Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials (Q30251949)

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English	Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

Ebola Virus Infection: Review of the Pharmacokinetic and Pharmacodynamic Properties of Drugs Considered for Testing in Human Efficacy Trials (English)

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

Orthoebolavirus zairense

0 references

pharmacodynamics

1 reference

based on heuristic

inferred from title

pharmacokinetics

1 reference

based on heuristic

inferred from title

object named as

Jérémie Guedj

5

0 references

Xavier de Lamballerie

4

object named as

Xavier de Lamballerie

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

Anne-Marie Taburet

6

object named as

Anne-Marie Taburet

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

7

object named as

France Mentré

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

author name string

Vincent Madelain

1

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

Thi Huyen Tram Nguyen

2

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

Anaelle Olivo

3

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

publication date

1 August 2016

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

Clinical Pharmacokinetics

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

55

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

8

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

907-923

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

Clinical Implications of Antiviral Resistance in Influenza

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680399

20 June 2018

Ebola Virus Infection: Overview and Update on Prevention and Treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680399

20 June 2018

Ebola virus dynamics in mice treated with favipiravir

1 reference

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20 June 2018

The Use of Ebola Convalescent Plasma to Treat Ebola Virus Disease in Resource-Constrained Settings: A Perspective From the Field

1 reference

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20 June 2018

Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

1 reference

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20 June 2018

HCV Kinetic Models and Their Implications in Drug Development

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20 June 2018

Risk Factors Associated with Ebola and Marburg Viruses Seroprevalence in Blood Donors in the Republic of Congo

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20 June 2018

Persistence of Ebola Virus in Ocular Fluid during Convalescence

1 reference

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20 June 2018

The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States

1 reference

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20 June 2018

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates

1 reference

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20 June 2018

Inhibition of the tissue factor pathway of coagulation by recombinant nematode anticoagulant protein c2 during elective coronary stent implantation

1 reference

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20 June 2018

A single phosphorodiamidate morpholino oligomer targeting VP24 protects rhesus monkeys against lethal Ebola virus infection

1 reference

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20 June 2018

Emergency Ebola response: a new approach to the rapid design and development of vaccines against emerging diseases

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20 June 2018

Ebola virus disease.

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20 June 2018

Structures of protective antibodies reveal sites of vulnerability on Ebola virus

1 reference

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20 June 2018

Clinical illness and outcomes in patients with Ebola in Sierra Leone

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20 June 2018

Favipiravir elicits antiviral mutagenesis during virus replication in vivo

1 reference

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20 June 2018

Clinical features and pathobiology of Ebolavirus infection

1 reference

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20 June 2018

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp

1 reference

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20 June 2018

Caring for critically ill patients with ebola virus disease. Perspectives from West Africa.

1 reference

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20 June 2018

Interferons: Success in anti-viral immunotherapy

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20 June 2018

Safety and pharmacokinetic profiles of phosphorodiamidate morpholino oligomers with activity against ebola virus and marburg virus: results of two single-ascending-dose studies

1 reference

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20 June 2018

Viral kinetic modeling: state of the art

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20 June 2018

Phylogenetic Analysis of Guinea 2014 EBOV Ebolavirus Outbreak

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20 June 2018

The challenges of multiple organ dysfunction syndrome and extra-corporeal circuits for drug delivery in critically ill patients

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20 June 2018

Characterization of host immune responses in Ebola virus infections

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20 June 2018

Interferon beta assessment in non-Chinese and Chinese subjects: pharmacokinetics and pharmacodynamic activity of an endogenous cytokine are not race dependent

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20 June 2018

The clinically approved drugs amiodarone, dronedarone and verapamil inhibit filovirus cell entry

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20 June 2018

Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.

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20 June 2018

Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model

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20 June 2018

Post-exposure efficacy of oral T-705 (Favipiravir) against inhalational Ebola virus infection in a mouse model

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20 June 2018

Sustained protection against Ebola virus infection following treatment of infected nonhuman primates with ZMAb

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20 June 2018

mAbs and Ad-vectored IFN-α therapy rescue Ebola-infected nonhuman primates when administered after the detection of viremia and symptoms

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20 June 2018

Discussions and decisions of the 2012–2014 International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group, January 2012–June 2013.

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20 June 2018

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

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20 June 2018

Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail

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20 June 2018

Emerging targets and novel approaches to Ebola virus prophylaxis and treatment

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20 June 2018

Drug absorption, distribution, metabolism and excretion considerations in critically ill adults

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20 June 2018

Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection

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20 June 2018

Interferon-β therapy prolongs survival in rhesus macaque models of Ebola and Marburg hemorrhagic fever

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20 June 2018

Discovery and early development of AVI-7537 and AVI-7288 for the treatment of Ebola virus and Marburg virus infections

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20 June 2018

Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques

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20 June 2018

Identification and targeting of an interaction between a tyrosine motif within hepatitis C virus core protein and AP2M1 essential for viral assembly

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20 June 2018

Successful treatment of ebola virus-infected cynomolgus macaques with monoclonal antibodies

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20 June 2018

Nonhuman primates as models for the discovery and development of ebolavirus therapeutics

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20 June 2018

Pharmacology and therapeutic potential of interferons

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20 June 2018

Enhanced potency of a fucose-free monoclonal antibody being developed as an Ebola virus immunoprotectant

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20 June 2018

Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection

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20 June 2018

Identification of a small-molecule entry inhibitor for filoviruses

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20 June 2018

Ebola haemorrhagic fever

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20 June 2018

Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations

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20 June 2018

Advanced antisense therapies for postexposure protection against lethal filovirus infections.

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20 June 2018

Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

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20 June 2018

Antiviral activity of a small-molecule inhibitor of filovirus infection

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20 June 2018

A broad-spectrum antiviral targeting entry of enveloped viruses

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20 June 2018

FGI-104: a broad-spectrum small molecule inhibitor of viral infection

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20 June 2018

Evasion of interferon responses by Ebola and Marburg viruses

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20 June 2018

Development of a broad-spectrum antiviral with activity against Ebola virus

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20 June 2018

The promises and pitfalls of RNA-interference-based therapeutics

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20 June 2018

Potent in vitro activity of the albumin fusion type 1 interferons (albumin-interferon-alpha and albumin-interferon-beta) against RNA viral agents of bioterrorism and the severe acute respiratory syndrome (SARS) virus

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20 June 2018

Assessment of the risk of Ebola virus transmission from bodily fluids and fomites

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20 June 2018

Recombinant nematode anticoagulant protein c2 in patients with non-ST-segment elevation acute coronary syndrome: the ANTHEM-TIMI-32 trial

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20 June 2018

Human interferons alpha, beta and omega

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20 June 2018

Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys

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20 June 2018

Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event

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20 June 2018

Interferon in oncological practice: review of interferon biology, clinical applications, and toxicities

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20 June 2018

Human asymptomatic Ebola infection and strong inflammatory response

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20 June 2018

Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses

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20 June 2018

Anticoagulant repertoire of the hookworm Ancylostoma caninum

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20 June 2018

Ebola haemorrhagic fever in Zaire, 1976

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20 June 2018

Treatment of Ebola virus disease.

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21 January 2018

Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

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21 January 2018

Dose regimen of favipiravir for Ebola virus disease

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21 January 2018

Favipiravir for children with Ebola

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21 January 2018

Evaluation of immune globulin and recombinant interferon-alpha2b for treatment of experimental Ebola virus infections

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21 January 2018

Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement

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21 January 2018

Correction: Experimental Treatment with Favipiravir for Ebola Virus Disease (the JIKI Trial): A Historically Controlled, Single-Arm Proof-of-Concept Trial in Guinea

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680399

26 November 2018

Pharmacokinetics and anticoagulant properties of the factor VIIa-tissue factor inhibitor recombinant Nematode Anticoagulant Protein c2 following subcutaneous administration in man. Dependence on the stoichiometric binding to circulating factor X.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5680399

26 November 2018

Pharmacokinetics of interferon alpha-2b in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/26798032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recombinant nematode anticoagulant protein c2, an inhibitor of tissue factor/factor VIIa, attenuates coagulation and the interleukin-10 response in human endotoxemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26798032

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S40262-015-0364-1

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

15 June 2018

http://europepmc.org/abstract/PMC/5680399

ResearchGate publication ID

0 references

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