Pharmacokinetics and pharmacodynamics of estramustine phosphate (Q28265562)

Clinical Pharmacokinetics

Europe PubMed Central

title

Pharmacokinetics and pharmacodynamics of estramustine phosphate (English)

0 references

1 reference

1 reference

A T Bergenheim

1

0 references

R Henriksson

series ordinal

2

0 references

language of work or name

English

0 references

publication date

February 1998

0 references

published in

0 references

volume

34

0 references

issue

2

0 references

page(s)

163-72

0 references

cites work

Uptake, metabolism and antiproliferative effect of estramustine phosphate in human glioma cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

The effects of estramustine on metaphase and anaphase in DU 145 prostatic carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Pharmacokinetics of estramustine phosphate (Estracyt) in prostatic cancer patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine phosphate--historical overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine binding protein and anti-proliferative effect of estramustine in human glioma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Nuclear protein matrix as a target for estramustine-induced cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Inhibition of prostate cancer growth by estramustine and etoposide: evidence for interaction at the nuclear matrix

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine-induced mitotic arrest in two human prostatic carcinoma cell lines DU 145 and PC-3

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Growth and cell survival following treatment with estramustine nor-nitrogen mustard, estradiol and testosterone of a human prostatic cancer cell line (DU 145)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Changes in blood coagulation and fibrinolysis in patients on different treatment regimens for prostatic cancer. Predictors for cardiovascular complications?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Purification and distribution of a major protein in rat prostate that binds estramustine, a nitrogen mustard derivative of estradiol-17 beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

The interaction of steroidal alkylating agents with binding components in the soluble fraction of the prostate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

[Clinical trial of estradiol phenol bis (2-chloroethyl) carbamate in advanced breast cancer]

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Clinical toxicity and long-term results of Emcyt therapy for prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Effect of treatment on the expression of estramustine-binding protein (EMBP) in prostatic cancer patients: an immunohistochemical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Treatment of Prostatic Carcinoma with Various Types of Estrogen Derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Partial characterization and "quantitation" of a human prostatic estramustine-binding protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Effects of estramustine and its constituents on human malignant glioma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

An immunohistochemical technique for localization and semiquantitation of estramustine-binding protein (EMBP) in rat and human prostate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine phosphate inhibits microtubule assembly by binding to the microtubule-associated proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Expression of estramustine-binding protein in ependymomas and in human and developing rat ependymal cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Evidence for a non-estrogenic cytostatic effect of estramustine on human prostatic carcinoma cells in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Selective antimitotic effects of estramustine correlate with its antimicrotubule properties on glioblastoma and astrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine binding protein in human brain-tumor tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Effect of oral estramustine phosphate on pituitary, gonadal, and adrenal function in the green monkey (Cercopithecus aethiops sabaeus)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine inhibits monocyte phagocytosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Prostatic Binding Protein. A Steroid-Binding Protein Secreted by Rat Prostate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Impairment of estramustine phosphate absorption by concurrent intake of milk and food

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Uptake and retention of estramustine and the presence of estramustine binding protein in malignant brain tumours in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Prostate alpha-protein. Isolation and characterization of the polypeptide components and cholesterol binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Treatment of Advanced Prostatic Carcinoma with Estramustine Phosphate (Estracyt®)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Purification and characterisation of prostatic binding protein and its subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Plasma Concentrations of Estramustine Phosphate and Its Major Metabolites in Patients with Prostatic Carcinoma Treated with Different Doses of Estramustine Phosphate (Estracyt®)

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine-phosphate binds to a tubulin binding domain on microtubule-associated proteins MAP-2 and tau.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Metabolism of estramustine phosphate (Estracyt) in patients with prostatic carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Early morphological detection of estramustine cytotoxicity measured as alteration in cell size and shape by a new technique of microperifusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine binding protein in primary tumours and metastases of malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine potentiates the effects of irradiation on the Dunning (R3327) rat prostatic adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Studies with tritium-labelled hexoestrol in advanced breast cancer. Comparison of tissue accumulation of hexoestrol with response to bilateral adrenalectomy and oophorectomy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine binds MAP-2 to inhibit microtubule assembly in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Binding of estramustine, a nitrogen mustard derivative of estradiol-17 beta, in cytosol from rat ventral prostate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

In vitro binding of tritiated hormone-cytostatic complexes in the cytosol of various rat tissues and the incorporation of these complexes into nuclei

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Identification of potassium flux pathways and their role in the cytotoxicity of estramustine in human malignant glioma, prostatic carcinoma and pulmonary carcinoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Cytotoxic properties of estramustine unrelated to alkylating and steroid constituents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Biochemical assays for the selection of cytotoxic-linked estrogens with potential therapeutic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Accumulation of estramustine and estromustine in adipose tissue of rats and humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

X-ray sensitivity during the cell generation cycle of cultured Chinese hamster cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine-binding protein--a marker for effect of therapy in prostatic carcinoma?

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

DNA fragmentation induced by the antimitotic drug estramustine in malignant rat glioma but not in normal brain--suggesting an apoptotic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Expression and partial characterization of estramustine-binding protein (EMBP) in human breast cancer and malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Hormone-independent, non-alkylating mechanism of cytotoxicity for estramustine

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Apoptotic tumor cell death induced by estramustine in patients with malignant glioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Uptake of estramustine phosphate (estracyt) metabolites in prostatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Treatment of Rapidly Progressing Prostatic Carcinoma with Estracyt

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Cytotoxic effect and uptake of estramustine in a rat glioma model

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Tumor blood flow and the cytotoxic effects of estramustine and its constituents in a rat glioma model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

The absorption metabolism, and excretion of Estracyt (NSC 89199) in patients with prostatic cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Prognostic implication of estramustine-binding protein in astrocytoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

The effect of oxygen on cellular survival and recovery after radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine sensitizes human glioblastoma cells to irradiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Binding characteristics of a major protein in rat ventral prostate cytosol that interacts with estramustine, a nitrogen mustard derivative of 17 beta-estradiol

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Cross-resistance of nocodazole-resistant mutants of CHO cells toward other microtubule inhibitors: similar mode of action of benzimidazole carbamate derivatives and NSC 181928 and TN-16

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine and estrone analogs rapidly and reversibly inhibit deoxyribonucleic acid synthesis and alter morphology in cultured human glioblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

The effect of estramustine on microtubuli is different from the direct action via oxygen radicals on DNA and cell membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Radiosensitizing effect of estramustine in malignant glioma in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

[Treatment with estramustine phosphate in advanced prostatic cancer]

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine phosphate: plasma concentrations of its metabolites following oral administration to man, rat and dog

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Specific binding of estramustine to prostatic proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Effect of estramustine phosphate on plasma testosterone during treatment of carcinoma of prostate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Antimicrotubule effects of estramustine, an antiprostatic tumor drug.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Studies on phenolic steroids in human subjects. XIV. Fate of a nitrogen mustard of estradiol-17beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine-binding protein and specific binding of the anti-mitotic compound estramustine in astrocytoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine depolymerizes microtubules by binding to tubulin

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Expression of an estramustine-binding associated protein in human lung cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Effects of estramustine on DNA and cell membrane in malignant glioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Radiation sensitization by estramustine studies on cultured human prostatic cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine binding protein (EMBP) in rat R3327 Dunning tumors: partial characterization and effect of hormonal withdrawal, hormonal replacement, and cytotoxic treatment on its expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Preclinical pharmacology and toxicology of estramustine phosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020

Estramustine phosphate in the treatment of advanced prostatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/9515186

12 December 2020