FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis (Q28288357)

Expert Opinion on Investigational Drugs

Europe PubMed Central

title

FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis (English)

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Thomas Baumruker

1

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Andreas Billich

series ordinal

2

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Volker Brinkmann

series ordinal

3

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language of work or name

English

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publication date

March 2007

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published in

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volume

16

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issue

3

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page(s)

283-9

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cites work

Essential role for sphingosine kinases in neural and vascular development

1 reference

https://api.crossref.org/works/10.1517/13543784.16.3.283

Sphingosine-1-phosphate: an enigmatic signalling lipid

20 April 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

20 April 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

20 April 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

The identification of myriocin-binding proteins

20 April 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Sphingosine-1-phosphate in cell growth and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Physiological and pathological actions of sphingosine 1-phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

The role of sphingosine and ceramide kinases in inflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

The immune modulator FTY720 targets sphingosine 1-phosphate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Pulmonary and vascular pharmacology of sphingosine 1-phosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

CD69 acts downstream of interferon-alpha/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Phosphorylation and action of the immunomodulator FTY720 inhibits vascular endothelial cell growth factor-induced vascular permeability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Physiologically based pharmacokinetic modeling of FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in rats after oral and intravenous doses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Predictability of FTY720 efficacy in experimental autoimmune encephalomyelitis by in vivo macrophage tracking: clinical implications for ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Oral fingolimod (FTY720) for relapsing multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Molecular and cellular diversity of neuronal G-protein-gated potassium channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Effects of sphingosine 1-phosphate on pacemaker activity in rabbit sino-atrial node cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Activation of muscarinic K+ current in guinea-pig atrial myocytes by sphingosine-1-phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Heartfelt crosstalk: desensitization of the GIRK current

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

FTY720 immunosuppression impairs effector T cell peripheral homing without affecting induction, expansion, and memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

CD8 T-cell memory: the other half of the story

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

FTY720 alters lymphocyte homing and protects allografts without inducing general immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Design, synthesis, and structure-activity relationships of 2-substituted-2-amino-1,3-propanediols: Discovery of a novel immunosuppressant, FTY720

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283

Transactivation of Sphingosine 1-Phosphate Receptors Is Essential for Vascular Barrier Regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.16.3.283