The sevenless signaling pathway: variations of a common theme (Q33894558)

29 July 2017

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title

The sevenless signaling pathway: variations of a common theme (English)

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sevenless signaling pathway

29 July 2017

main subject

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Gene Ontology release 2020-05-02

T Raabe

1

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29 July 2017

language of work or name

English

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publication date

1 April 2000

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Biochimica et Biophysica Acta

29 July 2017

published in

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29 July 2017

volume

1496

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29 July 2017

issue

2-3

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29 July 2017

page(s)

151-163

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The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog.

29 July 2017

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Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase.

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Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye.

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A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

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An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

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The Son of sevenless Gene Product: a Putative Activator of Ras

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Biochemical and genetic analysis of the Drk SH2/SH3 adaptor protein of Drosophila.

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In vivo functional analysis of the Ras exchange factor son of sevenless

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Functional Roles for the Pleckstrin and Dbl Homology Regions in the Ras Exchange Factor Son-of-sevenless

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Protein modules and signalling networks

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The IRS-signalling system during insulin and cytokine action

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation

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DOS, a novel pleckstrin homology domain-containing protein required for signal transduction between sevenless and Ras1 in Drosophila.

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The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila

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Daughter of sevenless is a substrate of the phosphotyrosine phosphatase Corkscrew and functions during sevenless signaling

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The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling

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In vivo functional analysis of the daughter of sevenless protein in receptor tyrosine kinase signaling

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Genetic analysis of protein tyrosine phosphatases

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Opposing actions of CSW and RasGAP modulate the strength of Torso RTK signaling in the Drosophila terminal pathway.

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A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase

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7 January 2021

mip causes hyperinnervation of a retinotopic map in drosophila by excessive recruitment of R7 photoreceptor cells

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7 January 2021

sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways

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7 January 2021

Sprouty, an intracellular inhibitor of Ras signaling.

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7 January 2021

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

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7 January 2021

Increasing complexity of the Ras signaling pathway

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7 January 2021

Ras--a versatile cellular switch

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7 January 2021

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

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7 January 2021

The complexity of Raf-1 regulation

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7 January 2021

Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation.

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7 January 2021

Raf functions downstream of Ras1 in the Sevenless signal transduction pathway

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7 January 2021

14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila

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7 January 2021

Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development

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Negative regulation of Raf activity by binding of 14-3-3 to the amino terminus of Raf in vivo.

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7 January 2021

The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway.

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CNK, a RAF-binding multidomain protein required for RAS signaling

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7 January 2021

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

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The C. elegans ksr-1 gene encodes a novel Raf-related kinase involved in Ras-mediated signal transduction

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7 January 2021

KSR, a novel protein kinase required for RAS signal transduction

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Kinase suppressor of Ras is ceramide-activated protein kinase

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KSR modulates signal propagation within the MAPK cascade

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KSR stimulates Raf-1 activity in a kinase-independent manner

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Murine Ksr interacts with MEK and inhibits Ras-induced transformation

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The protein kinase KSR interacts with 14-3-3 protein and Raf.

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Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK.

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Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase

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7 January 2021

The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.

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A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways

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PTP-ER, a novel tyrosine phosphatase, functions downstream of Ras1 to downregulate MAP kinase during Drosophila eye development

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The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action

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The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation

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Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein

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7 January 2021

pokkuri, a Drosophila gene encoding an E-26-specific (Ets) domain protein, prevents overproduction of the R7 photoreceptor

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7 January 2021

The Drosophila Fos-related AP-1 protein is a developmentally regulated transcription factor

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7 January 2021

Drosophila homolog of the mammalian jun oncogene is expressed during embryonic development and activates transcription in mammalian cells

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Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure

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Drosophila Jun relays the Jun amino-terminal kinase signal transduction pathway to the Decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement

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The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by the Ras/MAPK pathway

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The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

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Yan functions as a general inhibitor of differentiation and is negatively regulated by activation of the Ras1/MAPK pathway.

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7 January 2021

Control of Drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the Raf kinase

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7 January 2021

phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila

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7 January 2021

seven in absentia, a gene required for specification of R7 cell fate in the Drosophila eye.

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tramtrack is a transcriptional repressor required for cell fate determination in the Drosophila eye.

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7 January 2021

Photoreceptor cell differentiation requires regulated proteolysis of the transcriptional repressor Tramtrack.

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7 January 2021

PHYL acts to down-regulate TTK88, a transcriptional repressor of neuronal cell fates, by a SINA-dependent mechanism.

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7 January 2021

Loss of tramtrack gene activity results in ectopic R7 cell formation, even in a sina mutant background

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7 January 2021

ebi regulates epidermal growth factor receptor signaling pathways in Drosophila

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7 January 2021

Transcription factors in eye development: a gorgeous mosaic?

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7 January 2021

Reprogramming cell fate in the developing Drosophila retina: transformation of R7 cells by ectopic expression of rough.

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7 January 2021

The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype

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7 January 2021

The Drosophila seven-up gene, a member of the steroid receptor gene superfamily, controls photoreceptor cell fates

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7 January 2021

Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the sevenless receptor tyrosine kinase

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7 January 2021

10.1016/S0167-4889(00)00020-3

Identifiers

DOI

1 reference

29 July 2017

1 reference