The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells (Q28198688)

Europe PubMed Central

title

The human melanocyte: a model system to study the complexity of cellular aging and transformation in non-fibroblastic cells (English)

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D Bandyopadhyay

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N Timchenko

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T Suwa

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P J Hornsby

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J Campisi

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E E Medrano

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

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language of work or name

English

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publication date

August 2001

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published in

Experimental Gerontology

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volume

36

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issue

8

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page(s)

1265-75

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cites work

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Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

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Telomere length predicts replicative capacity of human fibroblasts

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High levels of expression of p27KIP1 and cyclin E in invasive primary malignant melanomas

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Melanin accumulation accelerates melanocyte senescence by a mechanism involving p16INK4a/CDK4/pRB and E2F1

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Tumor suppressors and oncogenes in cellular senescence.

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Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

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Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases

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Apoptosis in proliferating, senescent, and immortalized keratinocytes

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Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

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Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes

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Where the cell cycle and histones meet

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Activation of a cAMP pathway and induction of melanogenesis correlate with association of p16(INK4) and p27(KIP1) to CDKs, loss of E2F-binding activity, and premature senescence of human melanocytes.

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The regulation of normal melanocyte proliferation

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Deregulated E2F transcriptional activity in autonomously growing melanoma cells

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The serial cultivation of human diploid cell strains

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Active remodeling of somatic nuclei in egg cytoplasm by the nucleosomal ATPase ISWI

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Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein

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The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

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Terminal differentiation and senescence in the human melanocyte: repression of tyrosine-phosphorylation of the extracellular signal-regulated kinase 2 selectively defines the two phenotypes

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Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

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Cyclin-dependent regulation of G1 in mammalian fibroblasts.

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Replicative senescence as a barrier to human cancer

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Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells

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Tyrosine levels regulate the melanogenic response to alpha-melanocyte-stimulating hormone in human melanocytes: implications for pigmentation and proliferation

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Repression of c-fos transcription and an altered genetic program in senescent human fibroblasts

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Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest

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CDK inhibitors: positive and negative regulators of G1-phase progression

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Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents

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Overexpression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) in human cutaneous malignant melanoma

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