Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress (Q33991775)

30 July 2017

1 reference

title

Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress (English)

1 reference

30 July 2017

Vera Adam-Vizi

2

0 references

author name string

Laszlo Tretter

series ordinal

1

1 reference

30 July 2017

language of work or name

English

0 references

publication date

1 December 2005

1 reference

Philosophical Transactions of the Royal Society B

30 July 2017

published in

1 reference

30 July 2017

volume

360

1 reference

30 July 2017

issue

1464

1 reference

30 July 2017

page(s)

2335-2345

1 reference

Zinc and excitotoxic brain injury: a new model.

30 July 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Mitochondrial formation of reactive oxygen species

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

2-Oxo acid dehydrogenase complexes in redox regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Experimental models of Parkinson's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Myxothiazol induces H(2)O(2) production from mitochondrial respiratory chain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Zn(2+): a novel ionic mediator of neural injury in brain disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Exacerbated responses to oxidative stress by an Na(+) load in isolated nerve terminals: the role of ATP depletion and rise of [Ca(2+)](i).

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an animal model of chronic oxidative deficits

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Effects of oxidants and glutamate receptor activation on mitochondrial membrane potential in rat forebrain neurons.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Secondary inhibition of 2-ketoglutarate dehydrogenase complex by MPTP.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Enhanced depolarization-evoked calcium signal and reduced [ATP]/[ADP] ratio are unrelated events induced by oxidative stress in synaptosomes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Mitochondria, free radicals, and neurodegeneration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Sequestration of glutamate-induced Ca2+ loads by mitochondria in cultured rat hippocampal neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Activation of molecular oxygen by flavins and flavoproteins.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Oxidative stress, glutamate, and neurodegenerative disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Superoxide radical and iron modulate aconitase activity in mammalian cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat: correlation with the cytotoxic potential of H2O2 in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

4-Hydroxynonenal, a novel indicator of lipid peroxidation for reperfusion injury of the myocardium.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

A radical hypothesis for neurodegeneration

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Tricarboxylic acid cycle flux and enzyme activities in the isolated working rat heart

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

A familial progressive neurodegenerative disease with 2-oxoglutaric aciduria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

On the role of the calcium transport cycle in heart and other mammalian mitochondria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Regional enzyme development in rat brain. Enzymes of energy metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Alpha-ketoglutarate and malate uptake and metabolism by synaptosomes: further evidence for an astrocyte-to-neuron metabolic shuttle

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Calcium inhibition of the NAD+-linked isocitrate dehydrogenase from blowfly flight muscle mitochondria.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Energy-metabolizing enzymes in brain regions of adult and aging rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Effect of micromolar concentrations of free calcium ions on the reduction of heart mitochondrial NAD(P) by 2-oxoglutarate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

The cellular production of hydrogen peroxide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Regulation of mitochondrial alpha-ketoglutarate metabolism by product inhibition at alpha-ketoglutarate dehydrogenase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer's disease brain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

The importance of free radicals and catalytic metal ions in human diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Reduced Activities of Thiamine-Dependent Enzymes in the Brains and Peripheral Tissues of Patients With Alzheimer's Disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Influence of NAD-linked dehydrogenase activity on flux through oxidative phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Postmortem changes in mitochondrial respiratory enzymes in brain and a preliminary observation in Parkinson's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Free radicals in central nervous system ischemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

The oxidative inactivation of mitochondrial electron transport chain components and ATPase.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Mitochondrial complex I deficiency in Parkinson's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

The relationship between oxygen radical generation and impairment of myocardial energy metabolism following post-ischemic reperfusion,

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Pyridine nucleotide redox state parallels production of aldosterone in potassium-stimulated adrenal glomerulosa cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Mechanisms of generation of oxygen radicals and reductive mobilization of ferritin iron by lipoamide dehydrogenase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Reactive oxygen species and the central nervous system

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Ca(2+)-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Calcium ions and the regulation of NAD+-linked isocitrate dehydrogenase from the mitochondria of rat heart and other tissues

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Role of ubiquinone in the mitochondrial generation of hydrogen peroxide

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

The effects of calcium ions and adenine nucleotides on the activity of pig heart 2-oxoglutarate dehydrogenase complex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH–ubiquinone reductase preparation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Synaptic and non-synaptic mitochondria from rat brain: isolation and characterization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Beta-amyloid inhibits integrated mitochondrial respiration and key enzyme activities

5 July 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Influence of the Malate-Aspartate Shuttle on Oxidative Metabolism in Synaptosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Mitochondria deficient in complex I activity are depolarized by hydrogen peroxide in nerve terminals: relevance to Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Depolarization of in situ mitochondria due to hydrogen peroxide-induced oxidative stress in nerve terminals: inhibition of alpha-ketoglutarate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Limitation of glycolysis by hexokinase in rat brain synaptosomes during intense ion pumping

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Alpha-ketoglutarate dehydrogenase in Alzheimer brains bearing the APP670/671 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Regional alterations of thiamine phosphate esters and of thiamine diphosphate-dependent enzymes in relation to function in experimental Wernicke's encephalopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Selective loss of KGDHC-enriched neurons in Alzheimer temporal cortex: does mitochondrial variation contribute to selective vulnerability?

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Generation of reactive oxygen species by the mitochondrial electron transport chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Immunoreactive levels of alpha-ketoglutarate dehydrogenase subunits in Friedreich's ataxia and spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Frontotemporal dementia: neuropil spheroids and presynaptic terminal degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Modulation of mitochondrial function by hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Quantitative relationship between inhibition of respiratory complexes and formation of reactive oxygen species in isolated nerve terminals

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

The production of reactive oxygen species in intact isolated nerve terminals is independent of the mitochondrial membrane potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Generation of reactive oxygen species in the reaction catalyzed by alpha-ketoglutarate dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1098%2FRSTB.2005.1764

Regulation of brain mitochondrial H2O2 production by membrane potential and NAD(P)H redox state.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Requirement for superoxide in excitotoxic cell death

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Brain hydroxyl radical generation in acute experimental head injury

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1569585

Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome

29 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Zn2+ inhibits alpha-ketoglutarate-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate dehydrogenase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Some kinetic properties of pig-heart oxoglutarate dehydrogenase that provide a basis for metabolic control of the enzyme activity and also a stoicheiometric assay for coenzyme A in tissue extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Direct demonstration of superoxide anion production during the oxidation of reduced flavin and of its catalytic decomposition by erythrocuprein

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Function of calcium ions in pyruvate dehydrogenase phosphatase activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Mitochondrial H2O2 formation: relationship with energy conservation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Properties and subunit composition of the pig heart 2-oxoglutarate dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Superoxide radicals as precursors of mitochondrial hydrogen peroxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Structure, assembly and function of mammalian alpha-keto acid dehydrogenase complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Glyceraldehyde-3-phosphate dehydrogenase-catalyzed chain oxidation of reduced nicotinamide adenine dinucleotide by perhydroxyl radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Free radicals, lipid peroxidation, and cell damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

The respiratory burst oxidase of neutrophils. Separation of an FAD enzyme and its characterization

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Oxygen free radical involvement in ischemia and reperfusion injury to brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

2-Oxoglutarate: oxidation and role as a potential precursor of cytosolic acetyl-CoA for the synthesis of acetylcholine in rat brain synaptosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Mitochondrial complex I deficiency in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Abnormalities of the electron transport chain in idiopathic Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Glutamate, calcium, and free radicals as mediators of ischemic brain damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Glutamate induces the production of reactive oxygen species in cultured forebrain neurons following NMDA receptor activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Inhibition of α-Ketoglutarate dehydrogenase by isoquinoline derivatives structurally related to 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

The role of zinc in selective neuronal death after transient global cerebral ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Mitochondrial dysfunction in Parkinson's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Generation of superoxide anion by succinate-cytochrome c reductase from bovine heart mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

An oxidase for reduced diphosphopyridine nucleotide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Evidence that mitochondrial respiration is a source of potentially toxic oxygen free radicals in intact rabbit hearts subjected to ischemia and reflow

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Brain alpha-ketoglutarate dehydrogenase complex activity in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16321804

12 December 2020

Identifiers

DOI

10.1098/RSTB.2005.1764

1 reference

30 July 2017

1 reference

30 July 2017

1 reference