RUNX1/AML1: a central player in hematopoiesis (Q28207579)

International Journal of Hematology

Europe PubMed Central

title

RUNX1/AML1: a central player in hematopoiesis (English)

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T Okuda

1

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M Nishimura

series ordinal

2

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M Nakao

series ordinal

3

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Y Fujita

series ordinal

4

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language of work or name

English

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publication date

October 2001

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published in

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volume

74

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issue

3

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page(s)

252-7

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cites work

AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

In vitro generation of lymphohematopoietic cells from endothelial cells purified from murine embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Patterning of cells in the Drosophila eye by Lozenge, which shares homologous domains with AML1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Definitive hematopoiesis is autonomously initiated by the AGM region

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

A new transcription factor family associated with human leukemias.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Identification of an alternatively spliced form of the mouse AML1/RUNX1 gene transcript AML1c and its expression in early hematopoietic development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

The Drosophila segmentation gene runt encodes a novel nuclear regulatory protein that is also expressed in the developing nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Requirement of Runx1/AML1/PEBP2alphaB for the generation of haematopoietic cells from endothelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

The partner gene of AML1 in t(16;21) myeloid malignancies is a novel member of the MTG8(ETO) family.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

The transcriptional control of hematopoiesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Intraaortic hemopoietic cells are derived from endothelial cells during ontogeny.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

CD34 expression patterns during early mouse development are related to modes of blood vessel formation and reveal additional sites of hematopoiesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Biallelic and heterozygous point mutations in the runt domain of the AML1/PEBP2alphaB gene associated with myeloblastic leukemias

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Cbfa2 is required for the formation of intra-aortic hematopoietic clusters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

TLE, the Human Homolog of Groucho, Interacts with AML1 and Acts as a Repressor of AML1-Induced Transactivation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Mouse embryonic hematopoiesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Biological characteristics of the leukemia-associated transcriptional factor AML1 disclosed by hematopoietic rescue of AML1-deficient embryonic stem cells by using a knock-in strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Specification of Drosophila hematopoietic lineage by conserved transcription factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Expression of runt in the mouse embryo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Potential intraembryonic hemogenic sites at pre-liver stages in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

A role for hematopoietic stem cells in promoting angiogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

The Runt domain identifies a new family of heteromeric transcriptional regulators.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020

Expression and function of a stem cell promoter for the murine CBFalpha2 gene: distinct roles and regulation in natural killer and T cell development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11721959

12 December 2020