Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons (Q27671836)

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11 February 2020

title

Structural linkage between ligand discrimination and receptor activation by type I interferons (English)

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11 February 2020

1

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11 February 2020

11

Garry P Nolan

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11 February 2020

Ignacio Moraga

2

1 reference

ORCID Public Data File 2021

Susan E Vleck

9

object named as

Susan E Vleck

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author name string

Doron Levin

3

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11 February 2020

Peter O Krutzik

4

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11 February 2020

Yulia Podoplelova

5

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11 February 2020

Angelica Trejo

6

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11 February 2020

Choongho Lee

7

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11 February 2020

Ganit Yarden

8

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11 February 2020

Jeffrey S Glenn

10

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Jacob Piehler

12

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Gideon Schreiber

13

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K Christopher Garcia

14

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language of work or name

English

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publication date

1 August 2011

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11 February 2020

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11 February 2020

volume

146

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issue

4

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page(s)

621-632

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Crystal Structure of Human Interferon-λ1 in Complex with Its High-Affinity Receptor Interferon-λR1

11 February 2020

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Intermolecular Interactions in a 44 kDa Interferon−Receptor Complex Detected by Asymmetric Reverse-Protonation and Two-Dimensional NOESY

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The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding

20 March 2017

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Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site

20 March 2017

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Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography

20 March 2017

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20 March 2017

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20 March 2017

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Interferons at age 50: past, current and future impact on biomedicine

20 March 2017

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20 March 2017

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20 March 2017

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Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor

20 March 2017

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Stochastic receptor expression determines cell fate upon interferon treatment

20 March 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Inteferons pen the JAK-STAT pathway

29 September 2017

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An interferon alpha2 mutant optimized by phage display for IFNAR1 binding confers specifically enhanced antitumor activities

29 September 2017

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Determination of the human type I interferon receptor binding site on human interferon-alpha2 by cross saturation and an NMR-based model of the complex

29 September 2017

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Complex modulation of cell type-specific signaling in response to type I interferons

29 September 2017

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29 September 2017

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Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling

29 September 2017

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29 September 2017

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Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.

29 September 2017

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29 September 2017

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Structural analysis of IL-10 and Type I interferon family members and their complexes with receptor

29 September 2017

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Identification of residues of the IFNAR1 chain of the type I human interferon receptor critical for ligand binding and biological activity

29 September 2017

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Structure of the interferon-receptor complex determined by distance constraints from double-mutant cycles and flexible docking

29 September 2017

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New structural and functional aspects of the type I interferon-receptor interaction revealed by comprehensive mutational analysis of the binding interface

29 September 2017

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The function of type I interferons in antimicrobial immunity.

29 September 2017

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The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signaling

29 September 2017

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Differential receptor subunit affinities of type I interferons govern differential signal activation.

2 June 2018

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Antitumor effects of interferon-omega: in vivo therapy of human tumor xenografts in nude mice.

2 June 2018

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The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities.

2 June 2018

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Comparable potency of IFNalpha2 and IFNbeta on immediate JAK/STAT activation but differential down-regulation of IFNAR2.

27 November 2018

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Mutational analysis of the IFNAR1 binding site on IFNalpha2 reveals the architecture of a weak ligand-receptor binding-site.

27 November 2018

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Hydrophobic cluster analysis reveals duplication in the external structure of human alpha-interferon receptor and homology with gamma-interferon receptor external domain

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21854986

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Ligand binding induces a conformational change in ifnar1 that is propagated to its membrane-proximal domain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21854986

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2011.06.048

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

4011693

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OpenCitations bibliographic resource ID

11 February 2020

4011693

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

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11 February 2020

PubMed publication ID

21854986

1 reference