Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways. (Q33824746)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

review article

1 reference

title

Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

0 references

1

1 reference

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1 November 2019

author name string

P Russell

series ordinal

2

1 reference

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1 November 2019

language of work or name

English

0 references

publication date

1 November 2000

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1 November 2019

number of pages

8

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inferred from page(s)

published in

Journal of Cell Science

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1 November 2019

volume

113 ( Pt 22)

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1 November 2019

page(s)

3889-3896

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

1 November 2019

cites work

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Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

4 July 2018

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Rapid destruction of human Cdc25A in response to DNA damage

4 July 2018

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Response of Xenopus Cds1 in cell-free extracts to DNA templates with double-stranded ends

4 July 2018

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Drosophila wee1 has an essential role in the nuclear divisions of early embryogenesis

4 July 2018

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The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

4 July 2018

1 reference

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The G(2) DNA damage checkpoint targets both Wee1 and Cdc25.

4 July 2018

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The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation

4 July 2018

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An ATM homologue from Arabidopsis thaliana: complete genomic organisation and expression analysis.

4 July 2018

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hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response

4 July 2018

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Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis

4 July 2018

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

4 July 2018

1 reference

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ATR disruption leads to chromosomal fragmentation and early embryonic lethality

4 July 2018

1 reference

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

4 July 2018

1 reference

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An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage

4 July 2018

1 reference

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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

4 July 2018

1 reference

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Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53

4 July 2018

1 reference

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Characterization of a Saccharomyces cerevisiae homologue of Schizosaccharomyces pombe Chk1 involved in DNA-damage-induced M-phase arrest

4 July 2018

1 reference

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Regulation of mitotic inhibitor Mik1 helps to enforce the DNA damage checkpoint

4 July 2018

1 reference

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DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis

4 July 2018

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Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome

4 July 2018

1 reference

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DNA replication checkpoint control

4 July 2018

1 reference

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Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase.

4 July 2018

1 reference

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DNA damage and replication checkpoints in fission yeast require nuclear exclusion of the Cdc25 phosphatase via 14-3-3 binding

4 July 2018

1 reference

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The FHA domain is a modular phosphopeptide recognition motif.

4 July 2018

1 reference

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Drosophila grapes/CHK1 mutants are defective in cyclin proteolysis and coordination of mitotic events

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

4 July 2018

1 reference

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RAD53, DUN1 and PDS1 define two parallel G2/M checkpoint pathways in budding yeast

4 July 2018

1 reference

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Basis for the checkpoint signal specificity that regulates Chk1 and Cds1 protein kinases

4 July 2018

1 reference

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The Pds1 anaphase inhibitor and Mec1 kinase define distinct checkpoints coupling S phase with mitosis in budding yeast

4 July 2018

1 reference

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Cdc25 inhibited in vivo and in vitro by checkpoint kinases Cds1 and Chk1

4 July 2018

1 reference

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4 July 2018

1 reference

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Mitotic DNA damage and replication checkpoints in yeast

4 July 2018

1 reference

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A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

4 July 2018

1 reference

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Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

4 July 2018

1 reference

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A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication

4 July 2018

1 reference

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DNA damage checkpoint in budding yeast.

4 July 2018

1 reference

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The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts

4 July 2018

1 reference

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Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathway

4 July 2018

1 reference

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The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor

4 July 2018

1 reference

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Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint

4 July 2018

1 reference

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Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

4 July 2018

1 reference

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Tyrosine phosphorylation of cdc2 is required for the replication checkpoint in Schizosaccharomyces pombe

4 July 2018

1 reference

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Replication checkpoint enforced by kinases Cds1 and Chk1.

4 July 2018

1 reference

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C-TAK1 protein kinase phosphorylates human Cdc25C on serine 216 and promotes 14-3-3 protein binding

4 July 2018

1 reference

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S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe

4 July 2018

1 reference

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The anaphase inhibitor of Saccharomyces cerevisiae Pds1p is a target of the DNA damage checkpoint pathway

4 July 2018

1 reference

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Cell-cycle signaling: Atm displays its many talents

4 July 2018

1 reference

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Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae

4 July 2018

1 reference

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Maintaining genetic stability through TP53 mediated checkpoint control.

4 July 2018

1 reference

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Control of S-phase periodic transcription in the fission yeast mitotic cycle

4 July 2018

1 reference

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A dual-specificity phosphatase Cdc25B is an unstable protein and triggers p34(cdc2)/cyclin B activation in hamster BHK21 cells arrested with hydroxyurea.

4 July 2018

1 reference

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Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216

4 July 2018

1 reference

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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

4 July 2018

1 reference

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DNA-replication checkpoint control at the Drosophila midblastula transition

4 July 2018

1 reference

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The role of inhibitory phosphorylation of CDC2 following DNA replication block and radiation-induced damage in human cells

4 July 2018

1 reference

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Reconstitution of a MEC1-independent checkpoint in yeast by expression of a novel human fork head cDNA

4 July 2018

1 reference

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Inactivation of the cyclin-dependent kinase Cdc28 abrogates cell cycle arrest induced by DNA damage and disassembly of mitotic spindles in Saccharomyces cerevisiae

4 July 2018

1 reference

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Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.

4 July 2018

1 reference

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The Schizosaccharomyces pombe rad3 checkpoint gene

4 July 2018

1 reference

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Cell cycle checkpoints: preventing an identity crisis

4 July 2018

1 reference

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Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

Fission yeast chk1 protein kinase links the rad checkpoint pathway to cdc2.

4 July 2018

1 reference

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DUN1 encodes a protein kinase that controls the DNA damage response in yeast

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

Purification of a serine kinase that associates with and phosphorylates human Cdc25C on serine 216.

4 July 2018

1 reference

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The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

4 July 2018

Cdc2 regulatory factors

1 reference

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Characterization of G1 checkpoint control in the yeast Saccharomyces cerevisiae following exposure to DNA-damaging agents

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

4 July 2018

1 reference

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A cell cycle checkpoint monitors cell morphogenesis in budding yeast

4 July 2018

1 reference

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DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

4 July 2018

1 reference

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4 July 2018

1 reference

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The FHA domain: a putative nuclear signalling domain found in protein kinases and transcription factors

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

Checkpoints: controls that ensure the order of cell cycle events

4 July 2018

1 reference

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

The Drosophila grapes gene is related to checkpoint gene chk1/rad27 and is required for late syncytial division fidelity

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

A kinase from fission yeast responsible for blocking mitosis in S phase

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

The mei-41 gene of D. melanogaster is a structural and functional homolog of the human ataxia telangiectasia gene

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863124

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

29 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/11058076

12 December 2020

Regulation of DNA-replication origins during cell-cycle progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/11058076

12 December 2020

Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/11058076

12 December 2020

Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/11058076

12 December 2020

A S/M DNA replication checkpoint prevents nuclear and cytoplasmic events of cell division including centrosomal axis alignment and inhibits activation of cyclin-dependent kinase-like proteins in fucoid zygotes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11058076

12 December 2020

Fission yeast wee1 protein kinase is not required for DMA damage-dependent mitotic arrest

1 reference

https://pubmed.ncbi.nlm.nih.gov/11058076

12 December 2020

Cdc2 tyrosine phosphorylation is required for the DNA damage checkpoint in fission yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/11058076

12 December 2020

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/11058076

12 December 2020

A DNA damage checkpoint meets the cell cycle engine

1 reference

https://pubmed.ncbi.nlm.nih.gov/11058076

12 December 2020

CDC5 and CKII control adaptation to the yeast DNA damage checkpoint

1 reference

https://pubmed.ncbi.nlm.nih.gov/11058076

12 December 2020

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11058076%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

PubMed publication ID

11058076

1 reference