Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis (Q29416987)

16 April 2017

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Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis (English)

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genome-wide association study

16 April 2017

main subject

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chronic obstructive pulmonary disease

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4

Manuel Mattheisen

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Ruth Tal-Singer

23

object named as

Ruth Tal-Singer

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10

Nan M Laird

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Augusto A Litonjua

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John E Hokanson

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R Graham Barr

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ORCID Public Data File 2021

16 April 2017

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Merry-Lynn N McDonald

object named as

Merry-Lynn N McDonald

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ORCID Public Data File 2021

Edwin K Silverman

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object named as

Edwin K Silverman

1 reference

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Michael H Cho

1

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16 April 2017

Xiaobo Zhou

3

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Peter J Castaldi

5

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Craig P Hersh

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Dawn L Demeo

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Jody S Sylvia

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John Ziniti

9

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Christoph Lange

11

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David Sparrow

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Richard Casaburi

14

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Elizabeth A Regan

16

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Barry J Make

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Sharon Lutz

19

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Tanda Murray Dudenkov

20

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Homayoon Farzadegan

21

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Jacqueline B Hetmanski

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David A Lomas

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Per Bakke

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Amund Gulsvik

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James D Crapo

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Terri H Beaty

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16 April 2017

NETT Genetics, ICGN, ECLIPSE and COPDGene Investigators

30

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16 April 2017

publication date

7 February 2014

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The Lancet. Respiratory medicine

16 April 2017

published in

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16 April 2017

volume

2

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16 April 2017

issue

3

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16 April 2017

page(s)

214-225

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describes a project that uses

16 April 2017

genome-wide association study

1 reference

APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema

inferred from title

cites work

1 reference

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Genetic ancestry and the relationship of cigarette smoking to lung function and per cent emphysema in four race/ethnic groups: a cross-sectional study

18 April 2017

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Genome-wide association studies identify four ER negative-specific breast cancer risk loci

18 April 2017

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Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function

18 April 2017

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Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

18 April 2017

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An integrated map of genetic variation from 1,092 human genomes

18 April 2017

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Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production

18 April 2017

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MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

18 April 2017

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From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

18 April 2017

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Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia

18 April 2017

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Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

18 April 2017

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Genome-wide association study identifies five loci associated with lung function

18 April 2017

1 reference

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Common variants conferring risk of schizophrenia

18 April 2017

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Practical aspects of imputation-driven meta-analysis of genome-wide association studies

18 April 2017

1 reference

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Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

18 April 2017

1 reference

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PLINK: a tool set for whole-genome association and population-based linkage analyses

18 April 2017

1 reference

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Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

18 April 2017

1 reference

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

18 April 2017

1 reference

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Epithelial-derived TGF-beta2 modulates basal and wound-healing subepithelial matrix homeostasis

18 April 2017

1 reference

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A distinctive alveolar macrophage activation state induced by cigarette smoking

18 April 2017

1 reference

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Measuring inconsistency in meta-analyses

18 April 2017

1 reference

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A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema

18 April 2017

1 reference

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The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function

18 April 2017

1 reference

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A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5

18 April 2017

1 reference

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TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

18 April 2017

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METAL: fast and efficient meta-analysis of genomewide association scans

18 April 2017

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Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary

18 April 2017

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Fast and accurate genotype imputation in genome-wide association studies through pre-phasing

18 April 2017

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LocusZoom: regional visualization of genome-wide association scan results

18 April 2017

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International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study

18 April 2017

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Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies

18 April 2017

1 reference

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Deaths: preliminary data for 2008.

18 April 2017

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GOLD 2011 disease severity classification in COPDGene: a prospective cohort study

3 June 2018

1 reference

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Distilling pathophysiology from complex disease genetics

3 June 2018

1 reference

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Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms

3 June 2018

1 reference

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Heritability of chronic obstructive pulmonary disease and related phenotypes in smokers

3 June 2018

1 reference

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Refining susceptibility loci of chronic obstructive pulmonary disease with lung eqtls

3 June 2018

1 reference

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Bringing genome-wide association findings into clinical use.

3 June 2018

1 reference

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FAM13A locus in COPD is independently associated with lung cancer - evidence of a molecular genetic link between COPD and lung cancer

3 June 2018

1 reference

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Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations

3 June 2018

1 reference

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Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained

3 June 2018

1 reference

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Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells

3 June 2018

1 reference

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Lung eQTLs to help reveal the molecular underpinnings of asthma

3 June 2018

1 reference

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Large-scale association analysis identifies new risk loci for coronary artery disease

3 June 2018

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RIN3 is a negative regulator of mast cell responses to SCF.

3 June 2018

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Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population

3 June 2018

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Common variants at 6p21.1 are associated with large artery atherosclerotic stroke

3 June 2018

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Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction

3 June 2018

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TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome

3 June 2018

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Emerging roles for cholesterol and lipoproteins in lung disease

3 June 2018

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CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland

3 June 2018

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Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6.

3 June 2018

1 reference

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Interpreting meta-analyses of genome-wide association studies

3 June 2018

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Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP.

3 June 2018

1 reference

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A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13.

3 June 2018

1 reference

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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function.

3 June 2018

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TGF-β2 reduces nitric oxide synthase mRNA through a ROCK-dependent pathway in airway epithelial cells

3 June 2018

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Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies

3 June 2018

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Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study

3 June 2018

1 reference

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Innate immune responses are increased in chronic obstructive pulmonary disease

3 June 2018

1 reference

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3 June 2018

1 reference

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Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups

3 June 2018

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A versatile gene-based test for genome-wide association studies

3 June 2018

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Interpretation of association signals and identification of causal variants from genome-wide association studies

3 June 2018

1 reference

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Tgf-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma

3 June 2018

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Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation

3 June 2018

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Genetic epidemiology of COPD (COPDGene) study design

3 June 2018

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Variants in FAM13A are associated with chronic obstructive pulmonary disease

3 June 2018

1 reference

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Association of MMP-2 polymorphisms with severe and very severe COPD: a case control study of MMPs-1, 9 and 12 in a European population

3 June 2018

1 reference

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MMP12, lung function, and COPD in high-risk populations

3 June 2018

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Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study

3 June 2018

1 reference

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Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene

3 June 2018

1 reference

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Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions

3 June 2018

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Clinical practice. Alpha1-antitrypsin deficiency

3 June 2018

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A genome-wide association study of pulmonary function measures in the Framingham Heart Study

3 June 2018

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A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.

3 June 2018

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Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease

3 June 2018

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COPD: racial disparities in susceptibility, treatment, and outcomes

3 June 2018

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Genetic association analysis of functional impairment in chronic obstructive pulmonary disease

3 June 2018

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A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease

3 June 2018

1 reference

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Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma.

3 June 2018

1 reference

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RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway

3 June 2018

1 reference

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Oncostatin M induced alpha1-antitrypsin (AAT) gene expression in Hep G2 cells is mediated by a 3' enhancer

3 June 2018

1 reference

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Interleukin-4- and interleukin-13-enhanced transforming growth factor-beta2 production in cultured human bronchial epithelial cells is attenuated by interferon-gamma

3 June 2018

1 reference

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Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis.

3 June 2018

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Functional status and well being in chronic obstructive pulmonary disease with regard to clinical parameters and smoking: a descriptive and comparative study

3 June 2018

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Quantitative relationships between cigarette smoking and ventilatory function

3 June 2018

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Using phenotypic heterogeneity to increase the power of genome-wide association studies: application to age at onset of ischaemic stroke subphenotypes.

3 June 2018

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Sputum matrix metalloproteinase-12 in patients with chronic obstructive pulmonary disease and asthma: relationship to disease severity.

26 November 2018

1 reference

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Genetic influences on Chronic Obstructive Pulmonary Disease - a twin study

26 November 2018

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Lung cancer gene associated with COPD: triple whammy or possible confounding effect?

26 November 2018

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COPD and declining FEV1--time to divide and conquer?

26 November 2018

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Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.

26 November 2018

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Computed tomographic-based quantification of emphysema and correlation to pulmonary function and mechanics.

26 November 2018

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The SERPINE2 gene is associated with chronic obstructive pulmonary disease in two large populations.

26 November 2018

1 reference

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Increased TGF-beta2 in severe asthma with eosinophilia

26 November 2018

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The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD).

26 November 2018

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Lipids and pulmonary function in the Third National Health and Nutrition Examination Survey.

26 November 2018

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Allele-specific regulation of matrix metalloproteinase-12 gene activity is associated with coronary artery luminal dimensions in diabetic patients with manifest coronary artery disease

26 November 2018

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Siblings of patients with severe chronic obstructive pulmonary disease have a significant risk of airflow obstruction

26 November 2018

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7 January 2021

Chromosome 4q31 locus in COPD is also associated with lung cancer

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7 January 2021

Prognosis in chronic obstructive pulmonary disease

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7 January 2021

Extreme discordant sib pairs for mapping quantitative trait loci in humans

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7 January 2021

Mast cell infiltration discriminates between histopathological phenotypes of chronic obstructive pulmonary disease

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7 January 2021

Alterations in lung mast cell populations in patients with chronic obstructive pulmonary disease

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7 January 2021

Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice

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7 January 2021

Lipoprotein(a) serum levels in patients affected by chronic obstructive pulmonary disease

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7 January 2021

10.1016/S2213-2600(14)70002-5

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DOI

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