Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway (Q27667100)

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23 January 2020

title

Structural characterization of CalO1: a putative orsellinic acid methyltransferase in the calicheamicin-biosynthetic pathway (English)

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23 January 2020

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2

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23 January 2020

Jon S Thorson

series ordinal

4

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23 January 2020

5

George N Phillips

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23 January 2020

3

Craig A Bingman

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23 January 2020

author name string

Aram Chang

series ordinal

1

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23 January 2020

publication date

15 February 2011

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Acta Crystallographica Section D: Biological Crystallography

23 January 2020

published in

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23 January 2020

volume

67

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23 January 2020

issue

Pt 3

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23 January 2020

page(s)

197-203

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Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes

23 January 2020

cites work

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MolProbity: all-atom structure validation for macromolecular crystallography

20 March 2017

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Structural characterization of CalO2: A putative orsellinic acid P450 oxidase in the calicheamicin biosynthetic pathway

20 March 2017

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20 March 2017

A short history of SHELX

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Structural insight into the self-sacrifice mechanism of enediyne resistance

20 March 2017

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Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases

20 March 2017

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Solution structure of the calicheamicin gamma 1I-DNA complex

20 March 2017

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Searching protein structure databases with DaliLite v.3

20 March 2017

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Inference of macromolecular assemblies from crystalline state

20 March 2017

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Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

20 March 2017

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Protein production by auto-induction in high density shaking cultures

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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Automated protein model building combined with iterative structure refinement

20 March 2017

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Resistance to enediyne antitumor antibiotics by CalC self-sacrifice

20 March 2017

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The calicheamicin gene cluster and its iterative type I enediyne PKS

20 March 2017

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Exploiting the reversibility of natural product glycosyltransferase-catalyzed reactions

20 March 2017

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The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases

20 March 2017

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Antitumor antibiotics: bleomycin, enediynes, and mitomycin

20 March 2017

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Crystal structure of a ternary complex of DnrK, a methyltransferase in daunorubicin biosynthesis, with bound products

20 March 2017

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Comparative protein structure modeling using MODELLER

20 March 2017

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Unraveling hot spots in binding interfaces: progress and challenges

7 April 2017

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The biosynthetic genes encoding for the production of the dynemicin enediyne core in Micromonospora chersina ATCC53710

7 April 2017

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A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis

29 September 2017

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Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis

29 September 2017

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Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks

29 September 2017

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Carrier protein structure and recognition in polyketide and nonribosomal peptide biosynthesis.

29 September 2017

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Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase.

29 September 2017

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Arming antibodies: prospects and challenges for immunoconjugates

29 September 2017

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Tumour-targeted chemotherapy with immunoconjugates of calicheamicin

29 September 2017

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Neocarzinostatin naphthoate synthase: an unique iterative type I PKS from neocarzinostatin producer Streptomyces carzinostaticus.

29 September 2017

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Enediyne Natural Products: Biosynthesis and Prospect Towards Engineering Novel Antitumor Agents

29 September 2017

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Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model

29 September 2017

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Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms

29 September 2017

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Designed enediyne antitumor agents

29 September 2017

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Understanding and exploiting nature's chemical arsenal: the past, present and future of calicheamicin research.

29 September 2017

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Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tü57.

29 September 2017

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Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis.

29 September 2017

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A genomics-guided approach for discovering and expressing cryptic metabolic pathways.

2 June 2018

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Biosynthesis of the enediyne antitumor antibiotic C-1027

27 November 2018

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12 December 2020

Phase combination and cross validation in iterated density-modification calculations

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12 December 2020

Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificity

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12 December 2020

Processing of X-ray diffraction data collected in oscillation mode

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12 December 2020

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

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12 December 2020

Calicheamicin gamma 1I: an antitumor antibiotic that cleaves double-stranded DNA site specifically

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12 December 2020

10.1107/S090744491100360X

Identifiers

DOI

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23 January 2020

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23 January 2020

PubMed publication ID

21358050

1 reference