Organization of proximal signal initiation at the TCR:CD3 complex (Q33753888)

29 July 2017

1 reference

title

Organization of proximal signal initiation at the TCR:CD3 complex (English)

1 reference

29 July 2017

2

Dario A A Vignali

1 reference

29 July 2017

Clifford S Guy

1

1 reference

29 July 2017

publication date

1 November 2009

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29 July 2017

published in

Immunological Reviews

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29 July 2017

volume

232

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29 July 2017

issue

1

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29 July 2017

page(s)

7-21

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The cellular context of T cell signaling

29 July 2017

cites work

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Th1 and Th2 cells form morphologically distinct immunological synapses.

21 June 2018

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Structural and Functional Evidence that Nck Interaction with CD3ε Regulates T-Cell Receptor Activity

21 June 2018

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T-cell activation through immunological synapses and kinapses

21 June 2018

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The receptor deformation model of TCR triggering

21 June 2018

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Common themes in the assembly and architecture of activating immune receptors

21 June 2018

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c-Cbl-mediated regulation of LAT-nucleated signaling complexes

21 June 2018

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Distinct roles for Syk and ZAP-70 during early thymocyte development

21 June 2018

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Protein kinase C theta (PKCtheta): a key player in T cell life and death

21 June 2018

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Lipid-binding activity of intrinsically unstructured cytoplasmic domains of multichain immune recognition receptor signaling subunits

21 June 2018

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Recruitment of dynein to the Jurkat immunological synapse

21 June 2018

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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

21 June 2018

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The kinetic-segregation model: TCR triggering and beyond

21 June 2018

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How TCRs bind MHCs, peptides, and coreceptors

21 June 2018

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Deconstructing the form and function of the TCR/CD3 complex

21 June 2018

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The CD3 gamma epsilon/delta epsilon signaling module provides normal T cell functions in the absence of the TCR zeta immunoreceptor tyrosine-based activation motifs

21 June 2018

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Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

21 June 2018

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Tuning immune responses: diversity and adaptation of the immunological synapse.

21 June 2018

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The CD3epsilon proline-rich sequence, and its interaction with Nck, is not required for T cell development and function

21 June 2018

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How T cells 'see' antigen

21 June 2018

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Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling

21 June 2018

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Protein kinase C theta is critical for the development of in vivo T helper (Th)2 cell but not Th1 cell responses

21 June 2018

1 reference

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B cell antigen receptor signaling 101.

21 June 2018

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Evidence that structural rearrangements and/or flexibility during TCR binding can contribute to T cell activation

21 June 2018

1 reference

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CD28-mediated co-stimulation: a quantitative support for TCR signalling

21 June 2018

1 reference

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T-cell receptor signal transmission: who gives an ITAM?

21 June 2018

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A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase

21 June 2018

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Mechanism of recruitment of WASP to the immunological synapse and of its activation following TCR ligation

21 June 2018

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c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

21 June 2018

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Neural and immunological synaptic relations

21 June 2018

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T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

21 June 2018

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Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation

21 June 2018

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CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse

21 June 2018

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The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells

21 June 2018

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T cell receptor signaling precedes immunological synapse formation

21 June 2018

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CD4 T cells selected by antigen under Th2 polarizing conditions favor an elongated TCR alpha chain complementarity-determining region 3.

21 June 2018

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Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

21 June 2018

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Requirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell development

21 June 2018

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T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase

21 June 2018

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Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70.

21 June 2018

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Function of CD3 epsilon-mediated signals in T cell development

21 June 2018

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A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity

21 June 2018

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ITAM multiplicity and thymocyte selection: how low can you go?

21 June 2018

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Cbl-b regulates the CD28 dependence of T-cell activation.

21 June 2018

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Partially phosphorylated T cell receptor zeta molecules can inhibit T cell activation

21 June 2018

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The immunological synapse: a molecular machine controlling T cell activation

21 June 2018

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Essential role of LAT in T cell development

21 June 2018

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Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation

21 June 2018

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Adaptors and molecular scaffolds in immune cell signaling

21 June 2018

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

21 June 2018

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LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

21 June 2018

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Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

21 June 2018

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Differential requirements for ZAP-70 in TCR signaling and T cell development

21 June 2018

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A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts

21 June 2018

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Three-dimensional segregation of supramolecular activation clusters in T cells

21 June 2018

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LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation

21 June 2018

1 reference

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Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

21 June 2018

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 June 2018

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Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell

21 June 2018

1 reference

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The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages

21 June 2018

1 reference

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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 June 2018

1 reference

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The Cbl phosphotyrosine-binding domain selects a D(N/D)XpY motif and binds to the Tyr292 negative regulatory phosphorylation site of ZAP-70.

21 June 2018

1 reference

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T-cell signaling: the importance of receptor clustering

21 June 2018

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Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70

21 June 2018

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Protein tyrosine kinases in thymocyte development

21 June 2018

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The Vav binding site (Y315) in ZAP-70 is critical for antigen receptor-mediated signal transduction

21 June 2018

1 reference

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Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation

21 June 2018

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CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage

21 June 2018

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The single positive T cells found in CD3-zeta/eta-/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex

21 June 2018

1 reference

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Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness

21 June 2018

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Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function

21 June 2018

1 reference

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Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function

21 June 2018

1 reference

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Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845712

T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases

21 June 2018

1 reference

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Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845712

Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845712

Serial triggering of many T-cell receptors by a few peptide-MHC complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845712

Molecular basis for interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor

21 June 2018

1 reference

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Essential role for ZAP-70 in both positive and negative selection of thymocytes

21 June 2018

1 reference

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Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene

21 June 2018

1 reference

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ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity

21 June 2018

1 reference

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A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains

21 June 2018

1 reference

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Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line

21 June 2018

1 reference

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The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845712

Cell surface molecules and early events involved in human T lymphocyte activation.

21 June 2018

1 reference

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The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose

21 June 2018

1 reference

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The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845712

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction

21 June 2018

1 reference

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Adhesion receptors of the immune system

21 June 2018

1 reference

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The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845712

Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon.

21 June 2018

1 reference

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ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain

21 June 2018

1 reference

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The proline-rich sequence of CD3epsilon as an amplifier of low-avidity TCR signaling

21 June 2018

1 reference

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Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells

21 January 2018

1 reference

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https://api.crossref.org/works/10.1111%2FJ.1600-065X.2009.00843.X

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

21 January 2018

1 reference

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Localized diacylglycerol drives the polarization of the microtubule-organizing center in T cells

30 October 2018

1 reference

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The proline-rich sequence of CD3epsilon controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes

30 October 2018

1 reference

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Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice.

30 October 2018

1 reference

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T cells use two directionally distinct pathways for cytokine secretion.

30 October 2018

1 reference

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Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

30 October 2018

1 reference

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Multifocal structure of the T cell - dendritic cell synapse

30 October 2018

1 reference

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Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845712

A role for the immunological synapse in lineage commitment of CD4 lymphocytes.

30 October 2018

1 reference

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The immunological synapse balances T cell receptor signaling and degradation

30 October 2018

1 reference

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Continuous T cell receptor signaling required for synapse maintenance and full effector potential

30 October 2018

1 reference

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TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

30 October 2018

1 reference

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Direct observation of ligand recognition by T cells.

30 October 2018

1 reference

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Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection

30 October 2018

1 reference

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Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845712

Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide

30 October 2018

1 reference

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Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845712

Opposing Effects of PKCθ and WASp on Symmetry Breaking and Relocation of the Immunological Synapse

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845712

The 21- and 23-kD forms of TCRζ are generated by specific ITAM phosphorylations

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2845712

Analysis of immunoreceptor tyrosine-based activation motif (ITAM) binding to ZAP-70 by surface plasmon resonance

30 October 2018

1 reference

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PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

30 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

CD28 Signaling via VAV/SLP-76 Adaptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

Isolation of cDNA clones encoding T cell-specific membrane-associated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor zeta subunits and the CD3 gamma, delta and epsilon chains

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

Differential and multiple binding of signal transducing molecules to the ITAMs of the TCR-zeta chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

Cross-antagonism of a T cell clone expressing two distinct T cell receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19909352

12 December 2020

10.1111/J.1600-065X.2009.00843.X

Identifiers

DOI

1 reference

29 July 2017

1 reference

29 July 2017

1 reference