An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice (Q33943166)

30 July 2017

title

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice (English)

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30 July 2017

14

Z Gaciong

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30 July 2017

K Podsypanina

1

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R T Lee

2

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C Politis

3

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I Hennessy

4

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A Crane

5

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J Puc

6

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M Neshat

7

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H Wang

8

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L Yang

9

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J Gibbons

10

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P Frost

11

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V Dreisbach

12

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J Blenis

13

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P Fisher

15

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C Sawyers

16

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L Hedrick-Ellenson

17

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R Parsons

18

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language of work or name

English

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publication date

14 August 2001

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

published in

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30 July 2017

volume

98

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30 July 2017

issue

18

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30 July 2017

page(s)

10320-10325

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A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.

30 July 2017

cites work

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Regulation of cellular growth by the Drosophila target of rapamycin dTOR

5 July 2018

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Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

5 July 2018

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Multiple genes at 17q23 undergo amplification and overexpression in breast cancer

5 July 2018

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Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis

5 July 2018

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A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

5 July 2018

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Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways

5 July 2018

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Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

5 July 2018

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Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

5 July 2018

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Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

5 July 2018

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p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes

5 July 2018

1 reference

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

5 July 2018

1 reference

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

5 July 2018

1 reference

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Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

5 July 2018

1 reference

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Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

5 July 2018

1 reference

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

5 July 2018

1 reference

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

5 July 2018

1 reference

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

5 July 2018

1 reference

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Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

5 July 2018

1 reference

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Studies on the mechanism of resistance to rapamycin in human cancer cells

5 July 2018

1 reference

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

5 July 2018

1 reference

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Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

5 July 2018

1 reference

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Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity

5 July 2018

1 reference

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4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

5 July 2018

1 reference

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

5 July 2018

1 reference

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Phosphorylation and activation of p70s6k by PDK1

5 July 2018

1 reference

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

5 July 2018

1 reference

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Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

5 July 2018

1 reference

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Rapamycin resistance tied to defective regulation of p27Kip1.

5 July 2018

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Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

5 July 2018

1 reference

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

5 July 2018

1 reference

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

5 July 2018

1 reference

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Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=56959

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

5 July 2018

1 reference

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

5 July 2018

1 reference

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=56959

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=56959

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=56959

Drosophila S6 kinase: a regulator of cell size

5 July 2018

1 reference

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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.171060098

Identification of kinase-phosphatase signaling modules composed of p70 S6 kinase-protein phosphatase 2A (PP2A) and p21-activated kinase-PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.171060098

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.171060098

p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin.

21 January 2018

1 reference

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PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=56959

Rapamycin inhibits ribosomal protein synthesis and induces G1 prolongation in mitogen-activated T lymphocytes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=56959

Perspectives: cell biology. All creatures great and small

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/11504907

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.171060098

1 reference

30 July 2017

0 references

1 reference

30 July 2017

1 reference