The RAF proteins take centre stage (Q29620153)

Europe PubMed Central

title

The RAF proteins take centre stage (English)

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30 April 2017

author name string

Wellbrock C

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1

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Karasarides M

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2

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Marais R

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3

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language of work or name

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30 April 2017

publication date

November 2004

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Nature Reviews Molecular Cell Biology

30 April 2017

published in

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volume

5

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issue

11

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page(s)

875-85

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Serine- and threonine-specific protein kinase activities of purified gag-mil and gag-raf proteins

30 April 2017

cites work

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Endothelial apoptosis in Braf-deficient mice

1 May 2017

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MEK kinase activity is not necessary for Raf-1 function

1 May 2017

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Mutations of the BRAF gene in human cancer

1 May 2017

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14-3-3 zeta negatively regulates raf-1 activity by interactions with the Raf-1 cysteine-rich domain

1 May 2017

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Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactions

1 May 2017

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Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

1 May 2017

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The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

1 May 2017

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Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

1 May 2017

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

1 May 2017

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A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity

1 May 2017

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Dynamic changes in C-Raf phosphorylation and 14-3-3 protein binding in response to growth factor stimulation: differential roles of 14-3-3 protein binding sites

1 May 2017

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Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1 May 2017

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Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak

1 May 2017

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Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1

1 May 2017

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S338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3

1 May 2017

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Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 May 2017

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Bcl-2 targets the protein kinase Raf-1 to mitochondria

1 May 2017

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Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1

1 May 2017

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Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism

1 May 2017

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Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis

1 May 2017

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Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

1 May 2017

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

1 May 2017

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Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

1 May 2017

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Murine Ksr interacts with MEK and inhibits Ras-induced transformation

1 May 2017

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Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf

1 May 2017

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Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus

1 May 2017

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Homologous cell-derived oncogenes in avian carcinoma virus MH2 and murine sarcoma virus 3611.

31 March 2020

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The mouse B-raf gene encodes multiple protein isoforms with tissue-specific expression.

31 March 2020

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Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene.

31 March 2020

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Craf-1 protein kinase is essential for mouse development.

31 March 2020

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Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

31 March 2020

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CI-1040 (PD184352), a targeted signal transduction inhibitor of MEK (MAPKK)

31 March 2020

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31 March 2020

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Ras proteins: different signals from different locations

31 March 2020

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Mitogenic signaling of Ras is regulated by differential interaction with Raf isozymes

31 March 2020

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14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation

31 March 2020

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Cyclic AMP-dependent kinase regulates Raf-1 kinase mainly by phosphorylation of serine 259.

31 March 2020

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14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity

31 March 2020

1 reference

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Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

31 March 2020

1 reference

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Negative regulation of Raf-1 by phosphorylation of serine 621.

31 March 2020

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Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

31 March 2020

1 reference

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Regulation of Ras·GTP Loading and Ras-Raf Association in Neonatal Rat Ventricular Myocytes by G Protein-coupled Receptor Agonists and Phorbol Ester

31 March 2020

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Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM1498

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation

31 March 2020

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Inhibition of the EGF-Activated MAP Kinase Signaling Pathway by Adenosine 3′,5′-Monophosphate

31 March 2020

1 reference

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Phosphorylation of serine 43 is not required for inhibition of c-Raf kinase by the cAMP-dependent protein kinase.

31 March 2020

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Cyclic AMP blocks cell growth through Raf-1-dependent and Raf-1-independent mechanisms

31 March 2020

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Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM1498

Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 Kinase

31 March 2020

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Functional mapping of the N-terminal regulatory domain in the human Raf-1 protein kinase

31 March 2020

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Phosphorylation site specificity of the Pak-mediated regulation of Raf-1 and cooperativity with Src.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM1498

Erythropoietin-stimulated Raf-1 tyrosine phosphorylation is associated with the tyrosine kinase Lyn in J2E erythroleukemic cells

31 March 2020

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Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM1498

Serine 338 phosphorylation is dispensable for activation of c-Raf1.

31 March 2020

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Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. insights into mechanisms of Raf-1 activation

31 March 2020

1 reference

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A phosphatidylinositol 3-kinase-dependent pathway that differentially regulates c-Raf and A-Raf

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM1498

Positive and negative regulation of Raf kinase activity and function by phosphorylation

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM1498

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM1498

Raf-1 protein kinase activates the NF-kappa B transcription factor by dissociating the cytoplasmic NF-kappa B-I kappa B complex

31 March 2020

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Characterization of IkappaB kinases. IkappaB-alpha is not phosphorylated by Raf-1 or protein kinase C isozymes, but is a casein kinase II substrate

31 March 2020

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Raf induces NF-kappaB by membrane shuttle kinase MEKK1, a signaling pathway critical for transformation

31 March 2020

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Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation

31 March 2020

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Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation

31 March 2020

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Raf and the road to cell survival: a tale of bad spells, ring bearers and detours

31 March 2020

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B-RAF is a therapeutic target in melanoma

31 March 2020

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The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras

31 March 2020

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Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf

31 March 2020

1 reference

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Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells

31 March 2020

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ERK signalling and oncogene transformation are not impaired in cells lacking A-Raf

31 March 2020

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Sustained activation of extracellular-signal-regulated kinase 1 (ERK1) is required for the continued expression of cyclin D1 in G1 phase

31 March 2020

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Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.

31 March 2020

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Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells

31 March 2020

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Different protein kinase C isoforms determine growth factor specificity in neuronal cells

31 March 2020

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Hypertrophic Agonists Stimulate the Activities of the Protein Kinases c-Raf and A-Raf in Cultured Ventricular Myocytes

31 March 2020

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Role of Raf in vascular protection from distinct apoptotic stimuli

31 March 2020

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Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

31 March 2020

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Critical contribution of linker proteins to Raf kinase activation

31 March 2020

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Structure and biological activity of human homologs of the raf/mil oncogene

31 March 2020

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Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human

31 March 2020

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The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus

31 March 2020

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B-raf, a new member of the raf family, is activated by DNA rearrangement

31 March 2020

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MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network

31 March 2020

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30 April 2017

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30 April 2017

Consolidated OpenCitations Corpus – April 2017