Interconvertible lac repressor-DNA loops revealed by single-molecule experiments (Q28295676)

1

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Martin Guthold

2

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Dorothy A Erie

3

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Jeff Gelles

Creative Commons Attribution 4.0 International

4

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language of work or name

English

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publication date

30 September 2008

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published in

PLOS Biology

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volume

6

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issue

9

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page(s)

e232

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copyright license

start time

30 September 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Single-molecule manipulation reveals supercoiling-dependent modulation of lac repressor-mediated DNA looping

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Effects of nucleoid proteins on DNA repression loop formation in Escherichia coli

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Analysis of in-vivo LacR-mediated gene repression based on the mechanics of DNA looping

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Viewing single lambda site-specific recombination events from start to finish

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Lac repressor hinge flexibility and DNA looping: single molecule kinetics by tethered particle motion

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Modeling the Lac repressor-operator assembly: the influence of DNA looping on Lac repressor conformation

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Stepwise bending of DNA by a single TATA-box binding protein.

29 September 2017

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Statistical-mechanical theory of DNA looping.

29 September 2017

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DNA looping-mediated repression by histone-like protein H-NS: specific requirement of Esigma70 as a cofactor for looping

29 September 2017

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Single-molecule spectroscopic determination of lac repressor-DNA loop conformation

29 September 2017

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A gamut of loops: meandering DNA.

29 September 2017

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Structural dynamics of the lac repressor-DNA complex revealed by a multiscale simulation

29 September 2017

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Cyclization of short DNA fragments and bending fluctuations of the double helix

29 September 2017

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Exact theory of kinkable elastic polymers.

29 September 2017

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DNA twisting flexibility and the formation of sharply looped protein-DNA complexes

29 September 2017

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Atomic force microscopic analysis of the binding of the Schizosaccharomyces pombe origin recognition complex and the spOrc4 protein with origin DNA.

29 September 2017

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DNA trajectory in the Gal repressosome

29 September 2017

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Supercoiling and denaturation in Gal repressor/heat unstable nucleoid protein (HU)-mediated DNA looping

29 September 2017

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Structural transitions and elasticity from torque measurements on DNA.

29 September 2017

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Fluorescence resonance energy transfer over approximately 130 basepairs in hyperstable lac repressor-DNA loops

29 September 2017

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Some repressors of bacterial transcription

29 September 2017

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Lactose repressor protein: functional properties and structure.

29 September 2017

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DNA looping by Ku and the DNA-dependent protein kinase

29 September 2017

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Atomic force microscopic demonstration of DNA looping by GalR and HU.

29 September 2017

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Scanning force microscopy of DNA deposited onto mica: equilibration versus kinetic trapping studied by statistical polymer chain analysis.

29 September 2017

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Estimating single-channel kinetic parameters from idealized patch-clamp data containing missed events

29 September 2017

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Action at a distance: DNA-looping and initiation of transcription

29 September 2017

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Modulation of the stability of a Lac repressor mediated looped complex by temperature and ions: allosteric regulation by chloride

29 September 2017

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Transcription regulation by inflexibility of promoter DNA in a looped complex

29 September 2017

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Double helical DNA: conformations, physical properties, and interactions with ligands

29 September 2017

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Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair

29 September 2017

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The locus of sequence-directed and protein-induced DNA bending

29 September 2017

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An operator at -280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression

29 September 2017

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The lac Repressor Protein: Molecular Shape, Subunit Structure, and Proposed Model for Operator Interaction Based on Structural Studies of Microcrystals

29 September 2017

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lac repressor forms loops with linear DNA carrying two suitably spaced lac operators

29 September 2017

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Interaction of spatially separated protein-DNA complexes for control of gene expression: operator conversions

29 September 2017

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In vivo DNA loops in araCBAD: size limits and helical repeat

29 September 2017

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The three operators of the lac operon cooperate in repression

29 September 2017

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Transcription by single molecules of RNA polymerase observed by light microscopy

29 September 2017

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In vitro repression of the gal promoters by GalR and HU depends on the proper helical phasing of the two operators

29 September 2017

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Wrapping of DNA around the E.coli RNA polymerase open promoter complex

2 June 2018

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Transcriptional activation via DNA-looping: visualization of intermediates in the activation pathway of E. coli RNA polymerase x sigma 54 holoenzyme by scanning force microscopy.

2 June 2018

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On the stochastic properties of single ion channels

2 June 2018

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Cooperative binding of lambda repressors to sites separated by integral turns of the DNA helix

2 June 2018

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DNA loops induced by cooperative binding of lambda repressor

2 June 2018

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Upstream operators enhance repression of the lac promoter

2 June 2018

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Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter

2 June 2018

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DNA looping and unlooping by AraC protein

2 June 2018

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Stability of a Lac repressor mediated "looped complex".

2 June 2018

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Bacterial repression loops require enhanced DNA flexibility.

2 June 2018

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27 November 2018

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Nucleotide binding to DNA gyrase causes loss of DNA wrap

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Structural basis for cooperative DNA binding by CAP and lac repressor.

27 November 2018

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27 November 2018

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Repression of lac promoter as a function of distance, phase and quality of an auxiliary lac operator

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12 December 2020

Integration host factor alters LacI-induced DNA looping

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Escherichia coli lac repressor is elongated with its operator DNA binding domains located at both ends

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Conformation of Lac repressor tetramer in solution, bound and unbound to operator DNA

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Wrapping of flanking non-operator DNA in lac repressor-operator complexes: implications for DNA looping

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Measurement of lactose repressor-mediated loop formation and breakdown in single DNA molecules

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Designed hyperstable Lac repressor.DNA loop topologies suggest alternative loop geometries

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12 December 2020

Localized single-stranded bubble mechanism for cyclization of short double helix DNA

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12 December 2020

lac repressor forms stable loops in vitro with supercoiled wild-type lac DNA containing all three natural lac operators

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12 December 2020

DNA bend direction by phase sensitive detection

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12 December 2020