Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation (Q28379485)

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English	Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation	scientific article

Statements

scholarly article

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Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation (English)

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1 reference

based on heuristic

inferred from title

apoptotic process

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based on heuristic

inferred from title

1 reference

ORCID Public Data File 2021

author name string

D M Pritchard

1

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A J Watson

2

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C S Potten

3

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A L Jackman

4

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J A Hickman

5

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language of work or name

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publication date

4 March 1997

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Proceedings of the National Academy of Sciences of the United States of America

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94

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5

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1795-9

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The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

20 March 2017

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

7 April 2017

Cancer. p53, guardian of the genome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

7 April 2017

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

7 April 2017

The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

29 September 2017

ZD1694 (Tomudex): A new thymidylate synthase inhibitor with activity in colorectal cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

29 September 2017

Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

29 September 2017

Further studies on the response of intestinal crypt cells of different hierarchical status to eighteen different cytotoxic agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

29 September 2017

Enhancement of the antitumor activity of 5-fluorouracil by uridine rescue

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

29 September 2017

Metabolism and mechanism of action of 5-fluorouracil

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

29 September 2017

The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

29 September 2017

Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

29 September 2017

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

2 June 2018

Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

2 June 2018

Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

2 June 2018

Target cells for the cytotoxic effects of carcinogens in the murine small bowel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

2 June 2018

p53 is covalently linked to 5.8S rRNA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=19996

2 June 2018

Differential expression of bcl-2 in intestinal epithelia. Correlation with attenuation of apoptosis in colonic crypts and the incidence of colonic neoplasia

1 reference

https://pubmed.ncbi.nlm.nih.gov/9050858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE EFFECT OF FIVE-FLUOROURACIL ON RECTAL MUCOSA

1 reference

https://pubmed.ncbi.nlm.nih.gov/9050858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biochemical consequences of 5-fluorouracil gastrointestinal toxicity in rats; effect of high-dose uridine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9050858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of uridine treatment in mice on the protection of gastrointestinal toxicity caused by 5-fluorouracil

1 reference

https://pubmed.ncbi.nlm.nih.gov/9050858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

U.v.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/9050858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhanced cytotoxicity with interleukin-1 alpha and 5-fluorouracil in HCT116 colon cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9050858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-dose 5-fluorouracil with delayed uridine "rescue" in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9050858

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.94.5.1795

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1997PNAS...94.1795P

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PubMed publication ID

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