selectively injures motor neurons via AMPA/kainate receptor activation

21 January 2018

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Misincorporation of amino acid analogues into proteins by biosynthesis.

21 January 2018

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Retention of the cyanobacterial neurotoxin beta-N-methylamino-l-alanine in melanin and neuromelanin-containing cells--a possible link between Parkinson-dementia complex and pigmentary retinopathy

21 January 2018

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Selective brain uptake and behavioral effects of the cyanobacterial toxin BMAA (beta-N-methylamino-L-alanine) following neonatal administration to rodents

21 January 2018

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Diverse taxa of cyanobacteria produce β-N-methylamino-l-alanine, a neurotoxic amino acid

21 January 2018

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Phylogenetic and morphological diversity of cyanobacteria in soil desert crusts from the Colorado plateau.

21 January 2018

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The distribution of cyanobacteria across physical and chemical gradients in hot springs in northern Thailand

21 January 2018

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Endolithic microbial ecosystems

21 January 2018

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21 January 2018

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Cyanobacteria (Nostoc commune) used as a dietary item in the Peruvian highlands produce the neurotoxic amino acid BMAA.

21 January 2018

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Co-occurrence of beta-N-methylamino-L-alanine, a neurotoxic amino acid with other cyanobacterial toxins in British waterbodies, 1990-2004.

21 January 2018

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Amyotrophic lateral sclerosis and parkinsonism-dementia complex of Guam: changing incidence rates during the past 60 years

21 January 2018

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Prevalence of dementia in Chamorros on Guam: relationship to age, gender, education, and APOE.

21 January 2018

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Conservation Implications of Chamorro Consumption of Flying Foxes as a Possible Cause of Amyotrophic Lateral Sclerosis-Parkinsonism Dementia Complex in Guam

21 January 2018

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Worsening of neurologic syndrome in patients with Wilson's disease with initial penicillamine therapy

21 January 2018

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Zinc sulphate therapy for Wilson's disease after acute deterioration during treatment with low-dose D-penicillamine

21 January 2018

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Fatal deterioration of Wilson's disease after institution of oral zinc therapy.

21 January 2018

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Heredopathia atactica polyneuritiformis (refsum's disease) treated by diet and plasma-exchange

21 January 2018

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Plasma exchange in the treatment of Refsum's disease (heredopathia atactica polyneuritiformis)

21 January 2018

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Atypical parkinsonism of Japan: amyotrophic lateral sclerosis-parkinsonism-dementia complex of the Kii peninsula of Japan (Muro disease): an update

21 January 2018

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Return of the cycad hypothesis - does the amyotrophic lateral sclerosis/parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health?

21 January 2018

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Neurodegenerative disease. Guam's deadly stalker: on the loose worldwide?

21 January 2018

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Is there a role for naturally occurring cyanobacterial toxins in neurodegeneration? The beta-N-methylamino-L-alanine (BMAA) paradigm

21 January 2018

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Animal models of BMAA neurotoxicity: a critical review

21 January 2018

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Glutamate neurotoxicity and diseases of the nervous system

21 January 2018

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Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS.

21 January 2018

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Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

21 January 2018

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SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter

21 January 2018

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Effect of branched-chain amino acids on glutamate metabolism in amyotrophic lateral sclerosis.

21 January 2018

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Bicarbonate dependence of glutamate receptor activation by beta-N-methylamino-L-alanine: channel recording and study with related compounds

21 January 2018

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Neurotoxicity of beta-N-methylamino-L-alanine (BMAA) and beta-N-oxalylamino-L-alanine (BOAA) on cultured cortical neurons

21 January 2018

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Effects of L-beta-N-methylamino-L-alanine (L-BMAA) on the cortical cholinergic and glutamatergic systems of the rat.

21 January 2018

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The cycad neurotoxic amino acid, beta-N-methylamino-L-alanine (BMAA), elevates intracellular calcium levels in dissociated rat brain cells

21 January 2018

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Beta-methylamino-alanine (BMAA) injures hippocampal neurons in vivo

21 January 2018

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Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin

21 January 2018

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L-[3H]glutamate labels the metabotropic excitatory amino acid receptor in rodent brain

21 January 2018

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Interaction between beta-N-methylamino-L-alanine and excitatory amino acid receptors in brain slices and neuronal cultures.

21 January 2018

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Billion-fold difference in the toxic potencies of two excitatory plant amino acids, L-BOAA and L-BMAA: biochemical and morphological studies using mouse brain slices

21 January 2018

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Constitutive expression and functional characterization of mitochondrial glutaredoxin (Grx2) in mouse and human brain

21 January 2018

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Knockdown of cytosolic glutaredoxin 1 leads to loss of mitochondrial membrane potential: implication in neurodegenerative diseases

21 January 2018

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Beta-N-methylamino-L-alanine enhances neurotoxicity through multiple mechanisms

21 January 2018

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Cyanobacterial poisoning in livestock, wild mammals and birds--an overview

21 January 2018

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Beta-N-methylaminoalanine (BMAA): metabolism and metabolic effects in model systems and in neural and other tissues of the rat in vitro

21 January 2018

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Improving derivatization efficiency of BMAA utilizing AccQ-Tag in a complex cyanobacterial matrix

21 January 2018

1 reference

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Lack of beta-methylamino-l-alanine in brain from controls, AD, or Chamorros with PDC.

21 January 2018

1 reference

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Beta-methylamino-L-alanine analysis by liquid chromatography tandem mass spectrometry with iTRAQ as the derivative.

21 January 2018

1 reference

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Effective determination method for a cyanobacterial neurotoxin, beta-N-methylamino-L-alanine

21 January 2018

1 reference

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1H NMR determination of beta-N-methylamino-L-alanine (L-BMAA) in environmental and biological samples

21 January 2018

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Lack of cerebral bmaa in human cerebral cortex

21 January 2018

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Determination of the neurotoxin BMAA (beta-N-methylamino-L-alanine) in cycad seed and cyanobacteria by LC-MS/MS (liquid chromatography tandem mass spectrometry).

21 January 2018

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The ALS/PDC syndrome of Guam and the cycad hypothesis

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Corticobasal syndrome associated with the A9D Progranulin mutation

21 January 2018

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Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family.

21 January 2018

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Identification of a novel founder mutation in the DYSF gene causing clinical variability in the Spanish population.

21 January 2018

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Selective degeneration of cerebellar cortical neurons caused by cycad neurotoxin, L-beta-methylaminoalanine (L-BMAA), in rats

21 January 2018

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Behavioral and neurological correlates of ALS-parkinsonism dementia complex in adult mice fed washed cycad flour

21 January 2018

1 reference

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Decrease in Glial Glutamate Transporter Variants and Excitatory Amino Acid Receptor Down-Regulation in a Murine Model of ALS-PDC

21 January 2018

1 reference

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Examining the interaction of apo E and neurotoxicity on a murine model of ALS-PDC.

21 January 2018

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Analysis of neurological disease in four dimensions: insight from ALS-PDC epidemiology and animal models

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Novel environmental toxins: steryl glycosides as a potential etiological factor for age-related neurodegenerative diseases

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Neurodegenerative diseases: neurotoxins as sufficient etiologic agents?

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Chronic exposure to dietary sterol glucosides is neurotoxic to motor neurons and induces an ALS-PDC phenotype.

21 January 2018

1 reference

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Lack of behavioral and neuropathological effects of dietary beta-methylamino-L-alanine (BMAA) in mice

21 January 2018

1 reference

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Isolation of various forms of sterol beta-D-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia complex

21 January 2018

1 reference

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Cycad toxins, Helicobacter pylori and parkinsonism: cholesterol glucosides as the common denomenator

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beta-Sitosterol and beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as an immunomodulatory vitamin combination

21 January 2018

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Neurochemical and neurobehavioral effects of neonatal administration of beta-N-methylamino-L-alanine and 3,3'-iminodipropionitrile

21 January 2018

1 reference

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Premorbid weight, body mass, and varsity athletics in ALS.

21 January 2018

1 reference

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Genetic susceptibility to environmental toxicants in ALS.

21 January 2018

1 reference

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Progranulin gene mutation with an unusual clinical and neuropathologic presentation

21 January 2018

1 reference

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10.3109/17482960903286009

21 January 2018

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DOI

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30 July 2017

1 reference