Molecular genetics of Alzheimer's disease. (Q33842568)

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4 November 2019

review article

1 reference

title

Molecular genetics of Alzheimer's disease (English)

1 reference

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4 November 2019

0 references

Peter Henry St George-Hyslop

series ordinal

1

1 reference

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4 November 2019

author name string

St George-Hyslop PH

series ordinal

1

1 reference

29 July 2017

language of work or name

English

0 references

publication date

1 February 2000

1 reference

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4 November 2019

published in

Biological Psychiatry

1 reference

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4 November 2019

volume

47

1 reference

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4 November 2019

issue

3

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4 November 2019

page(s)

183-199

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ApoE genotype and survival from intracerebral haemorrhage

4 November 2019

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Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes

7 January 2021

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Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

7 January 2021

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Wide range in age of onset for chromosome 1--related familial Alzheimer's disease

7 January 2021

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Alpha-2 macroglobulin is genetically associated with Alzheimer disease

7 January 2021

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

7 January 2021

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Cloning and characterization of the Drosophila presenilin homologue

7 January 2021

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Analysis of the butyrylcholinesterase gene and nearby chromosome 3 markers in Alzheimer disease

7 January 2021

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Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling

7 January 2021

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A polymorphism in the regulatory region of APOE associated with risk for Alzheimer's dementia.

7 January 2021

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Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

7 January 2021

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The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

7 January 2021

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene

7 January 2021

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

7 January 2021

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

7 January 2021

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Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease

7 January 2021

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Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

7 January 2021

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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

7 January 2021

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

7 January 2021

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The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations

7 January 2021

1 reference

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An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

7 January 2021

1 reference

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

7 January 2021

1 reference

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

7 January 2021

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Protein topology of presenilin 1

7 January 2021

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

7 January 2021

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A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

7 January 2021

1 reference

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No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample.

7 January 2021

1 reference

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Presenilin 1 is actively degraded by the 26S proteasome

7 January 2021

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

7 January 2021

1 reference

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Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

7 January 2021

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Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

7 January 2021

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Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family

7 January 2021

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Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

7 January 2021

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The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway

7 January 2021

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

7 January 2021

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No genetic effect of alpha1-antichymotrypsin in Alzheimer disease.

7 January 2021

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Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

7 January 2021

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Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans

7 January 2021

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Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

7 January 2021

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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

7 January 2021

1 reference

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Alzheimer's disease: a study of epidemiological aspects.

7 January 2021

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Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease

7 January 2021

1 reference

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Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.

7 January 2021

1 reference

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ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation

7 January 2021

1 reference

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Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

7 January 2021

1 reference

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Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene.

7 January 2021

1 reference

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APOE*4-associated Alzheimer's disease risk is modified by alpha 1-antichymotrypsin polymorphism.

7 January 2021

1 reference

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Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease

7 January 2021

1 reference

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

7 January 2021

1 reference

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Molecular and prospective phenotypic characterization of a pedigree with familial Alzheimer's disease and a missense mutation in codon 717 of the beta-amyloid precursor protein gene

7 January 2021

1 reference

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Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease

7 January 2021

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7 January 2021

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Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype.

7 January 2021

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A new polymorphism in the APOE promoter associated with risk of developing Alzheimer's disease.

7 January 2021

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Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE study: What is in store for the oldest old?

7 January 2021

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Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues

7 January 2021

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A detergent-insoluble membrane compartment contains A beta in vivo

7 January 2021

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Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease

7 January 2021

1 reference

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Evidence for a six-transmembrane domain structure of presenilin 1.

7 January 2021

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Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population

7 January 2021

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Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

7 January 2021

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Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

7 January 2021

1 reference

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Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type

7 January 2021

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A familial Alzheimer's disease locus on chromosome 1.

7 January 2021

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Mutation of a putative sperm membrane protein in Caenorhabditis elegans prevents sperm differentiation but not its associated meiotic divisions

7 January 2021

1 reference

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Membrane topology of the C. elegans SEL-12 presenilin

7 January 2021

1 reference

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Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

7 January 2021

1 reference

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Apolipoprotein E and Alzheimer's disease: ethnic variation in genotypic risks.

7 January 2021

1 reference

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Neurodegeneration in the central nervous system of apoE-deficient mice

7 January 2021

1 reference

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beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

7 January 2021

1 reference

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Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium

7 January 2021

1 reference

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Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease.

7 January 2021

1 reference

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Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease

7 January 2021

1 reference

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A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

7 January 2021

1 reference

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A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease

7 January 2021

1 reference

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ApoE genotype and familial Alzheimer's disease: a possible influence on age of onset in APP717 Val-->Ile mutated families.

7 January 2021

1 reference

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Mis-sense mutation Val&rarr;Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease

7 January 2021

1 reference

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Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

7 January 2021

1 reference

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The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

7 January 2021

1 reference

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Predictors of cognitive decline after cardiac operation

7 January 2021

1 reference

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Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

7 January 2021

1 reference

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Ligand-dependent G protein coupling function of amyloid transmembrane precursor

7 January 2021

1 reference

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Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease

7 January 2021

1 reference

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The apolipoprotein E epsilon 4 allele is associated with increased neuritic plaques and cerebral amyloid angiopathy in Alzheimer's disease and Lewy body variant

7 January 2021

1 reference

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Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12.

7 January 2021

1 reference

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Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

7 January 2021

1 reference

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Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

7 January 2021

1 reference

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Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

7 January 2021

1 reference

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Reduced apolipoprotein epsilon 4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals.

7 January 2021

1 reference

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Epidemiology of clinically diagnosed Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900301-7

Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity

7 January 2021

1 reference

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

7 January 2021

1 reference

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Head injury, amyloid β and Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900301-7

Splicing mutation of presenilin-1 gene for early-onset familial Alzheimer's disease.

7 January 2021

2 references

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900301-7

inferred from DOI database lookup

7 January 2021

based on heuristic

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900301-7

Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900301-7

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900301-7

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-3223%2899%2900301-7

Presenilin-1 polymorphism and Alzheimer's disease

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

7 January 2021

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7 January 2021

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Genetic association between intronic polymorphism in presenilin-1 gene and late-onset Alzheimer's disease. Alzheimer's Disease Collaborative Group

7 January 2021

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Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease

7 January 2021

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G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP.

7 January 2021

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Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

7 January 2021

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The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

7 January 2021

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Presenilin 1 interaction in the brain with a novel member of the Armadillo family

7 January 2021

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10.1016/S0006-3223(99)00301-7

7 January 2021

Identifiers

DOI

1 reference

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4 November 2019

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