Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs. (Q33879099)

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5 November 2019

review article

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title

Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs (English)

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5 November 2019

2

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5 November 2019

Barbara Marleen Bakker

series ordinal

1

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5 November 2019

Fred Opperdoes

series ordinal

3

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5 November 2019

author name string

P A Michels

series ordinal

4

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5 November 2019

publication date

1 February 2000

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Molecular and Biochemical Parasitology

5 November 2019

published in

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5 November 2019

volume

106

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5 November 2019

issue

1

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5 November 2019

page(s)

1-10

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Molecular mechanisms and therapeutic approaches to the treatment of African trypanosomiasis

5 November 2019

cites work

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Structure-based drug design: progress, results and challenges

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Recent advances in identifying and validating drug targets in trypanosomes and leishmanias.

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Compartmentation of glycolysis in trypanosomes: a potential target for new trypanocidal drugs

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7 January 2021

Compartmentation of carbohydrate metabolism in trypanosomes

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7 January 2021

Structure, function, and biogenesis of glycosomes in kinetoplastida

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7 January 2021

Inhibition of the glycolytic enzymes in the trypanosome: an approach in the development of new leads in the therapy of parasitic diseases

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7 January 2021

Subcellular Compartmentation of Glycolytic Intermediates in Trypanosoma brucei

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7 January 2021

Compartmentation of phosphoglycerate kinase in Trypanosoma brucei plays a critical role in parasite energy metabolism

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7 January 2021

Specificity of glucose transport in Trypanosoma brucei. Effective inhibition by phloretin and cytochalasin B

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Inhibition of glyceraldehyde-3-phosphate dehydrogenase by pentalenolactone in Trypanosoma brucei

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7 January 2021

The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications.

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7 January 2021

New approach to screening drugs for activity against African trypanosomes

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7 January 2021

Trypanosoma brucei: Trypanocidal effect of salicylhydroxamic acid plus glycerol in infected rats

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7 January 2021

An antibiotic, ascofuranone, specifically inhibits respiration and in vitro growth of long slender bloodstream forms of Trypanosoma brucei brucei

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7 January 2021

Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.

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7 January 2021

Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase

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7 January 2021

Crystal Structure of Glycosomal Glyceraldehyde-3-phosphate Dehydrogenase from Leishmania mexicana: Implications for Structure-Based Drug Design and a New Position for the Inorganic Phosphate Binding Site

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7 January 2021

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

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7 January 2021

A Linear Steady-State Treatment of Enzymatic Chains. General Properties, Control and Effector Strength

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7 January 2021

Metabolic control analysis: a survey of its theoretical and experimental development

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7 January 2021

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7 January 2021

Regulation and control of compartmentalized glycolysis in bloodstream form Trypanosoma brucei

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7 January 2021

Glycolysis in bloodstream form Trypanosoma brucei can be understood in terms of the kinetics of the glycolytic enzymes.

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7 January 2021

What Controls Glycolysis in Bloodstream FormTrypanosoma brucei?

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7 January 2021

Contribution of glucose transport to the control of the glycolytic flux in Trypanosoma brucei

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7 January 2021

Differential regulation of two distinct families of glucose transporter genes in Trypanosoma brucei

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Sugar transporters from bacteria, parasites and mammals: structure-activity relationships

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Prospects for antiparasitic drugs. The case of Trypanosoma brucei, the causative agent of African sleeping sickness

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Purification, morphometric analysis, and characterization of the glycosomes (microbodies) of the protozoan hemoflagellate Trypanosoma brucei

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7 January 2021

10.1016/S0166-6851(99)00197-8

Identifiers

DOI

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5 November 2019

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