High-throughput crystallization and structure determination in drug discovery. (Q30329499)

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6 December 2019

review article

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title

High-throughput crystallization and structure determination in drug discovery (English)

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6 December 2019

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3

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6 December 2019

author name string

Lance Stewart

series ordinal

1

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6 December 2019

Robin Clark

series ordinal

2

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6 December 2019

publication date

1 February 2002

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6 December 2019

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6 December 2019

volume

7

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6 December 2019

issue

3

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6 December 2019

page(s)

187-196

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The human genome project: a historical perspective

6 December 2019

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Proteomics as a tool in the pharmaceutical drug design process

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Virtual screening: an effective tool for lead structure discovery?

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Deciphering common failures in molecular docking of ligand-protein complexes.

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Mini-review: computational structure-based design of inhibitors that target protein surfaces

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7 January 2021

SPINE: an integrated tracking database and data mining approach for identifying feasible targets in high-throughput structural proteomics

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7 January 2021

The mammalian gene collection

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7 January 2021

dbEST--database for "expressed sequence tags"

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7 January 2021

Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis

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7 January 2021

Protein production: feeding the crystallographers and NMR spectroscopists

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7 January 2021

Current methods for manipulating baculoviruses

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7 January 2021

From genes to proteins: high-throughput expression and purification of the human proteome

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7 January 2021

Recombinant protein expression in Pichia pastoris

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7 January 2021

Cell-free production and stable-isotope labeling of milligram quantities of proteins

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7 January 2021

Purification of baculovirus-expressed recombinant Ras and Rap proteins

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7 January 2021

Large-scale purification of a stable form of recombinant tobacco etch virus protease

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7 January 2021

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

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7 January 2021

The importance of dynamic light scattering in obtaining multiple crystal forms of Trypanosoma brucei PGK.

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7 January 2021

Two-dimensional crystallization of membrane proteins.

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7 January 2021

Crystallization of membrane proteins in cubo.

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7 January 2021

Lipidic cubic phases: a novel concept for the crystallization of membrane proteins

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7 January 2021

Structure of bacteriorhodopsin at 1.55 A resolution

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7 January 2021

Structure of the light-driven chloride pump halorhodopsin at 1.8 A resolution

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7 January 2021

Crystal Structure of Sensory Rhodopsin II at 2.4 Angstroms: Insights into Color Tuning and Transducer Interaction

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7 January 2021

Structure of the photosynthetic reaction centre from Rhodobacter sphaeroides at 2.65 A resolution: cofactors and protein-cofactor interactions

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Structural basis of the drastically increased initial electron transfer rate in the reaction center from a Rhodopseudomonas viridis mutant described at 2.00-A resolution

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7 January 2021

The crystallographic structure of the B800-820 LH3 light-harvesting complex from the purple bacteria Rhodopseudomonas acidophila strain 7050

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7 January 2021

High-throughput x-ray crystallography for structure-based drug design

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7 January 2021

Discovering novel ligands for macromolecules using X-ray crystallographic screening

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7 January 2021

Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation

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7 January 2021

Crystal structures of substrates and products bound to the phosphoglycerate kinase active site reveal the catalytic mechanism

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7 January 2021

Automated crystal mounting and data collection for protein crystallography

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7 January 2021

AMoRe: an automated package for molecular replacement

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7 January 2021

Improved methods for building protein models in electron density maps and the location of errors in these models

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7 January 2021

TNT refinement package

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7 January 2021

WHAT IF: a molecular modeling and drug design program

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7 January 2021

10.1016/S1359-6446(01)02121-3

Identifiers

DOI

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6 December 2019

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