Molecular basis of pharmacotherapies for cognition in Down syndrome (Q33625613)

28 July 2017

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title

Molecular basis of pharmacotherapies for cognition in Down syndrome (English)

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28 July 2017

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Katheleen J Gardiner

1

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28 July 2017

publication date

4 December 2009

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Trends in Pharmacological Sciences

28 July 2017

published in

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28 July 2017

volume

31

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28 July 2017

issue

2

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28 July 2017

page(s)

66-73

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A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

28 July 2017

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Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801.

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Genotype-phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

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Vitamin E increases S100B-mediated microglial activation in an S100B-overexpressing mouse model of pathological aging

21 June 2018

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Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome

21 June 2018

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Supplementation with antioxidants and folinic acid for children with Down's syndrome: randomised controlled trial

21 June 2018

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Language development in Down syndrome: from the prelinguistic period to the acquisition of literacy

21 June 2018

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Alzheimer's disease in Down syndrome: neurobiology and risk.

21 June 2018

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Anti-dementia drugs and hippocampal-dependent memory in rodents

21 June 2018

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Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.

21 June 2018

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Mouse models of cognitive disorders in trisomy 21: a review

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Transcriptional dysregulation in Down syndrome: predictions for altered protein complex stoichiometries and post-translational modifications, and consequences for learning/behavior genes ELK, CREB, and the estrogen and glucocorticoid receptors

21 June 2018

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Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice

21 June 2018

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An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes

21 June 2018

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Piracetam: a review of pharmacological properties and clinical uses.

21 June 2018

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Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome.

21 June 2018

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Cell proliferation is reduced in the dentate gyrus of aged but not young Ts65Dn mice, a model of Down syndrome

21 June 2018

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21 June 2018

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Clinical potential of minocycline for neurodegenerative disorders

21 June 2018

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On dendrites in Down syndrome and DS murine models: a spiny way to learn.

21 June 2018

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The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory

21 June 2018

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Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome.

21 June 2018

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SUMOylation regulates nucleo-cytoplasmic shuttling of Elk-1

21 June 2018

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Down's syndrome: a genetic disorder in biobehavioral perspective

21 June 2018

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App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome

21 June 2018

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Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia

21 June 2018

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The neuropsychology of Down syndrome: evidence for hippocampal dysfunction

21 June 2018

1 reference

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The specificities of protein kinase inhibitors: an update

21 June 2018

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Phosphorylation of hippocampal Erk-1/2, Elk-1, and p90-Rsk-1 during contextual fear conditioning: interactions between Erk-1/2 and Elk-1

21 June 2018

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Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion

21 June 2018

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The DNA sequence of human chromosome 21

21 June 2018

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Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

21 June 2018

1 reference

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Developmental abnormalities and age-related neurodegeneration in a mouse model of Down syndrome

21 June 2018

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Down syndrome phenotypes: the consequences of chromosomal imbalance

21 June 2018

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Enlarged brain ventricles and impaired neurogenesis in the Ts1Cje and Ts2Cje mouse models of Down syndrome

21 June 2018

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The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome.

30 October 2018

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Prenatal NAP+SAL prevents developmental delay in a mouse model of Down syndrome through effects on N-methyl-D-aspartic acid and gamma-aminobutyric acid receptors

30 October 2018

1 reference

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Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome

30 October 2018

1 reference

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Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome

30 October 2018

1 reference

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Promotion of neuronal plasticity by (-)-epigallocatechin-3-gallate

30 October 2018

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Acute injections of the NMDA receptor antagonist memantine rescue performance deficits of the Ts65Dn mouse model of Down syndrome on a fear conditioning test.

30 October 2018

1 reference

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Object recognition memory is conserved in Ts1Cje, a mouse model of Down syndrome

30 October 2018

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NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis.

30 October 2018

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Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities

30 October 2018

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Pharmacotherapy for cognitive impairment in a mouse model of Down syndrome.

30 October 2018

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Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

30 October 2018

1 reference

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Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome.

30 October 2018

1 reference

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Minocycline prevents cholinergic loss in a mouse model of Down's syndrome

30 October 2018

1 reference

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Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone

30 October 2018

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Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions

30 October 2018

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GVS-111 prevents oxidative damage and apoptosis in normal and Down's syndrome human cortical neurons.

30 October 2018

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The effects of piracetam on cognitive performance in a mouse model of Down's syndrome

30 October 2018

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In two species, females exhibit superior working memory and inferior reference memory on the water radial-arm maze.

30 October 2018

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Synaptic deficit in the temporal cortex of partial trisomy 16 (Ts65Dn) mice.

30 October 2018

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Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse.

30 October 2018

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Down syndrome and the genes of human chromosome 21: current knowledge and future potentials

30 October 2018

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The proteins of human chromosome 21.

30 October 2018

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12 December 2020

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Improved national prevalence estimates for 18 selected major birth defects--United States, 1999-2001

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Identifiers

DOI

10.1016/J.TIPS.2009.10.010

1 reference

28 July 2017

1 reference

28 July 2017

1 reference