Drug targeting to the brain (Q28305371)

Blood-brain barrier: interface between internal medicine and the brain

Europe PubMed Central

title

Drug targeting to the brain (English)

0 references

0 references

William M Pardridge

1

0 references

language of work or name

English

0 references

publication date

September 2007

0 references

published in

Pharmaceutical Research

0 references

volume

24

0 references

issue

9

0 references

page(s)

1733-44

0 references

cites work

1 reference

https://api.crossref.org/works/10.1007%2FS11095-007-9324-2

The Transport of a Drug to the Cerebrospinal Fluid Directly from the Nasal Cavity: The Relation to the Lipophilicity of the Drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-007-9324-2

Direct access of drugs to the human brain after intranasal drug administration?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-007-9324-2

Neuroprotection in transient focal brain ischemia after delayed intravenous administration of brain-derived neurotrophic factor conjugated to a blood-brain barrier drug targeting system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11095-007-9324-2

Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Structural changes in the rat brain after carotid infusions of hyperosmolar solutions. An electron microscopic study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Drug targeting of a peptide radiopharmaceutical through the primate blood-brain barrier in vivo with a monoclonal antibody to the human insulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Blood-brain barrier delivery

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Conjugation of brain-derived neurotrophic factor to a blood-brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Imaging brain tumors by targeting peptide radiopharmaceuticals through the blood-brain barrier.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Liposome-mediated, nonviral gene transfer induces a systemic inflammatory response which can exacerbate pre-existing inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Blood-brain barrier transcytosis of insulin in developing rabbits

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

The blood-brain barrier efflux transporters as a detoxifying system for the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Functional heterodimeric amino acid transporters lacking cysteine residues involved in disulfide bond

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Absence of toxicity of chronic weekly intravenous gene therapy with pegylated immunoliposomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Comparison of nonelectrolyte permeability patterns in several epithelia

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Site-directed mutagenesis of cysteine residues of large neutral amino acid transporter LAT1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Organ-specific expression of the lacZ gene controlled by the opsin promoter after intravenous gene administration in adult mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Cerebral circulatory and metabolic effects of vasoactive intestinal polypeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Diffusion of Small Non-Electrolytes across Liposome Membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

The role of organ vascularization and lipoplex-serum initial contact in intravenous murine lipofection

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Blood-brain barrier permeation: molecular parameters governing passive diffusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Non-Stokesian nature of transverse diffusion within human red cell membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Chemotherapeutic drugs released from polymers: distribution of 1,3-bis(2-chloroethyl)-1-nitrosourea in the rat brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Mediated efflux of IgG molecules from brain to blood across the blood-brain barrier.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Human insulin receptor monoclonal antibody undergoes high affinity binding to human brain capillaries in vitro and rapid transcytosis through the blood-brain barrier in vivo in the primate

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Expression of the neonatal Fc receptor (FcRn) at the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Epidermal growth factor radiopharmaceuticals: 111In chelation, conjugation to a blood-brain barrier delivery vector via a biotin-polyethylene linker, pharmacokinetics, and in vivo imaging of experimental brain tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Efflux of radiolabeled polyethylene glycols and albumin from rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Drainage of interstitial fluid from different regions of rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Antisense gene therapy of brain cancer with an artificial virus gene delivery system

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Brain metabolism: a perspective from the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Studies of the blood-cerebrospinal fluid barrier to cortisol in the dog.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Intraputamenal infusion of GDNF in aged rhesus monkeys: Distribution and dopaminergic effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Efflux transport systems for drugs at the blood-brain barrier and blood-cerebrospinal fluid barrier (Part 1).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1-40 through the blood-brain barrier and binding to Alzheimer disease amyloid of the A beta 1-40/vector complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Selective transport of an anti-transferrin receptor antibody through the blood-brain barrier in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Brain-specific expression of an exogenous gene after i.v. administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Imaging gene expression in regional brain ischemia in vivo with a targeted [111in]-antisense radiopharmaceutical

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Enhanced neuroprotective effects of basic fibroblast growth factor in regional brain ischemia after conjugation to a blood-brain barrier delivery vector

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

[Infiltration of India ink from subarachnoid space to nasal mucosa along olfactory nerves in rabbits]

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Global non-viral gene transfer to the primate brain following intravenous administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Imaging endogenous gene expression in brain cancer in vivo with 111In-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Noninvasive gene targeting to the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Distribution of nerve growth factor following direct delivery to brain interstitium

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Pharmacokinetics of chlorambucil-tertiary butyl ester, a lipophilic chlorambucil derivative that achieves and maintains high concentrations in brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Modification of the blood-brain barrier in the chemotherapy of malignant brain tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Uptake of melatonin into the cerebrospinal fluid after nasal and intravenous delivery: studies in rats and comparison with a human study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Cloned blood-brain barrier adenosine transporter is identical to the rat concentrative Na+ nucleoside cotransporter CNT2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

The role of insulin-like growth factor binding proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Quantitative evaluation of blood-brain barrier permeability following middle cerebral artery occlusion in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Central nervous system pharmacologic effect in conscious rats after intravenous injection of a biotinylated vasoactive intestinal peptide analog coupled to a blood-brain barrier drug delivery system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Recent advances in blood-brain barrier transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Localization of vasoactive intestinal polypeptide (VIP) to central and peripheral neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

A study of intrathecal, cerebrospinal fluid-to-brain exchange

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Unusual topography of bovine rhodopsin promoter-lacZ fusion gene expression in transgenic mouse retinas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Expression cloning and characterization of a transporter for large neutral amino acids activated by the heavy chain of 4F2 antigen (CD98)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Site-directed mutagenesis of rabbit LAT1 at amino acids 219 and 234.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Pharmacokinetics of progesterone after its administration to ovariectomized rhesus monkeys by injection, infusion, or nasal spraying

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Scanning and transmission electron microscopic studies of microvascular pathology in the osmotically impaired blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Evidence for a 'paravascular' fluid circulation in the mammalian central nervous system, provided by the rapid distribution of tracer protein throughout the brain from the subarachnoid space

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Carrier-mediated or specialized transport of drugs across the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Neuroprotection with noninvasive neurotrophin delivery to the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Glut1 glucose transporter activity in human brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Delivery of beta-galactosidase to mouse brain via the blood-brain barrier transferrin receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Drug-like properties and the causes of poor solubility and poor permeability

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020

Blood-brain barrier transport and brain metabolism of adenosine and adenosine analogs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17554607

12 December 2020