Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes (Q28189644)

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Chiara Zuccato

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Marta Valenza

Marta Valenza

5

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Luciano Conti

Luciano Conti

6

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Michael R. Hayden

Michael R Hayden

9

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Blair R Leavitt

8

Blair R Leavitt

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author name string

Marzia Tartari

2

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Andrea Crotti

3

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Donato Goffredo

4

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Tiziana Cataudella

7

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Tõnis Timmusk

10

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Dorotea Rigamonti

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

11

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language of work or name

English

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publication date

September 2003

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published in

Nature Genetics

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volume

35

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issue

1

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page(s)

76-83

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cites work

1 reference

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7 January 2021

Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease

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7 January 2021

REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons

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7 January 2021

The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes

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7 January 2021

Identification of potential target genes for the neuron-restrictive silencer factor

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Lessons from animal models of Huntington's disease

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7 January 2021

Loss of normal huntingtin function: new developments in Huntington's disease research

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7 January 2021

Multiple promoters direct tissue-specific expression of the rat BDNF gene

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7 January 2021

Identification of brain-derived neurotrophic factor promoter regions mediating tissue-specific, axotomy-, and neuronal activity-induced expression in transgenic mice

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7 January 2021

ST14A cells have properties of a medium-size spiny neuron.

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7 January 2021

Wild-type huntingtin protects from apoptosis upstream of caspase-3.

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7 January 2021

Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells

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Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

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7 January 2021

Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes

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7 January 2021

Regulation of neuronal traits by a novel transcriptional complex

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7 January 2021

Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene

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7 January 2021

Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat

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7 January 2021

Differential regulation by multiple promoters of the gene encoding the neuron-restrictive silencer factor

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7 January 2021

Studies on the interaction of REST4 with the cholinergic repressor element-1/neuron restrictive silencer element

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7 January 2021

Role of zinc finger domains of the transcription factor neuron-restrictive silencer factor/repressor element-1 silencing transcription factor in DNA binding and nuclear localization

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A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.

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7 January 2021

Mutant protein in Huntington disease is resistant to proteolysis in affected brain

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7 January 2021

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

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7 January 2021

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

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7 January 2021

Calpain activation in Huntington's disease.

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7 January 2021

Depletion of wild-type huntingtin in mouse models of neurologic diseases

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7 January 2021

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

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7 January 2021

Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons

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7 January 2021

Tissue-specific in vitro transcription from the mouse albumin promoter

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7 January 2021

Identifiers

DOI

10.1038/NG1219

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12881722

1 reference

Consolidated OpenCitations Corpus – April 2017