A Novel Mitogenic Signaling Pathway of Bradykinin in the Human Colon Carcinoma Cell Line SW-480 Involves Sequential Activation of a Gq/11 Protein, Phosphatidylinositol 3-Kinase , and Protein Kinase C (Q29037561)

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scientific article (publication date: 27 November 1998)

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English	A Novel Mitogenic Signaling Pathway of Bradykinin in the Human Colon Carcinoma Cell Line SW-480 Involves Sequential Activation of a Gq/11 Protein, Phosphatidylinositol 3-Kinase , and Protein Kinase C	scientific article (publication date: 27 November 1998)

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A Novel Mitogenic Signaling Pathway of Bradykinin in the Human Colon Carcinoma Cell Line SW-480 Involves Sequential Activation of a Gq/11 Protein, Phosphatidylinositol 3-Kinase , and Protein Kinase C (English)

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27 March 2017

colon carcinoma

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A. Graness

1

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A. Adomeit

2

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R. Heinze

3

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R. Wetzker

4

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C. Liebmann

5

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publication date

27 November 1998

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Journal of Biological Chemistry

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273

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48

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32016-32022

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The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades

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Bombesin, bradykinin, vasopressin, and phorbol esters rapidly and transiently activate Src family tyrosine kinases in Swiss 3T3 cells. Dissociation from tyrosine phosphorylation of p125 focal adhesion kinase

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PI3K: downstream AKTion blocks apoptosis

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The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

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21 January 2018

Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit.

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21 January 2018

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

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21 January 2018

Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Dual bradykinin B2 receptor signalling in A431 human epidermoid carcinoma cells: activation of protein kinase C is counteracted by a GS-mediated stimulation of the cyclic AMP pathway

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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Biochemical and Molecular Pharmacology of Kinin Receptors

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The identification of an orally active, nonpeptide bradykinin B2 receptor antagonist, FR173657

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PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

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Novel bradykinin signalling events in PC-12 cells: stimulation of the cAMP pathway leads to cAMP-mediated translocation of protein kinase Cepsilon

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Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells

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21 January 2018

Bradykinin induces translocation of the protein kinase C isoforms alpha, epsilon, and zeta

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G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits

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Tyrosine phosphorylation of GSalpha and inhibition of bradykinin-induced activation of the cyclic AMP pathway in A431 cells by epidermal growth factor receptor

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Platelet-derived growth factor activates protein kinase C epsilon through redundant and independent signaling pathways involving phospholipase C gamma or phosphatidylinositol 3-kinase

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Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase

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Protein kinase C delta specifically associates with phosphatidylinositol 3-kinase following cytokine stimulation

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10.1074/JBC.273.48.32016

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