A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor (Q28288514)

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W Yonemoto

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S Ferrell

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D Williams-Herman

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R Geleziunas

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W C Greene

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

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language of work or name

English

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publication date

5 November 1998

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published in

Current Biology

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volume

8

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issue

22

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page(s)

1235-8

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cites work

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Human immunodeficiency virus type 1 Nef induces accumulation of CD4 in early endosomes

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The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane

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Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

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Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

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Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

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Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

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The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

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Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo

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A Role for Acidic Residues in Di-leucine Motif-based Targeting to the Endocytic Pathway

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Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain

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HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization

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Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

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Nef-mediated clathrin-coated pit formation

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Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

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The trans-Golgi network: a late secretory sorting station

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Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.

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Inhibition of Nef- and phorbol ester-induced CD4 degradation by macrolide antibiotics.

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Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.

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The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

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HIV accessory proteins: leading roles for the supporting cast.

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Nef proteins encoded by human and simian immunodeficiency viruses induce the accumulation of endosomes and lysosomes in human T cells

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Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

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